دورية أكاديمية
A multi-centre evaluation of malignant odontogenic tumours in Nigeria.
| العنوان: | A multi-centre evaluation of malignant odontogenic tumours in Nigeria. |
|---|---|
| المؤلفون: | Soyele OO; Department of Oral Maxillofacial Surgery and Oral Pathology, Obafemi Awolowo University, Ile-Ife, Nigeria., Effiom OA; Department of Oral and Maxillofacial Pathology and Biology, College of Medicine, University of Lagos, Lagos, Nigeria., Lawal AO; Department of Oral Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria., Nwoga MC; Oral Pathology Unit, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry University of Nigeria, Enugu, Nigeria., Adebiyi KE; Department of Oral Pathology and Oral Medicine, Faculty of Dentistry, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria., Aborisade A; Department of Oral and Maxillofacial Surgery and Oral Pathology, Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Nigeria., Olatunji AS; Department of Oral and Maxillofacial Surgery and Oral Pathology, Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Nigeria., Olawuyi AB; Department of Oral and Maxillofacial Pathology and Biology, Lagos University Teaching Hospital, Lagos, Nigeria., Ladeji AM; Department of Oral Pathology and Oral Medicine, Faculty of Dentistry, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria., Okiti RO; Department of Oral Pathology, University College Hospital, Ibadan, Nigeria., Adeola HA; Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, University of the Western Cape and Tygerberg Hospital, Cape Town, South Africa.; Division of Dermatology, Department of Medicine, Faculty of Health Sciences and Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa. |
| المصدر: | The Pan African medical journal [Pan Afr Med J] 2019 May 10; Vol. 33, pp. 18. Date of Electronic Publication: 2019 May 10 (Print Publication: 2019). |
| نوع المنشور: | Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: African Field Epidemiology Network Country of Publication: Uganda NLM ID: 101517926 Publication Model: eCollection Cited Medium: Internet ISSN: 1937-8688 (Electronic) NLM ISO Abbreviation: Pan Afr Med J |
| أسماء مطبوعة: | Original Publication: Kampala, Uganda : African Field Epidemiology Network |
| مواضيع طبية MeSH: | Ameloblastoma/*epidemiology , Carcinosarcoma/*epidemiology , Jaw Neoplasms/*epidemiology , Odontogenic Tumors/*epidemiology, Adolescent ; Adult ; Age Factors ; Aged ; Ameloblastoma/diagnosis ; Ameloblastoma/pathology ; Biopsy/methods ; Carcinosarcoma/diagnosis ; Carcinosarcoma/pathology ; Child ; Child, Preschool ; Female ; Humans ; Jaw Neoplasms/diagnosis ; Jaw Neoplasms/pathology ; Male ; Middle Aged ; Nigeria/epidemiology ; Odontogenic Tumors/diagnosis ; Odontogenic Tumors/pathology ; Retrospective Studies ; Young Adult |
| مستخلص: | Introduction: odontogenic tumors originate from neoplastic transformation of the remnants of tooth forming apparatus. There are varying degrees of inductive interactions between odontogenic ectomesenchyme and epithelium during odontogenesis, leading to lesions that vary from benign to malignant. Malignant odontogenic tumours (MOTs) are very rare and are classified according to embryonic tissue of origin. Recently, there has been a few changes to the classification of MOTs according to the World Health Organization's (WHO) classification in 2017. This study aims to evaluate and reclassify MOTs, using a multi-centre approach in some major tertiary dental hospitals in Nigeria. Methods: this study reviewed the clinicopathological data on 63 cases of MOT diagnosed over 25 years in five major tertiary dental hospitals in Nigeria. All MOT cases were reclassified according to the recent revision to the 2017 WHO classification of odontogenic tumours. Results: from a total of 10,446 biopsies of oral and jaw lesions seen at the 5 study centres over the 25-year study period, 2199 (21.05%) cases were found to be odontogenic tumours (OTs), of which 63 were MOT. MOTs constituted 0.60% of the total biopsy cases and 2.86% of OTs. Odontogenic carcinomas presented with a mean age higher than odontogenic sarcomas. According to our 2017 WHO reclassification of MOTs, odontogenic carcinomas, ameloblastic carcinomas and primary intraosseous carcinomas were found to be the top three lesions, respectively. Carcinosarcomas were found to be extremely rare. Conclusion: using a multi-centre approach is a robust way to reduce diagnostic challenges associated with rare maxillofacial lesions such as MOTs. Competing Interests: The authors declare no competing interests. |
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| فهرسة مساهمة: | Keywords: Nigeria; Odontogenic tumour; head and neck; malignant; multi-centre |
| تواريخ الأحداث: | Date Created: 20190718 Date Completed: 20190724 Latest Revision: 20220409 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6615768 |
| DOI: | 10.11604/pamj.2019.33.18.16179 |
| PMID: | 31312334 |
| قاعدة البيانات: | MEDLINE |
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