دورية أكاديمية
Evaluation of anticonvulsant and antiepileptogenic activity of Euphorbia nivulia in PTZ-induced kindling model of epilepsy in mice.
| العنوان: | Evaluation of anticonvulsant and antiepileptogenic activity of Euphorbia nivulia in PTZ-induced kindling model of epilepsy in mice. |
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| المؤلفون: | Rehman AH; Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan., Al Sharari SD; Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan / Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia / Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, US., Ahmad M; Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan., Akhtar M; Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan., Khan Y; Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan., Ashraf MN; Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan. |
| المصدر: | Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2019 Mar; Vol. 32 (2), pp. 675-681. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Faculty of Pharmacy, University of Karachi Country of Publication: Pakistan NLM ID: 9426356 Publication Model: Print Cited Medium: Internet ISSN: 1011-601X (Print) Linking ISSN: 1011601X NLM ISO Abbreviation: Pak J Pharm Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Karachi : Faculty of Pharmacy, University of Karachi, [1988- |
| مواضيع طبية MeSH: | Anticonvulsants/*pharmacology , Epilepsy/*drug therapy , Euphorbia/*chemistry , Plant Extracts/*pharmacology, Animals ; Anticonvulsants/chemistry ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Epilepsy/chemically induced ; Fumaria/chemistry ; Kindling, Neurologic/drug effects ; Male ; Mice ; Pentylenetetrazole/toxicity ; Plant Extracts/chemistry ; Plants, Medicinal/chemistry ; Seizures/chemically induced ; Seizures/drug therapy ; Spectroscopy, Fourier Transform Infrared |
| مستخلص: | Epilepsy remains a major chronic neurological disorder with significantly higher refractory seizure rate. Based on the folk medicine literature, we explored the anticonvulsant and antiepileptogenic activity of aqueous ethanolic extracts of Fumaria indica, Euphorbia lactea, Euphorbia helioscopia, Neurada procumbens, and Euphorbia nivulia. The acute anticonvulsant activity of the extracts was determined at different concentrations in different groups of Swiss albino mice. Among all the materials tested, the ethanolic extracts of Euphorbia nivulia (eth-EN) alone was found to exhibit concentration-dependent anticonvulsant effects when evaluated against the acute convulsant dose of Pentylenetetrazole (PTZ, 90mg/kg, s.c.). eth-EN extract at 100mg/kg i.p concentration showed maximum protection against the PTZ induced mortality (P<0.05). eth-EN (100mg/kg) treated animals also showed significant reduction in the progression of epileptogenesis (P<0.05) when tested against the PTZ-induced (50mg/kg s.c.) chemical kindling model of epilepsy. The FT-IR spectra of this extract showed both known and unknown spectral peaks from which the presence of the functional groups; i.e. aromatics, diketones, alkenes, carbonyls, carboxylic acids and amide compounds were confirmed. The unknown peaks strongly suggested the presence of novel compounds that may be responsible for its anticonvulsant and antiepileptogenic activity. |
| المشرفين على المادة: | 0 (Anticonvulsants) 0 (Plant Extracts) WM5Z385K7T (Pentylenetetrazole) |
| تواريخ الأحداث: | Date Created: 20190514 Date Completed: 20200102 Latest Revision: 20200102 |
| رمز التحديث: | 20240628 |
| PMID: | 31081782 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1011-601X |
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