دورية أكاديمية
أعرض في EDS

Immunopathogenesis of Pediatric Localized Scleroderma.

التفاصيل البيبلوغرافية
العنوان: Immunopathogenesis of Pediatric Localized Scleroderma.
المؤلفون: Torok KS; Division of Pediatric Rheumatology, Department of Pediatrics, Childrens's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, United States., Li SC; Division of Pediatric Rheumatology, Department of Pediatrics, Hackensack University Medical Center, Hackensack, NJ, United States.; Hackensack Meridian School of Medicine at Seton Hall University, Clifton, NJ, United States., Jacobe HM; Department of Dermatology, UT Southwestern Medical Center, Dallas, TX, United States., Taber SF; Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, NY, United States.; Department of Pediatrics, Weill Cornell Medicine, New York, NY, United States., Stevens AM; Division of Pediatric Rheumatology, Department of Pediatrics, University of Washington, Seattle, WA, United States.; Seattle Children's Research Institute, University of Washington, Seattle, WA, United States., Zulian F; Pediatric Rheumatology Unit, Department of Woman's and Child's Health, University of Padua, Padua, Italy., Lu TT; Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, NY, United States.; HSS Research Institute, Hospital for Special Surgery, New York, NY, United States.; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, United States.
المصدر: Frontiers in immunology [Front Immunol] 2019 Apr 30; Vol. 10, pp. 908. Date of Electronic Publication: 2019 Apr 30 (Print Publication: 2019).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: Autoantibodies*/genetics , Autoantibodies*/immunology , HLA Antigens*/genetics , HLA Antigens*/immunology , Macrophages*/immunology , Macrophages*/pathology , Scleroderma, Localized*/genetics , Scleroderma, Localized*/immunology , Scleroderma, Localized*/pathology , Skin*/immunology , Skin*/pathology , T-Lymphocytes, Helper-Inducer*/immunology , T-Lymphocytes, Helper-Inducer*/pathology, Child ; Child, Preschool ; Female ; Humans ; Male ; RNA-Seq
مستخلص: Localized scleroderma (LS) is a complex disease characterized by a mixture of inflammation and fibrosis of the skin that, especially in the pediatric population, also affects extracutaneous tissues ranging from muscle to the central nervous system. Although developmental origins have been hypothesized, evidence points to LS as a systemic autoimmune disorder, as there is a strong correlation to family history of autoimmune disease, the presence of shared HLA types with rheumatoid arthritis, high frequency of auto-antibodies, and elevated circulating chemokines and cytokines associated with T-helper cell, IFNγ, and other inflammatory pathways. This inflammatory phenotype of the peripheral blood is reflected in the skin via microarray, RNA Sequencing and tissue staining. Research is underway to identify the key players in the pathogenesis of LS, but close approximation of inflammatory lymphocytic and macrophage infiltrate with collagen and fibroblasts deposition supports the notion that LS is a disease of inflammatory driven fibrosis. The immune system is dynamic and undergoes changes during childhood, and we speculate on how the unique features of the immune system in childhood could potentially contribute to some of the differences in LS between children and adults. Interestingly, the immune phenotype in pediatric LS resembles to some extent the healthy adult cellular phenotype, possibly supporting accelerated maturation of the immune system in LS. We discuss future directions in better understanding the pathophysiology of and how to better treat pediatric LS.
References: Front Immunol. 2017 Aug 11;8:957. (PMID: 28848557)
Proc Biol Sci. 2015 Dec 22;282(1821):20143085. (PMID: 26702035)
J Rheumatol. 2008 Apr;35(4):650-7. (PMID: 18322985)
Br J Dermatol. 2014 Apr;170(4):895-900. (PMID: 24341905)
JAMA Dermatol. 2013 Oct;149(10):1159-65. (PMID: 23925398)
Arch Dermatol. 1994 Oct;130(10):1327-8. (PMID: 7944520)
Arthritis Rheum. 1996 Jun;39(6):1041-9. (PMID: 8651969)
Postepy Dermatol Alergol. 2016 Feb;33(1):47-51. (PMID: 26985179)
Immunity. 2017 Mar 21;46(3):350-363. (PMID: 28329702)
Int J Dermatol. 2006 Nov;45(11):1296-9. (PMID: 17076709)
J Rheumatol. 2018 Dec;45(12):1680-1688. (PMID: 30219769)
Plast Reconstr Surg. 1990 May;85(5):669-74; discussion 675-6. (PMID: 2326349)
J Invest Dermatol. 2013 Mar;133(3):827-830. (PMID: 23096712)
J Invest Dermatol. 2018 May;138(5):1212-1215. (PMID: 29246801)
J Invest Dermatol. 2017 May;137(5):1042-1050. (PMID: 28012718)
Arthritis Rheum. 2005 Sep;52(9):2873-81. (PMID: 16142730)
Pediatr Clin North Am. 2018 Aug;65(4):757-781. (PMID: 30031497)
Arch Dermatol. 2009 Nov;145(11):1303-8. (PMID: 19917961)
J Neurol. 1990 Oct;237(6):379-81. (PMID: 2277274)
Br J Dermatol. 2006 Nov;155(5):1013-20. (PMID: 17034534)
Arthritis Rheum. 2011 Jul;63(7):1998-2006. (PMID: 21305525)
J Rheumatol. 1997 Jan;24(1):73-80. (PMID: 9002014)
Neurology. 1997 Apr;48(4):1013-8. (PMID: 9109892)
Arthritis Rheum. 2003 Aug;48(8):2246-55. (PMID: 12905479)
Arthritis Rheumatol. 2014 Nov;66(11):3170-7. (PMID: 25223600)
J Rheumatol. 2008 Dec;35(12):2439-44. (PMID: 19004036)
J Dermatol. 2011 Aug;38(8):778-83. (PMID: 21366680)
J Am Acad Dermatol. 2017 Jun;76(6):1124-1130. (PMID: 28285783)
J Am Acad Dermatol. 2012 Dec;67(6):1157-62. (PMID: 22533994)
Rheumatology (Oxford). 2005 Mar;44(3):274-9. (PMID: 15561734)
Eur J Pediatr. 2015 Sep;174(9):1247-54. (PMID: 25851111)
Clin Immunol. 2013 Oct;149(1):146-55. (PMID: 23994768)
Arthritis Rheum. 1994 Mar;37(3):391-4. (PMID: 8129794)
Eur J Dermatol. 2003 Mar-Apr;13(2):171-6. (PMID: 12695134)
J Invest Dermatol. 2013 Aug;133(8):1979-89. (PMID: 23677167)
Arthritis Care Res (Hoboken). 2017 Jul;69(7):1082-1087. (PMID: 27696700)
Br J Dermatol. 2013 Dec;169(6):1265-71. (PMID: 24032480)
Scand J Immunol. 2016 Apr;83(4):255-66. (PMID: 26808160)
J Rheumatol. 2000 Aug;27(8):1917-21. (PMID: 10955333)
Semin Immunol. 1999 Apr;11(2):73-83. (PMID: 10329494)
J Pediatr. 2005 Mar;146(3):429-31. (PMID: 15756237)
Neuroradiology. 2015 Jan;57(1):21-34. (PMID: 25304124)
J Invest Dermatol. 2019 Mar;139(3):715-718. (PMID: 30616925)
Clin Rheumatol. 2010 Sep;29(9):1055-9. (PMID: 20549277)
Arthritis Rheum. 2009 Mar;60(3):661-8. (PMID: 19248111)
Ann Neurol. 1995 May;37(5):679-81. (PMID: 7755364)
Curr Opin Rheumatol. 2006 Nov;18(6):606-13. (PMID: 17053506)
Neuropediatrics. 1995 Dec;26(6):306-9. (PMID: 8719745)
J Rheumatol. 2006 May;33(5):1004-13. (PMID: 16583463)
Arthritis Res Ther. 2013;15(6):R188. (PMID: 24499523)
ACR Open Rheumatol. 2019 Apr 10;1(2):119-124. (PMID: 31777788)
Br J Dermatol. 2011 Dec;165(6):1308-13. (PMID: 21895625)
Clin Exp Rheumatol. 2009 May-Jun;27(3 Suppl 54):64-7. (PMID: 19796565)
Cell. 2018 Aug 23;174(5):1277-1292.e14. (PMID: 30142345)
Autoimmun Rev. 2018 Jul;17(7):727-734. (PMID: 29729451)
Semin Arthritis Rheum. 2015 Dec;45(3):284-93. (PMID: 26254121)
Regul Pept. 2011 Oct 10;170(1-3):4-6. (PMID: 21616095)
Dermatology. 2003;207(2):141-7. (PMID: 12920362)
J Lab Clin Med. 1981 Feb;97(2):264-77. (PMID: 6450255)
Clin Exp Immunol. 1982 May;48(2):443-8. (PMID: 6213329)
PLoS One. 2008 Jul 16;3(7):e2696. (PMID: 18648520)
Arthritis Rheum. 1994 Jun;37(6):898-901. (PMID: 8003062)
J Immunol. 1993 Mar 1;150(5):2033-45. (PMID: 8436833)
Arch Med Sci. 2012 Dec 20;8(6):1089-95. (PMID: 23319986)
Neuroradiology. 1997 Dec;39(12):873-6. (PMID: 9457714)
Pediatr Rheumatol Online J. 2007 Dec 03;5:22. (PMID: 18053185)
Dermatol Ther. 2012 Mar-Apr;25(2):135-47. (PMID: 22741933)
Pediatr Dermatol. 2018 Jan;35(1):43-46. (PMID: 29119592)
Ann Intern Med. 1986 Jun;104(6):849-57. (PMID: 3486617)
J Rheumatol. 2012 Feb;39(2):286-94. (PMID: 22247357)
Rheumatology (Oxford). 2006 May;45(5):614-20. (PMID: 16368732)
Br J Dermatol. 2008 Jul;159(1):175-81. (PMID: 18503590)
J Am Acad Dermatol. 2008 Sep;59(3):385-96. (PMID: 18571769)
J Am Acad Dermatol. 2007 Feb;56(2):257-63. (PMID: 17147965)
Clin Chem. 2015 Aug;61(8):1075-86. (PMID: 26044509)
Arch Dermatol. 2010 Sep;146(9):1044-5. (PMID: 20855712)
J Craniomaxillofac Surg. 2003 Oct;31(5):321-4. (PMID: 14563334)
J Neurol Neurosurg Psychiatry. 2001 Mar;70(3):382-5. (PMID: 11181863)
Br J Dermatol. 2019 May;180(5):1183-1189. (PMID: 30315656)
Trends Mol Med. 2007 Mar;13(3):94-102. (PMID: 17267287)
Clin Dermatol. 2011 Mar-Apr;29(2):205-25. (PMID: 21396561)
Neurology. 2008 Nov 4;71(19):1538-45. (PMID: 18981376)
Arthritis Rheumatol. 2014 Dec;66(12):3496-504. (PMID: 25156342)
J Rheumatol. 2003 Sep;30(9):1997-2004. (PMID: 12966605)
J Am Acad Dermatol. 2012 Dec;67(6):1151-6. (PMID: 22657157)
Arch Dermatol. 2009 May;145(5):545-50. (PMID: 19451498)
J Invest Dermatol. 2017 Aug;137(8):1663-1670. (PMID: 28450066)
Arch Dermatol Res. 1995;287(2):193-7. (PMID: 7763091)
Pediatrics. 2006 Jan;117(1):e132-6. (PMID: 16326691)
معلومات مُعتمدة: R01 AI079178 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: autoimmune disease; disease etiology; fibrosis; immunophenotype; localized scleroderma; morphea; pediatric rheumatology; skin
المشرفين على المادة: 0 (Autoantibodies)
0 (HLA Antigens)
تواريخ الأحداث: Date Created: 20190523 Date Completed: 20200929 Latest Revision: 20231011
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6503092
DOI: 10.3389/fimmu.2019.00908
PMID: 31114575
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-3224
DOI:10.3389/fimmu.2019.00908