دورية أكاديمية
أعرض في EDS

Role of hypoxia-inducible factor 1α as a potential biomarker for renal diseases-A systematic review.

التفاصيل البيبلوغرافية
العنوان: Role of hypoxia-inducible factor 1α as a potential biomarker for renal diseases-A systematic review.
المؤلفون: Encinas JFA; Department of Clinical Analysis, Faculdade de Medicina do ABC/FMABC - Santo André, Santo André, Brazil., Foncesca CH; Department of Clinical Analysis, Faculdade de Medicina do ABC/FMABC - Santo André, Santo André, Brazil., Perez MM; Department of Clinical Analysis, Faculdade de Medicina do ABC/FMABC - Santo André, Santo André, Brazil., Simões DP; Department of Clinical Analysis, Faculdade de Medicina do ABC/FMABC - Santo André, Santo André, Brazil.; Universidade Municipal de São Caetano do Sul/USCS - São Caetano do Sul, Sao Caetano do Sul, Brazil., da Costa Aguiar Alves B; Department of Clinical Analysis, Faculdade de Medicina do ABC/FMABC - Santo André, Santo André, Brazil., Bacci MR; Department of Clinical Analysis, Faculdade de Medicina do ABC/FMABC - Santo André, Santo André, Brazil., Maifrino LBM; Universidade São Judas Tadeu, São Paulo, Brazil., Fonseca FLA; Department of Clinical Analysis, Faculdade de Medicina do ABC/FMABC - Santo André, Santo André, Brazil.; Universidade Federal de São Paulo/UNIFESP - Diadema, São Paulo, Brazil., da Veiga GL; Department of Clinical Analysis, Faculdade de Medicina do ABC/FMABC - Santo André, Santo André, Brazil.
المصدر: Cell biochemistry and function [Cell Biochem Funct] 2019 Aug; Vol. 37 (6), pp. 443-451. Date of Electronic Publication: 2019 Jul 18.
نوع المنشور: Journal Article; Systematic Review
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 8305874 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0844 (Electronic) Linking ISSN: 02636484 NLM ISO Abbreviation: Cell Biochem Funct Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, England : Wiley-Blackwell
Original Publication: Guildford, Surrey : Butterworth Scientific Ltd., c1983-
مواضيع طبية MeSH: Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism , Kidney Diseases/*metabolism, Animals ; Biomarkers/metabolism ; Humans ; Kidney Diseases/pathology
مستخلص: Renal cells need oxygen for homeostasis; it is known for adjusting cellular functioning and the energy obtainment have a broad relationship with cellular respiration, through the O 2 bioavailability. O 2 homeostasis regulation in the kidney is mediated by hypoxia-inducible factors (HIFs). HIF is divided into three α isoforms, represented by HIF-1α, HIF-2α, and HIF-3α in addition to three paralogs of HIF-1β; these are involved in some metabolic processes, as well as in the pathogenesis of several diseases. Renal biopsy analyses of patients and experimental animal models aim to understand the relationship between HIF and protection against developing renal diseases or the induction of their onset, being thus this molecule can be considered a potential biomarker of renal disease. We carried out a systematic review to which we included studies on HIF-1α and renal disease in the last 5 years (2013-2018) in researches with humans and/or animal model through searches in three databases: LILACS, PubMed, and SciELO by two researchers. We obtained 22 articles that discussed the relationship with HIF as inductor or protector against renal disease and no relation between HIF and renal. We observed controversies remain regarding the relation between of HIF with renal diseases; this may be related to the different intracellular pathways mediated by HIF-1α, thereby determining differentiated cellular responses.
(© 2019 John Wiley & Sons, Ltd.)
فهرسة مساهمة: Keywords: biomarkers; hypoxia; hypoxia-induced factor; nephropathy; review
المشرفين على المادة: 0 (Biomarkers)
0 (Hypoxia-Inducible Factor 1, alpha Subunit)
تواريخ الأحداث: Date Created: 20190719 Date Completed: 20190909 Latest Revision: 20190909
رمز التحديث: 20231215
DOI: 10.1002/cbf.3425
PMID: 31317578
قاعدة البيانات: MEDLINE
الوصف
تدمد:1099-0844
DOI:10.1002/cbf.3425