دورية أكاديمية
أعرض في EDS

Recent advances in the understanding and management of polycystic ovary syndrome.

التفاصيل البيبلوغرافية
العنوان: Recent advances in the understanding and management of polycystic ovary syndrome.
المؤلفون: Rocha AL; Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Oliveira FR; Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Azevedo RC; Department of Internal Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Silva VA; Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Peres TM; Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Candido AL; Department of Internal Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Gomes KB; Department of Clinical and Toxicological Analysis, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Reis FM; Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
المصدر: F1000Research [F1000Res] 2019 Apr 26; Vol. 8. Date of Electronic Publication: 2019 Apr 26 (Print Publication: 2019).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: F1000 Research Ltd Country of Publication: England NLM ID: 101594320 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-1402 (Electronic) Linking ISSN: 20461402 NLM ISO Abbreviation: F1000Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : F1000 Research Ltd
مواضيع طبية MeSH: Insulin Resistance*, Obesity/*complications , Polycystic Ovary Syndrome/*therapy, Aromatase Inhibitors/therapeutic use ; Clomiphene/therapeutic use ; Female ; Humans ; Letrozole/therapeutic use ; Polycystic Ovary Syndrome/complications
مستخلص: Polycystic ovary syndrome (PCOS) is a multifaceted condition characterized by chronic anovulation and excess ovarian activity, in contrast to other causes of anovulation that involve ovarian dormancy or primary insufficiency. Recent studies indicated that PCOS is associated with low-grade chronic inflammation and that women with PCOS are at increased risk of non-alcoholic fatty liver disease. The inflammatory and metabolic derangements associated with PCOS are explained in part by the coexistence of insulin resistance and obesity but are further fueled by the androgen excess. New insights into the regulation of hormones and cytokines in muscle and fat tissue support the concept that PCOS is a systemic syndrome. The therapeutic plan should be tailored to the patient phenotype, complaints, and reproductive desire. Of note, the aromatase inhibitor letrozole seems to be more effective than the reference drug clomiphene citrate to treat infertility due to PCOS. Integral management by a multidisciplinary team may help the patients to adhere to lifestyle interventions and thereby reduce body adiposity and recover their metabolic and reproductive health.
Competing Interests: No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.
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فهرسة مساهمة: Keywords: PCOS; infertility; insulin resistance; menstrual irregularity; polycystic ovary syndrome
المشرفين على المادة: 0 (Aromatase Inhibitors)
1HRS458QU2 (Clomiphene)
7LKK855W8I (Letrozole)
تواريخ الأحداث: Date Created: 20190510 Date Completed: 20200604 Latest Revision: 20200604
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6489978
DOI: 10.12688/f1000research.15318.1
PMID: 31069057
قاعدة البيانات: MEDLINE
الوصف
تدمد:2046-1402
DOI:10.12688/f1000research.15318.1