دورية أكاديمية
أعرض في EDS

Reaching the End of the Line: Urinary Tract Infections.

التفاصيل البيبلوغرافية
العنوان: Reaching the End of the Line: Urinary Tract Infections.
المؤلفون: Tamadonfar KO; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110., Omattage NS; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110., Spaulding CN; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.; Harvard University School of Public Health, Boston, MA 02115., Hultgren SJ; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.; Center for Women's Infectious Disease Research, Washington University, School of Medicine, St. Louis, MO 63110.
المصدر: Microbiology spectrum [Microbiol Spectr] 2019 May; Vol. 7 (3).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : ASM Press, 2013-
مواضيع طبية MeSH: Urinary Tract Infections/*drug therapy , Urinary Tract Infections/*microbiology , Uropathogenic Escherichia coli/*pathogenicity, Anti-Bacterial Agents/therapeutic use ; Catheter-Related Infections/microbiology ; Drug Resistance, Bacterial ; Enterococcus/pathogenicity ; Escherichia coli Infections/drug therapy ; Female ; Humans ; Staphylococcus/pathogenicity ; Urinary Bladder/microbiology ; Urinary Tract/microbiology ; Uropathogenic Escherichia coli/drug effects
مستخلص: Urinary tract infections (UTIs) cause a substantial health care burden. UTIs (i) are most often caused by uropathogenic Escherichia coli (UPEC), (ii) primarily affect otherwise healthy females (50% of women will have a UTI), (iii) are associated with significant morbidity and economic impact, (iv) can become chronic, and (v) are highly recurrent. A history of UTI is a significant risk factor for a recurrent UTI (rUTI). In otherwise healthy women, an acute UTI leads to a 25 to 50% chance of rUTI within months of the initial infection. Interestingly, rUTIs are commonly caused by the same strain of E. coli that led to the initial infection, arguing that there exist host-associated reservoirs, like the gastrointestinal tract and underlying bladder tissue, that can seed rUTIs. Additionally, catheter-associated UTIs (CAUTI), caused by Enterococcus and Staphylococcus as well as UPEC, represent a major health care concern. The host's response of depositing fibrinogen at the site of infection has been found to be critical to establishing CAUTI. The Drug Resistance Index, an evaluation of antibiotic resistance, indicates that UTIs have become increasingly difficult to treat since the mid-2000s. Thus, UTIs are a "canary in the coal mine," warning of the possibility of a return to the preantibiotic era, where some common infections are untreatable with available antibiotics. Numerous alternative strategies for both the prevention and treatment of UTIs are being pursued, with a focus on the development of vaccines and small-molecule inhibitors targeting virulence factors, in the hopes of reducing the burden of urogenital tract infections in an antibiotic-sparing manner.
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المشرفين على المادة: 0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20190608 Date Completed: 20200224 Latest Revision: 20240811
رمز التحديث: 20240812
مُعرف محوري في PubMed: PMC11314827
DOI: 10.1128/microbiolspec.BAI-0014-2019
PMID: 31172909
قاعدة البيانات: MEDLINE
الوصف
تدمد:2165-0497
DOI:10.1128/microbiolspec.BAI-0014-2019