دورية أكاديمية
أعرض في EDS

mEAK-7 Forms an Alternative mTOR Complex with DNA-PKcs in Human Cancer.

التفاصيل البيبلوغرافية
العنوان: mEAK-7 Forms an Alternative mTOR Complex with DNA-PKcs in Human Cancer.
المؤلفون: Nguyen JT; Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48105, USA., Haidar FS; Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48105, USA., Fox AL; Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48105, USA., Ray C; Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48105, USA., Mendonça DB; Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA., Kim JK; Section of Periodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA., Krebsbach PH; Section of Periodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: pkrebsbach@dentistry.ucla.edu.
المصدر: IScience [iScience] 2019 Jul 26; Vol. 17, pp. 190-207. Date of Electronic Publication: 2019 Jun 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, [2018]-
مستخلص: MTOR associated protein, eak-7 homolog (mEAK-7), activates mechanistic target of rapamycin (mTOR) signaling in human cells through an alternative mTOR complex to regulate S6K2 and 4E-BP1. However, the role of mEAK-7 in human cancer has not yet been identified. We demonstrate that mEAK-7 and mTOR signaling are strongly elevated in tumor and metastatic lymph nodes of patients with non-small-cell lung carcinoma compared with those of patients with normal lung or lymph tissue. Cancer stem cells, CD44+/CD90+ cells, yield elevated mEAK-7 and activated mTOR signaling. mEAK-7 is required for clonogenic potential and spheroid formation. mEAK-7 associates with DNA-dependent protein kinase catalytic subunit isoform 1 (DNA-PKcs), and this interaction is increased in response to X-ray irradiation to regulate S6K2 signaling. DNA-PKcs pharmacologic inhibition or genetic knockout reduced S6K2, mEAK-7, and mTOR binding with DNA-PKcs, resulting in loss of S6K2 activity and mTOR signaling. Therefore, mEAK-7 forms an alternative mTOR complex with DNA-PKcs to regulate S6K2 in human cancer cells.
(Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: F30 DE026048 United States DE NIDCR NIH HHS; R01 DE016530 United States DE NIDCR NIH HHS; T32 DE007057 United States DE NIDCR NIH HHS
فهرسة مساهمة: Keywords: Biological Sciences; Cancer; Cell Biology
تواريخ الأحداث: Date Created: 20190710 Latest Revision: 20200930
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6614755
DOI: 10.1016/j.isci.2019.06.029
PMID: 31288154
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-0042
DOI:10.1016/j.isci.2019.06.029