دورية أكاديمية
Histoplasma capsulatum and Pneumocystis jirovecii coinfection in hospitalized HIV and non-HIV patients from a tertiary care hospital in Mexico.
| العنوان: | Histoplasma capsulatum and Pneumocystis jirovecii coinfection in hospitalized HIV and non-HIV patients from a tertiary care hospital in Mexico. |
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| المؤلفون: | Carreto-Binaghi LE; Laboratorio de Inmunología de Hongos, Unidad de Micología, Departamento de Microbiología-Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), CDMX, 04510, Mexico; Departamento de Investigación en Microbiología, Instituto Nacional de Enfermedades Respiratorias 'Ismael Cosío Villegas' (INER), CDMX, 14080, Mexico. Electronic address: lauraelena_c@yahoo.com., Morales-Villarreal FR; Departamento de Microbiología Clínica, INER, CDMX, 14080, Mexico. Electronic address: fernando62fmv@gmail.com., García-de la Torre G; Departamento de Salud Pública, Facultad de Medicina, UNAM, CDMX, 04510, Mexico. Electronic address: gsgarciadelatorre@gmail.com., Vite-Garín T; Laboratorio de Inmunología de Hongos, Unidad de Micología, Departamento de Microbiología-Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), CDMX, 04510, Mexico. Electronic address: tania.vite.garin@gmail.com., Ramirez JA; Laboratorio de Inmunología de Hongos, Unidad de Micología, Departamento de Microbiología-Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), CDMX, 04510, Mexico. Electronic address: anton100559@hotmail.com., Aliouat EM; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, Lille, France. Electronic address: elmoukhtar.aliouat-3@univ-lille2.fr., Martínez-Orozco JA; Departamento de Microbiología Clínica, INER, CDMX, 14080, Mexico. Electronic address: jarturoinfectologia@iner.gob.mx., Taylor ML; Laboratorio de Inmunología de Hongos, Unidad de Micología, Departamento de Microbiología-Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), CDMX, 04510, Mexico. Electronic address: emello@unam.mx. |
| المصدر: | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2019 Sep; Vol. 86, pp. 65-72. Date of Electronic Publication: 2019 Jun 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Canada NLM ID: 9610933 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3511 (Electronic) Linking ISSN: 12019712 NLM ISO Abbreviation: Int J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hamilton, ON : Elsevier Original Publication: Hamilton, ON : Decker, c1996- |
| مواضيع طبية MeSH: | Pneumocystis carinii*/genetics , Pneumocystis carinii*/isolation & purification, Coinfection/*epidemiology , Histoplasmosis/*epidemiology , Pneumonia, Pneumocystis/*epidemiology, Adult ; Aged ; Bronchoalveolar Lavage ; Female ; HIV Infections/complications ; Histoplasma/genetics ; Histoplasma/isolation & purification ; Histoplasmosis/microbiology ; Humans ; Male ; Mexico/epidemiology ; Middle Aged ; Pneumonia, Pneumocystis/microbiology ; Polymerase Chain Reaction ; Tertiary Care Centers |
| مستخلص: | Background: Histoplasma capsulatum and Pneumocystis jirovecii are respiratory fungal pathogens that principally cause pulmonary disease. Coinfection with both pathogens is scarcely reported. This study detected this coinfection using specific molecular methods for each fungus in the bronchoalveolar lavage (BAL) of patients from a tertiary care hospital. Materials and Methods: BAL samples from 289 hospitalized patients were screened by PCR with specific markers for H. capsulatum (Hcp100) and P. jirovecii (mtLSUrRNA and mtSSUrRNA). The presence of these pathogens was confirmed by the generated sequences for each marker. The clinical and laboratory data for the patients were analyzed using statistical software. Results: The PCR findings separated three groups of patients, where the first was represented by 60 (20.8%) histoplasmosis patients, the second by 45 (15.6%) patients with pneumocystosis, and the last group by 12 (4.2%) patients with coinfection. High similarity among the generated sequences of each species was demonstrated by BLASTn and neighbor-joining algorithms. The estimated prevalence of H. capsulatum and P. jirovecii coinfection was higher in HIV patients. (Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| التعليقات: | Comment in: Int J Infect Dis. 2019 Oct;87:126-127. (PMID: 31442626) |
| فهرسة مساهمة: | Keywords: Bronchoalveolar lavage; Coinfection; Histoplasmosis; Molecular diagnosis; Pneumocystosis |
| تواريخ الأحداث: | Date Created: 20190618 Date Completed: 20200224 Latest Revision: 20200224 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.ijid.2019.06.010 |
| PMID: | 31207386 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1878-3511 |
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| DOI: | 10.1016/j.ijid.2019.06.010 |