دورية أكاديمية
أعرض في EDS

Hepatosplenic αβ T-Cell Lymphoma as Second Malignancy in Young Adult Patient With Previously Undiagnosed Ataxia-Telangiectasia.

التفاصيل البيبلوغرافية
العنوان: Hepatosplenic αβ T-Cell Lymphoma as Second Malignancy in Young Adult Patient With Previously Undiagnosed Ataxia-Telangiectasia.
المؤلفون: Jacobs MF; Departments of Internal Medicine.; Comprehensive Cancer Center., Anderson B; Pediatrics., Opipari VP; Pediatrics.; Comprehensive Cancer Center., Mody R; Pediatrics.; Comprehensive Cancer Center.; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI.
المصدر: Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2020 Aug; Vol. 42 (6), pp. e463-e465.
نوع المنشور: Case Reports; Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505928 Publication Model: Print Cited Medium: Internet ISSN: 1536-3678 (Electronic) Linking ISSN: 10774114 NLM ISO Abbreviation: J Pediatr Hematol Oncol Subsets: MEDLINE
أسماء مطبوعة: Publication: 1998- : Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: New York, NY : Raven Press, c1995-
مواضيع طبية MeSH: Ataxia Telangiectasia/*complications , Liver Neoplasms/*pathology , Lymphoma, T-Cell/*pathology , Neoplasms, Second Primary/*pathology , Receptors, Antigen, T-Cell, alpha-beta/*immunology , Splenic Neoplasms/*pathology, Adolescent ; Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Female ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/etiology ; Lymphoma, T-Cell/drug therapy ; Lymphoma, T-Cell/etiology ; Neoplasms, Second Primary/drug therapy ; Neoplasms, Second Primary/etiology ; Prognosis ; Splenic Neoplasms/drug therapy ; Splenic Neoplasms/etiology ; Young Adult
مستخلص: Ataxia-telangiectasia is a rare autosomal recessive neurodegenerative disease characterized by ataxia, radiosensitivity, telangiectases, and increased risk for hematologic malignancies. We present a case of a female individual diagnosed with T-cell acute lymphocytic leukemia at 13 years and subsequently with αβ subtype of hepatosplenic T-cell lymphoma (HSTCL) at 20 years. During her diagnostic work up for HSTCL, paired tumor-germline sequencing identified a diagnosis of ataxia-telangiectasia. We also describe a very refractory clinical course of her αβ HSTCL, including only a brief response to multiagent chemotherapy and an allogenic bone marrow transplant.
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معلومات مُعتمدة: UM1 HG006508 United States HG NHGRI NIH HHS
المشرفين على المادة: 0 (Receptors, Antigen, T-Cell, alpha-beta)
تواريخ الأحداث: Date Created: 20190702 Date Completed: 20201231 Latest Revision: 20221005
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6933092
DOI: 10.1097/MPH.0000000000001537
PMID: 31259827
قاعدة البيانات: MEDLINE
الوصف
تدمد:1536-3678
DOI:10.1097/MPH.0000000000001537