دورية أكاديمية
Regulation of Cdc42 and its effectors in epithelial morphogenesis.
| العنوان: | Regulation of Cdc42 and its effectors in epithelial morphogenesis. |
|---|---|
| المؤلفون: | Pichaud F; MRC - Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK f.pichaud@ucl.ac.uk.; Institute for the Physics of Living Systems, University College London, London WC1E 6BT, UK., Walther RF; MRC - Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK., Nunes de Almeida F; MRC - Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK. |
| المصدر: | Journal of cell science [J Cell Sci] 2019 May 21; Vol. 132 (10). Date of Electronic Publication: 2019 May 21. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-9137 (Electronic) Linking ISSN: 00219533 NLM ISO Abbreviation: J Cell Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge : Company of Biologists Original Publication: London. |
| مواضيع طبية MeSH: | Epithelial Cells/*metabolism , cdc42 GTP-Binding Protein/*metabolism, Animals ; Epithelial Cells/cytology ; Humans ; Morphogenesis |
| مستخلص: | Cdc42 - a member of the small Rho GTPase family - regulates cell polarity across organisms from yeast to humans. It is an essential regulator of polarized morphogenesis in epithelial cells, through coordination of apical membrane morphogenesis, lumen formation and junction maturation. In parallel, work in yeast and Caenorhabditis elegans has provided important clues as to how this molecular switch can generate and regulate polarity through localized activation or inhibition, and cytoskeleton regulation. Recent studies have revealed how important and complex these regulations can be during epithelial morphogenesis. This complexity is mirrored by the fact that Cdc42 can exert its function through many effector proteins. In epithelial cells, these include atypical PKC (aPKC, also known as PKC-3), the P21-activated kinase (PAK) family, myotonic dystrophy-related Cdc42 binding kinase beta (MRCKβ, also known as CDC42BPB) and neural Wiskott-Aldrich syndrome protein (N-WASp, also known as WASL). Here, we review how the spatial regulation of Cdc42 promotes polarity and polarized morphogenesis of the plasma membrane, with a focus on the epithelial cell type. Competing Interests: Competing interestsThe authors declare no competing or financial interests. (© 2019. Published by The Company of Biologists Ltd.) |
| معلومات مُعتمدة: | MC_UU_00012/3 United Kingdom MRC_ Medical Research Council; MC UU 00012/3 United Kingdom MRC_ Medical Research Council; MC UU 12018/3 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: Cdc42; Epithelia; MRCK; PAK; Par complex; Polarity |
| المشرفين على المادة: | EC 3.6.5.2 (cdc42 GTP-Binding Protein) |
| تواريخ الأحداث: | Date Created: 20190523 Date Completed: 20200723 Latest Revision: 20210109 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1242/jcs.217869 |
| PMID: | 31113848 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1477-9137 |
|---|---|
| DOI: | 10.1242/jcs.217869 |