دورية أكاديمية
Atrazine induced transgenerational reproductive effects in medaka (Oryzias latipes).
| العنوان: | Atrazine induced transgenerational reproductive effects in medaka (Oryzias latipes). |
|---|---|
| المؤلفون: | Cleary JA; Department of Biology, University of North Carolina Greensboro, Greensboro, NC 27412, USA., Tillitt DE; U.S. Geological Survey, Columbia Environmental Research Center, Columbia, MO 65201, USA., Vom Saal FS; Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA., Nicks DK; U.S. Geological Survey, Columbia Environmental Research Center, Columbia, MO 65201, USA., Claunch RA; U.S. Geological Survey, Columbia Environmental Research Center, Columbia, MO 65201, USA., Bhandari RK; Department of Biology, University of North Carolina Greensboro, Greensboro, NC 27412, USA. Electronic address: rkbhanda@uncg.edu. |
| المصدر: | Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2019 Aug; Vol. 251, pp. 639-650. Date of Electronic Publication: 2019 May 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8804476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6424 (Electronic) Linking ISSN: 02697491 NLM ISO Abbreviation: Environ Pollut |
| أسماء مطبوعة: | Original Publication: Barking, Essex, England : Elsevier Applied Science Publishers, c1987- |
| مواضيع طبية MeSH: | Atrazine/*toxicity , Herbicides/*toxicity , Oryzias/*physiology , Reproduction/*drug effects , Water Pollutants, Chemical/*toxicity, Animals ; Dose-Response Relationship, Drug ; Endocrine System/drug effects ; Endocrine System/growth & development ; Ethinyl Estradiol/pharmacology ; Female ; Male |
| مستخلص: | Atrazine is presently one of the most abundantly used herbicides in the United States, and a common contaminant of natural water bodies and drinking waters in high-use areas. Dysregulation of reproductive processes has been demonstrated in atrazine exposed fish, including alteration of key endocrine pathways on hypothalamic-pituitary-gonadal (HPG) axis. However, the potential for atrazine-induced transgenerational inheritance of reproductive effects in fish has not been investigated. The present study examined the effects of early developmental atrazine exposure on transgenerational reproductive dysregulation in Japanese medaka (Oryzias latipes). F0 medaka were exposed to atrazine (ATZ, 5 or 50 μg/L), 17α-ethinylestradiol (EE2, 0.002 or 0.05 μg/L), or solvent control during the first twelve days of development with no subsequent exposure over three generations. This exposure overlapped with the critical developmental window for embryonic germ cell development, gonadogenesis, and sex determination. Exposed males and females of the F0 generation were bred to produce an F1 generation, and this was continued until the F2 generation. Sperm count and motility were not affected in F0 males; however, both parameters were significantly reduced in the males from F2 Low EE2 (0.002 μg/L), Low ATZ (5 μg/L), and High ATZ (50 μg/L) lineages. Fecundity was unaffected by atrazine or EE2 in F0 through F2 generations; however, fertilization rate was decreased in low atrazine and EE2 exposure lineages in the F2 generation. There were significant transgenerational differences in expression of the genes involved in steroidogenesis and DNA methylation. These results suggest that although early life exposure to atrazine did not cause significant phenotypes in the directly exposed F0 generation, subsequent generations of fish were at greater risk of reproductive dysfunction. (Copyright © 2019 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Atrazine; Epigenetics; Medaka fish; Reproduction; Transgenerational inheritance |
| المشرفين على المادة: | 0 (Herbicides) 0 (Water Pollutants, Chemical) 423D2T571U (Ethinyl Estradiol) QJA9M5H4IM (Atrazine) |
| تواريخ الأحداث: | Date Created: 20190521 Date Completed: 20190826 Latest Revision: 20190826 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.envpol.2019.05.013 |
| PMID: | 31108297 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!