دورية أكاديمية
Hepatosplenic αβ T-Cell Lymphoma as Second Malignancy in Young Adult Patient With Previously Undiagnosed Ataxia-Telangiectasia.
العنوان: | Hepatosplenic αβ T-Cell Lymphoma as Second Malignancy in Young Adult Patient With Previously Undiagnosed Ataxia-Telangiectasia. |
---|---|
المؤلفون: | Jacobs MF; Departments of Internal Medicine.; Comprehensive Cancer Center., Anderson B; Pediatrics., Opipari VP; Pediatrics.; Comprehensive Cancer Center., Mody R; Pediatrics.; Comprehensive Cancer Center.; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI. |
المصدر: | Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2020 Aug; Vol. 42 (6), pp. e463-e465. |
نوع المنشور: | Case Reports; Journal Article; Research Support, N.I.H., Extramural |
اللغة: | English |
بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505928 Publication Model: Print Cited Medium: Internet ISSN: 1536-3678 (Electronic) Linking ISSN: 10774114 NLM ISO Abbreviation: J Pediatr Hematol Oncol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 1998- : Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: New York, NY : Raven Press, c1995- |
مواضيع طبية MeSH: | Ataxia Telangiectasia/*complications , Liver Neoplasms/*pathology , Lymphoma, T-Cell/*pathology , Neoplasms, Second Primary/*pathology , Receptors, Antigen, T-Cell, alpha-beta/*immunology , Splenic Neoplasms/*pathology, Adolescent ; Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Female ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/etiology ; Lymphoma, T-Cell/drug therapy ; Lymphoma, T-Cell/etiology ; Neoplasms, Second Primary/drug therapy ; Neoplasms, Second Primary/etiology ; Prognosis ; Splenic Neoplasms/drug therapy ; Splenic Neoplasms/etiology ; Young Adult |
مستخلص: | Ataxia-telangiectasia is a rare autosomal recessive neurodegenerative disease characterized by ataxia, radiosensitivity, telangiectases, and increased risk for hematologic malignancies. We present a case of a female individual diagnosed with T-cell acute lymphocytic leukemia at 13 years and subsequently with αβ subtype of hepatosplenic T-cell lymphoma (HSTCL) at 20 years. During her diagnostic work up for HSTCL, paired tumor-germline sequencing identified a diagnosis of ataxia-telangiectasia. We also describe a very refractory clinical course of her αβ HSTCL, including only a brief response to multiagent chemotherapy and an allogenic bone marrow transplant. |
References: | J Hum Genet. 2017 Apr;62(5):581-584. (PMID: 28123174) Int J Cancer. 2005 May 10;114(6):909-16. (PMID: 15645496) JAMA. 2015 Sep 1;314(9):913-25. (PMID: 26325560) Am J Hum Genet. 1986 Nov;39(5):573-83. (PMID: 3788973) J Clin Pathol. 2001 Jul;54(7):512-6. (PMID: 11429421) J Clin Pathol. 2005 Oct;58(10):1009-15. (PMID: 16189143) Ann Diagn Pathol. 2017 Feb;26:16-22. (PMID: 28038706) Am J Surg Pathol. 2001 Mar;25(3):285-96. (PMID: 11224598) Hum Mutat. 2012 Mar;33(3):561-71. (PMID: 22213089) J Invest Dermatol. 2014 Mar;134(3):849-852. (PMID: 24042343) Indian J Hematol Blood Transfus. 2014 Sep;30(Suppl 1):21-3. (PMID: 25332524) J Neurol Sci. 2015 Aug 15;355(1-2):3-6. (PMID: 26050521) JAMA. 2018 Jun 19;319(23):2401-2409. (PMID: 29922827) Eur J Hum Genet. 2006 Nov;14(11):1158-69. (PMID: 16724013) Int J Clin Oncol. 2010 Apr;15(2):215-9. (PMID: 20217452) Br J Cancer. 2011 Aug 9;105(4):586-91. (PMID: 21792198) J Natl Cancer Inst. 2001 Jan 17;93(2):121-7. (PMID: 11208881) Eur J Hum Genet. 2018 Sep;26(9):1392-1395. (PMID: 29891879) Bone Marrow Transplant. 2007 Apr;39(8):513-4. (PMID: 17310131) |
معلومات مُعتمدة: | UM1 HG006508 United States HG NHGRI NIH HHS |
المشرفين على المادة: | 0 (Receptors, Antigen, T-Cell, alpha-beta) |
تواريخ الأحداث: | Date Created: 20190702 Date Completed: 20201231 Latest Revision: 20221005 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC6933092 |
DOI: | 10.1097/MPH.0000000000001537 |
PMID: | 31259827 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1536-3678 |
---|---|
DOI: | 10.1097/MPH.0000000000001537 |