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Comparative effect of indomethacin (IndoM) on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in the kidney, small intestine and liver of rats.

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العنوان: Comparative effect of indomethacin (IndoM) on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in the kidney, small intestine and liver of rats.
المؤلفون: Khan S; Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, India., Yusufi FNK; Department of Statistics and Operations Research, Faculty of Science, Aligarh Muslim University, Aligarh, 202002, U.P., India., Yusufi ANK; Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, India.
المصدر: Toxicology reports [Toxicol Rep] 2019 May 04; Vol. 6, pp. 389-394. Date of Electronic Publication: 2019 May 04 (Print Publication: 2019).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ireland Ltd Country of Publication: Ireland NLM ID: 101630272 Publication Model: eCollection Cited Medium: Internet ISSN: 2214-7500 (Electronic) Linking ISSN: 22147500 NLM ISO Abbreviation: Toxicol Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Ireland] : Elsevier Ireland Ltd., [2014]-
مستخلص: Indomethacin (IndoM) has prominent anti-inflammatory and analgesic-antipyretic properties. However, high incidence and severity of side-effects on the structure and functions of the kidney, liver and intestine limits its clinical use. The present study tested the hypothesis that IndoM causes multi-organ toxicity by inducing oxidative stress that alters the structure of various cellular membranes, metabolism and hence functions. The effect of IndoM was determined on the enzymes of carbohydrate metabolism, brush border membrane (BBM) and oxidative stress in the rat kideny, liver and intestine to understand the mechanism of IndoM induced toxicity. Adult male Wister rats were given IndoM (20 mg/kg) intra-peritoneally in sodium bicarbonate twice a day for 3 d. The body weights of the rats were recorded before and after experimental procedure. IndoM administration significantly increased blood urea nitrogen, serum creatinine, cholesterol and alkaline phosphatase but inorganic phosphate indicating IndoM induced renal, hepatic and intestinal toxicity. Activity of lactate dehydrogenase along with glucose-6- and fructose-1, 6-bis phosphatase, glucose-6-phosphate dehydrogenase and NADP-malic enzyme increased but malate dehydrogenase decreased in all tissues. Lipid peroxidation (LPO) significantly increased whereas the antioxidant enzymes decreased in all rat tissues studied. The results indicate that IndoM administration caused severe damage to kidney, liver and intestine by icreasing LPO, suppressing antioxidant enzymes and inhibiting oxidative metablolism. The energy dependence was shifted to anaerobic glycolysis due to mitochondrial damage supported by increased gluconeogenesis to provide more glucose to meet energy requirements.
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فهرسة مساهمة: Keywords: ACPase, Acid phosphatase an enzyme; ALP, Alkaline phosphatase an enzyme; ANOVA, Analysis of variance statistical tool; ATP, Adenosine 5’-triphosphate energy currency; BBM, Brush border membrane intestinal membrane; BBMV, Brush border membrane vesicles; BUN, Blood urea nitrogen blood parameter; Carbohydrate metabolism; G6PDH, Glucose-6-phosphate dehydrogenase an enzyme; G6Pase, Glucose-6-phosphatase an enzyme; GGTase, γ-Glutammyl transferase an enzyme; HK, Hexokinase an enzyme; HMP, Hexose monophosphate; Indomethacin; Intestine; Kidney; LAP, Leucine amino peptidase, an enzyme; LDH, Lactate dehydrogenase an enzyme; LPO, Lipid peroxidation; Liver; MDH, Malate dehydrogenase an enzyme; ME, Malic enzyme an enzyme; NADP+, Nicotinamide adenine dinucleotide phosphate; NADPH, Nicotinamide adenine dinucleotide phosphate (reduced) reducing equivalent; Oxidative stress; Pi, Inorganic phosphate; ROS, Reactive oxygen species; SH, Sulfhydryl groups; SOD, Superoxide dismutase, an enzyme; TCA cycle, Tri-carboxylic acid cycle; Toxicity
تواريخ الأحداث: Date Created: 20190514 Latest Revision: 20240720
رمز التحديث: 20240720
مُعرف محوري في PubMed: PMC6506459
DOI: 10.1016/j.toxrep.2019.04.010
PMID: 31080746
قاعدة البيانات: MEDLINE
الوصف
تدمد:2214-7500
DOI:10.1016/j.toxrep.2019.04.010