دورية أكاديمية
Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy.
العنوان: | Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy. |
---|---|
المؤلفون: | Dorsch LM; Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, 1081 HV Amsterdam, The Netherlands. l.dorsch@vumc.nl., Schuldt M; Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, 1081 HV Amsterdam, The Netherlands., dos Remedios CG; Sydney Heart Bank, Discipline of Anatomy, Bosch Institute, University of Sydney, Sydney 2006, Australia., Schinkel AFL; Department of Cardiology, Thoraxcenter, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands., de Jong PL; Department of Cardiothoracic Surgery, Thoraxcenter, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands., Michels M; Department of Cardiology, Thoraxcenter, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands., Kuster DWD; Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, 1081 HV Amsterdam, The Netherlands., Brundel BJJM; Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, 1081 HV Amsterdam, The Netherlands., van der Velden J; Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, 1081 HV Amsterdam, The Netherlands.; Netherlands Heart Institute, 3511 EP Utrecht, The Netherlands. |
المصدر: | Cells [Cells] 2019 Jul 18; Vol. 8 (7). Date of Electronic Publication: 2019 Jul 18. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
مواضيع طبية MeSH: | Unfolded Protein Response*, Cardiomyopathy, Hypertrophic/*metabolism , Microtubules/*metabolism, Adult ; Aged ; Cardiomyopathy, Hypertrophic/genetics ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Chaperonin 60/metabolism ; Female ; HSP70 Heat-Shock Proteins/metabolism ; Humans ; Male ; Microtubules/genetics ; Middle Aged ; Mitochondrial Proteins/metabolism ; Mutation ; Myocytes, Cardiac/metabolism ; Sarcomeres/genetics ; Sarcomeres/metabolism ; Tubulin/metabolism |
مستخلص: | Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disorder. It is mainly caused by mutations in genes encoding sarcomere proteins. Mutant forms of these highly abundant proteins likely stress the protein quality control (PQC) system of cardiomyocytes. The PQC system, together with a functional microtubule network, maintains proteostasis. We compared left ventricular (LV) tissue of nine donors (controls) with 38 sarcomere mutation-positive (HCM Competing Interests: The authors declare no conflict of interest. |
References: | Circ Heart Fail. 2021 Jan;14(1):e007022. (PMID: 33430602) Cardiovasc Res. 2016 Nov 01;112(2):543-554. (PMID: 27557636) J Mol Cell Cardiol. 2015 Aug;85:262-72. (PMID: 26100051) Future Cardiol. 2008 Mar;4(2):151-61. (PMID: 19804293) J Gen Physiol. 2019 Jan 7;151(1):18-29. (PMID: 30578328) J Muscle Res Cell Motil. 2017 Aug;38(3-4):291-302. (PMID: 29101517) Circ Cardiovasc Genet. 2010 Apr;3(2):138-46. (PMID: 20124440) Hum Mol Genet. 2010 Dec 1;19(23):4677-93. (PMID: 20843828) Biophys J. 2018 Nov 6;115(9):1796-1807. (PMID: 30322798) Circ Res. 1998 Jul 27;83(2):117-32. (PMID: 9686751) EMBO J. 2002 Dec 16;21(24):6820-31. (PMID: 12486003) Biochim Biophys Acta. 2013 Feb;1833(2):410-6. (PMID: 22445420) Circ Genom Precis Med. 2018 Dec;11(12):e001974. (PMID: 30562113) Cell. 2015 Jun 18;161(7):1566-75. (PMID: 26073943) Circ Heart Fail. 2013 Jan;6(1):136-44. (PMID: 23152488) J Biol Chem. 2010 Jul 30;285(31):24184-94. (PMID: 20484055) Circulation. 2000 Aug 22;102(8):858-64. (PMID: 10952953) Circ Heart Fail. 2012 Jan;5(1):36-46. (PMID: 22178992) Nat Rev Genet. 2005 Sep;6(9):678-87. (PMID: 16074985) Cardiovasc Res. 2013 Sep 1;99(4):648-56. (PMID: 23764881) Circ Res. 2006 Dec 8;99(12):1315-28. (PMID: 17158347) J Mol Cell Cardiol. 1998 Apr;30(4):811-8. (PMID: 9602430) Acta Pharmacol Sin. 2014 Aug;35(8):1005-14. (PMID: 24998254) J Biol Chem. 2011 Jan 14;286(2):1576-87. (PMID: 21056972) J Mol Cell Cardiol. 2010 Nov;49(5):737-45. (PMID: 20615414) Curr Opin Cell Biol. 2014 Feb;26:139-146. (PMID: 24463332) Circulation. 1996 Mar 15;93(6):1230-43. (PMID: 8653846) Arch Biochem Biophys. 1994 May 1;310(2):428-32. (PMID: 8179328) N Engl J Med. 2013 Jan 31;368(5):455-64. (PMID: 23363499) Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1446-51. (PMID: 23302686) JCI Insight. 2018 Jun 7;3(11):. (PMID: 29875314) Circulation. 2008 Jun 17;117(24):3070-8. (PMID: 18541737) Arch Biochem Biophys. 2016 Jul 1;601:113-20. (PMID: 27036851) Circulation. 2010 Apr 6;121(13):1474-83. (PMID: 20308615) J Physiol. 2014 Aug 1;592(15):3257-72. (PMID: 24928957) Autophagy. 2013 Oct;9(10):1455-66. (PMID: 23959233) Sci Transl Med. 2015 Apr 1;7(281):281ra45. (PMID: 25834111) J Struct Biol. 2001 Aug;135(2):219-29. (PMID: 11580271) Am J Pathol. 2017 Dec;187(12):2645-2658. (PMID: 28935576) Nat Commun. 2018 Jan 17;9(1):262. (PMID: 29343782) Cardiovasc Res. 2014 Jul 15;103(2):248-57. (PMID: 24835277) JACC Basic Transl Sci. 2018 Jun 25;3(3):335-346. (PMID: 30062220) Circ Res. 2008 Dec 5;103(12):1473-82. (PMID: 18974385) Front Physiol. 2018 Apr 09;9:359. (PMID: 29686627) Eur Heart J. 2009 Aug;30(15):1853-62. (PMID: 19468012) Cell Mol Life Sci. 2015 Nov;72(22):4237-55. (PMID: 26227334) Am J Physiol Heart Circ Physiol. 2013 May 15;304(10):H1283-93. (PMID: 23479263) Eur Heart J. 2011 May;32(9):1065-76. (PMID: 21459883) Circ Cardiovasc Genet. 2008 Dec;1(2):117-25. (PMID: 20031553) J Mol Cell Cardiol. 2008 Jul;45(1):11-27. (PMID: 18495153) Cell Stress Chaperones. 2017 Jul;22(4):517-529. (PMID: 28144778) Future Med Chem. 2016 Dec;8(18):2177-2183. (PMID: 27845575) Cell. 2001 Feb 23;104(4):557-67. (PMID: 11239412) Circ Heart Fail. 2017 Oct;10(10):. (PMID: 29030372) Circ Res. 2000 Apr 28;86(8):846-53. (PMID: 10785506) Cell Stress Chaperones. 2007 Summer;12(2):163-71. (PMID: 17688195) J Mol Cell Cardiol. 2015 May;82:93-103. (PMID: 25771144) J Mol Cell Cardiol. 2010 Sep;49(3):370-9. (PMID: 20600103) Proteomics Clin Appl. 2009 Dec;3(12):1371-82. (PMID: 21136957) Circ Heart Fail. 2018 Jun;11(6):e004133. (PMID: 29853478) Hum Mol Genet. 1994 Oct;3(10):1819-22. (PMID: 7849706) Circulation. 2009 Mar 24;119(11):1473-83. (PMID: 19273718) Am J Physiol Cell Physiol. 2002 Mar;282(3):C617-24. (PMID: 11832347) Cell Biol Int. 2005 Jan;29(1):51-5. (PMID: 15763499) Dev Biol. 2018 Mar 1;435(1):41-55. (PMID: 29331499) J Am Coll Cardiol. 2015 Mar 31;65(12):1249-1254. (PMID: 25814232) Circ Res. 2013 May 24;112(11):1491-505. (PMID: 23508784) Basic Res Cardiol. 2004 Nov;99(6):392-4. (PMID: 15309411) Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):E5178-86. (PMID: 25404307) Cardiovasc Res. 2013 Aug 1;99(3):432-41. (PMID: 23674513) PLoS One. 2013 Oct 07;8(10):e74847. (PMID: 24116014) Front Physiol. 2018 Jan 19;8:1111. (PMID: 29403388) Science. 2017 Apr 21;356(6335):328-332. (PMID: 28428427) Cardiovasc Res. 2013 Mar 1;97(3):500-8. (PMID: 23097574) Circulation. 2018 Oct 2;138(14):1387-1398. (PMID: 30297972) J Biol Chem. 2018 Jun 1;293(22):8588-8599. (PMID: 29669813) Eur J Heart Fail. 2007 Aug;9(8):762-9. (PMID: 17481944) Circulation. 2012 Oct 9;126(15):1828-37. (PMID: 22972900) J Mol Cell Cardiol. 2013 Dec;65:59-66. (PMID: 24083979) Proteomics. 2011 Sep;11(17):3582-6. (PMID: 21751342) Neth Heart J. 2017 Mar;25(3):186-199. (PMID: 28005231) Circ Res. 2009 Jul 31;105(3):219-22. (PMID: 19574547) Am J Cardiol. 2015 Mar 1;115(5):670-5. (PMID: 25591899) Pflugers Arch. 2019 May;471(5):795-806. (PMID: 30109411) J Mol Cell Cardiol. 2018 Oct;123:59-63. (PMID: 30170119) Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2238-47. (PMID: 17675567) Nat Rev Cardiol. 2017 Nov;14(11):637-653. (PMID: 28660894) Adv Exp Med Biol. 2008;642:1-14. (PMID: 19181089) PLoS One. 2017 Jun 28;12(6):e0180064. (PMID: 28658286) J Biol Chem. 2014 Apr 25;289(17):11816-11828. (PMID: 24619423) Science. 2016 Apr 22;352(6284):aaf0659. (PMID: 27102488) Hypertension. 2010 Jun;55(6):1412-7. (PMID: 20439823) Circ Res. 2006 Oct 27;99(9):1012-20. (PMID: 17023673) Circ Res. 1987 Mar;60(3):327-36. (PMID: 2953507) Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1322-33. (PMID: 12234782) Am J Cardiol. 2016 Sep 15;118(6):881-887. (PMID: 27476098) Pflugers Arch. 2014 Aug;466(8):1619-33. (PMID: 24186209) Eur J Cell Biol. 1984 Jul;34(2):300-6. (PMID: 6236978) Circ Res. 2009 Jan 2;104(1):87-94. (PMID: 19023132) Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E7003-12. (PMID: 26621701) Nature. 2002 May 23;417(6887):455-8. (PMID: 12024216) Exp Cell Res. 1996 Jan 10;222(1):16-27. (PMID: 8549659) Cardiovasc Res. 2001 Sep;51(4):637-46. (PMID: 11530097) Circ Res. 2008 Nov 21;103(11):1259-69. (PMID: 18849323) Dev Cell. 2016 Nov 21;39(4):466-479. (PMID: 27720608) BMC Evol Biol. 2008 Jan 23;8:19. (PMID: 18215318) Physiol Rev. 2019 Jan 1;99(1):381-426. (PMID: 30379622) |
فهرسة مساهمة: | Keywords: autophagy; cardiomyopathy; haploinsufficiency; heat shock proteins; hypertrophy; microtubules; poison polypeptide; protein quality control; sarcomere mutation |
المشرفين على المادة: | 0 (Carrier Proteins) 0 (Chaperonin 60) 0 (HSP70 Heat-Shock Proteins) 0 (HSPA2 protein, human) 0 (HSPD1 protein, human) 0 (Mitochondrial Proteins) 0 (Tubulin) 0 (myosin-binding protein C) |
تواريخ الأحداث: | Date Created: 20190721 Date Completed: 20200210 Latest Revision: 20231013 |
رمز التحديث: | 20231013 |
مُعرف محوري في PubMed: | PMC6678711 |
DOI: | 10.3390/cells8070741 |
PMID: | 31323898 |
قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!