دورية أكاديمية
أعرض في EDS

Dendritic Cell-Derived TSLP Negatively Regulates HIF-1α and IL-1β During Dectin-1 Signaling.

التفاصيل البيبلوغرافية
العنوان: Dendritic Cell-Derived TSLP Negatively Regulates HIF-1α and IL-1β During Dectin-1 Signaling.
المؤلفون: Elder MJ; Department of Medicine, School of Clinical Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, United Kingdom.; Early Oncology R&D Division, AstraZeneca, Cambridge, United Kingdom., Webster SJ; Department of Medicine, School of Clinical Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, United Kingdom.; Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom., Fitzmaurice TJ; Department of Medicine, School of Clinical Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, United Kingdom., Shaunak ASD; Department of Medicine, School of Clinical Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, United Kingdom., Steinmetz M; Unit 970, INSERM, Paris Cardiovascular Research Center, Paris, France., Chee R; Department of Immunology, Royal Free Hospital, London, United Kingdom., Mallat Z; Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Cohen ES; Biopharmaceutical Research Division, AstraZeneca, Cambridge, United Kingdom., Williams DL; Department of Surgery, Center for Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States., Gaston JSH; Department of Medicine, School of Clinical Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, United Kingdom., Goodall JC; Department of Medicine, School of Clinical Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, United Kingdom.
المصدر: Frontiers in immunology [Front Immunol] 2019 May 08; Vol. 10, pp. 921. Date of Electronic Publication: 2019 May 08 (Print Publication: 2019).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: Cytokines/*immunology , Dendritic Cells/*immunology , Hypoxia-Inducible Factor 1, alpha Subunit/*immunology , Interleukin-1beta/*immunology , Lectins, C-Type/*immunology , Signal Transduction/*immunology, Dendritic Cells/cytology ; Humans
مستخلص: Thymic stromal lymphopoietin (TSLP) is a functionally pleotropic cytokine important in immune regulation, and TSLP dysregulation is associated with numerous diseases. TSLP is produced by many cell types, but has predominantly been characterized as a secreted factor from epithelial cells which activates dendritic cells (DC) that subsequently prime T helper (T H ) 2 immunity. However, DC themselves make significant amounts of TSLP in response to microbial products, but the functional role of DC-derived TSLP remains unclear. We show that TSLPR signaling negatively regulates IL-1β production during dectin-1 stimulation of human DC. This regulatory mechanism functions by dampening Syk phosphorylation and is mediated via NADPH oxidase-derived ROS, HIF-1α and pro-IL-1β expression. Considering the profound effect TSLPR signaling has on the metabolic status and the secretome of dectin-1 stimulated DC, these data suggest that autocrine TSLPR signaling could have a fundamental role in modulating immunological effector responses at sites removed from epithelial cell production of TSLP.
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معلومات مُعتمدة: G1001765 United Kingdom MRC_ Medical Research Council; RG/15/11/31593 United Kingdom BHF_ British Heart Foundation; 19639 United Kingdom VAC_ Versus Arthritis; MR/M020134/1 United Kingdom MRC_ Medical Research Council; R01 GM053522 United States GM NIGMS NIH HHS; R01 GM119197 United States GM NIGMS NIH HHS; R01 GM083016 United States GM NIGMS NIH HHS; C06 RR030655 United States RR NCRR NIH HHS
فهرسة مساهمة: Keywords: HIF-1α; IL-1β; ROS; Syk; TSLP; dectin-1; hypoxia
المشرفين على المادة: 0 (CLEC7A protein, human)
0 (Cytokines)
0 (HIF1A protein, human)
0 (Hypoxia-Inducible Factor 1, alpha Subunit)
0 (IL1B protein, human)
0 (Interleukin-1beta)
0 (Lectins, C-Type)
0 (TSLP protein, human)
تواريخ الأحداث: Date Created: 20190530 Date Completed: 20200924 Latest Revision: 20230201
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6519317
DOI: 10.3389/fimmu.2019.00921
PMID: 31139177
قاعدة البيانات: MEDLINE
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