دورية أكاديمية
Oral delivery of indinavir using mPEG-PCL nanoparticles: preparation, optimization, cellular uptake, transport and pharmacokinetic evaluation.
| العنوان: | Oral delivery of indinavir using mPEG-PCL nanoparticles: preparation, optimization, cellular uptake, transport and pharmacokinetic evaluation. |
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| المؤلفون: | Kurd M; a Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences , Zanjan , Iran., Sadegh Malvajerd S; b Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences , Tehran , Iran., Rezaee S; c Department of Pharmaceutics, School of Pharmacy, Zanjan University of Medical Sciences , Zanjan , Iran., Hamidi M; a Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences , Zanjan , Iran.; c Department of Pharmaceutics, School of Pharmacy, Zanjan University of Medical Sciences , Zanjan , Iran., Derakhshandeh K; d Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences , Hamadan , Iran. |
| المصدر: | Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2019 Dec; Vol. 47 (1), pp. 2123-2133. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 101594777 Publication Model: Print Cited Medium: Internet ISSN: 2169-141X (Electronic) Linking ISSN: 21691401 NLM ISO Abbreviation: Artif Cells Nanomed Biotechnol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Abingdon, Oxford : Taylor & Francis Original Publication: London : Informa Healthcare, [2013]- |
| مواضيع طبية MeSH: | Drug Carriers/*chemistry , Indinavir/*administration & dosage , Indinavir/*pharmacokinetics , Nanoparticles/*chemistry , Polyesters/*chemistry , Polyethylene Glycols/*chemistry, Administration, Oral ; Animals ; Biological Availability ; Biological Transport ; Caco-2 Cells ; Drug Liberation ; Humans ; Indinavir/chemistry ; Indinavir/metabolism ; Male ; Particle Size ; Rats ; Rats, Sprague-Dawley ; Solubility ; Tissue Distribution |
| مستخلص: | Introduction: Indinavir (IDV) is a potent HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV). IDV is a weak base with limited aqueous solubility in its unprotonated form; therefore, solubility of IDV in the gastrointestinal tract fluids is the rate-limiting step of its absorption and onset of action. However, in many cases, drugs are not absorbed well in the gastrointestinal tract; polymer nanoparticles were recognized as an effective carrier system for drug encapsulation and are now studied as a vehicle for oral delivery of insoluble compounds. Preparation of methoxy poly (ethylene glycol)-poly (e-caprolactone) (mPEG-PCL) nanoparticles is among the strategies to overcome low bioavailability of drugs with poor aqueous solubility. Materials and method: The structure of the copolymers was characterized using 1 H NMR, FTIR, DSC and GPC techniques. IDV loaded mPEG- PCL nanoparticles prepared by emulsification solvent evaporation method were optimized using D-optimal experimental design and were characterized by various techniques such as DLS, DSC, XRD, AFM and SEM. Using Caco-2 cells as a cellular model, we studied the cellular uptake and transport. Results: In vivo pharmacokinetic studies were performed in rats. The plasma AUC (0- t ), t |
| فهرسة مساهمة: | Keywords: Indinavir; cellular uptake; mPEG-PCL nanoparticle; optimization; oral delivery; transport |
| المشرفين على المادة: | 0 (Drug Carriers) 0 (Polyesters) 0 (methoxy poly(ethylene glycol-co-epsilon-caprolactone)) 3WJQ0SDW1A (Polyethylene Glycols) 5W6YA9PKKH (Indinavir) |
| تواريخ الأحداث: | Date Created: 20190604 Date Completed: 20191118 Latest Revision: 20191118 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/21691401.2019.1616553 |
| PMID: | 31155961 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2169-141X |
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| DOI: | 10.1080/21691401.2019.1616553 |