دورية أكاديمية
Evaluation of the systemic and therapeutic repercussions caused by drug interactions in oncology patients.
| العنوان: | Evaluation of the systemic and therapeutic repercussions caused by drug interactions in oncology patients. |
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| المؤلفون: | Monteiro CRA; Faculty of Medicine of ABC, Santo André - SP, Brasil., Schoueri JHM; Faculty of Medicine of ABC, Santo André - SP, Brasil., Cardial DT; Faculty of Medicine of ABC, Santo André - SP, Brasil., Linhares LC; Faculty of Medicine of ABC, Santo André - SP, Brasil., Turke KC; Faculty of Medicine of ABC, Santo André - SP, Brasil., Steuer LV; Faculty of Medicine of ABC, Santo André - SP, Brasil., Menezes LWA; Faculty of Medicine of ABC, Santo André - SP, Brasil., Argani IL; Faculty of Medicine of ABC, Santo André - SP, Brasil., Sette C; Faculty of Medicine of ABC, Santo André - SP, Brasil., Cubero DIG; Faculty of Medicine of ABC, Santo André - SP, Brasil., Giglio AD; Faculty of Medicine of ABC, Santo André - SP, Brasil. |
| المصدر: | Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2019 Jun 03; Vol. 65 (5), pp. 611-617. Date of Electronic Publication: 2019 Jun 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Associação Médica Brasileira Country of Publication: Brazil NLM ID: 9308586 Publication Model: Electronic Cited Medium: Internet ISSN: 1806-9282 (Electronic) Linking ISSN: 01044230 NLM ISO Abbreviation: Rev Assoc Med Bras (1992) |
| أسماء مطبوعة: | Original Publication: São Paulo : Associação Médica Brasileira |
| مواضيع طبية MeSH: | Drug Interactions*, Antineoplastic Agents/*adverse effects , Drug-Related Side Effects and Adverse Reactions/*epidemiology, Adult ; Aged ; Aged, 80 and over ; Brazil/epidemiology ; Cross-Sectional Studies ; Female ; Hospitals, Public ; Humans ; Male ; Middle Aged ; Polypharmacy ; Risk Factors ; Severity of Illness Index ; Tertiary Care Centers |
| مستخلص: | Introduction: Drug interaction is an important cause of global morbidity. It is of particular importance in cancer patients since they are often in use of polypharmacy, related to interactions between the drugs and the chemotherapeutics used. Objective: To evaluate the drug interaction between chemotherapy and other drugs in cancer patients. Methods: a cross-sectional study carried out in the outpatient oncology department of a public tertiary hospital. Two hundred thirty-five patients were included, and the drugs they were using were identified. Using the MedScape and Epocrates database, we evaluated the interactions between medications and chemotherapy by defining their frequency and dividing their severity from interaction into mild, close monitoring necessity and severe. Results: 161 patients had some drug interaction. We identified 9 types of mild interactions, 23 types of interactions with close monitoring necessity, and 2 types of serious interactions. The most frequent interactions were between fluorouracil and leucovorin (32 cases) and cyclophosphamide and doxorubicin (19 cases). Serious interactions were between aspirin and pemetrexed; and leucovorin and Bactrim. Conclusion: In the present study, drug interactions were frequent, including serious interactions with a potential increase in morbidity and mortality. Thus, it is necessary for oncologists to draw up a therapeutic plan considering potential interactions between prescribed chemotherapy and current medications in use by patients. |
| المشرفين على المادة: | 0 (Antineoplastic Agents) |
| تواريخ الأحداث: | Date Created: 20190606 Date Completed: 20190726 Latest Revision: 20190726 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1590/1806-9282.65.5.611 |
| PMID: | 31166436 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1806-9282 |
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| DOI: | 10.1590/1806-9282.65.5.611 |