دورية أكاديمية
In Situ Vaccination of Tumors Using Plant Viral Nanoparticles.
| العنوان: | In Situ Vaccination of Tumors Using Plant Viral Nanoparticles. |
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| المؤلفون: | Murray AA; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Sheen MR; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth Lebanon, Norris Cotton Cancer Center, Lebanon, NH, USA.; Department of Genetics, Geisel School of Medicine at Dartmouth Lebanon, Norris Cotton Cancer Center, Lebanon, NH, USA.; Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Veliz FA; Department of Biomedical Engineering, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Fiering SN; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth Lebanon, Norris Cotton Cancer Center, Lebanon, NH, USA.; Department of Genetics, Geisel School of Medicine at Dartmouth Lebanon, Norris Cotton Cancer Center, Lebanon, NH, USA., Steinmetz NF; Department of Biomedical Engineering, Case Western Reserve University School of Medicine, Cleveland, OH, USA. nfs11@case.edu.; Department of NanoEngineering, University of California-San Diego, La Jolla, CA, USA. nfs11@case.edu.; Department of Materials Science and Engineering, Case Western Reserve University School of Engineering, Cleveland, OH, USA. nfs11@case.edu.; Department of Macromolecular Science and Engineering, Case Western Reserve University School of Engineering, Cleveland, OH, USA. nfs11@case.edu.; Division of General Medical Sciences-Oncology, Case Western Reserve University, Cleveland, OH, USA. nfs11@case.edu. |
| المصدر: | Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2019; Vol. 2000, pp. 111-124. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Totowa, NJ : Humana Press Original Publication: Clifton, N.J. : Humana Press, |
| مواضيع طبية MeSH: | Cancer Vaccines* , Comovirus* , Nanoparticles*, Immunotherapy/*methods, Animals ; Melanoma/immunology ; Melanoma/therapy ; Mice |
| مستخلص: | Viral nanoparticles are self-assembling units that are being developed and applied for a variety of applications. While most clinical uses involve animal viruses, a plant-derived virus, cowpea mosaic virus (CPMV) has been shown to have antitumor properties in mice when applied as in situ vaccine. Here we describe the production and characterization of CPMV and its use as in situ vaccines in the context of cancer. Subsequent analyses to obtain efficacy or mechanistic data are also detailed. |
| References: | Nat Nanotechnol. 2016 Mar;11(3):295-303. (PMID: 26689376) |
| معلومات مُعتمدة: | T32 GM007250 United States GM NIGMS NIH HHS; TL1 TR000441 United States TR NCATS NIH HHS; TL1 TR002549 United States TR NCATS NIH HHS; U01 CA218292 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: B16F10; Cowpea mosaic virus (CPMV); Cytokine; Flow cytometry; Immunotherapy; In situ vaccine; Luminex multiplex; Melanoma |
| المشرفين على المادة: | 0 (Cancer Vaccines) |
| تواريخ الأحداث: | Date Created: 20190601 Date Completed: 20200312 Latest Revision: 20240928 |
| رمز التحديث: | 20240928 |
| مُعرف محوري في PubMed: | PMC7302950 |
| DOI: | 10.1007/978-1-4939-9516-5_10 |
| PMID: | 31148013 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1940-6029 |
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| DOI: | 10.1007/978-1-4939-9516-5_10 |