دورية أكاديمية
Pharmacological Characterization and Investigation of N-Terminal Loop Amino Acids of Adrenomedullin 2 That Are Important for Receptor Activation.
| العنوان: | Pharmacological Characterization and Investigation of N-Terminal Loop Amino Acids of Adrenomedullin 2 That Are Important for Receptor Activation. |
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| المؤلفون: | Musa H; School of Biological Sciences , The University of Auckland , 3A Symonds Street , Auckland 1010 , New Zealand., Hendrikse ER; School of Biological Sciences , The University of Auckland , 3A Symonds Street , Auckland 1010 , New Zealand., Brimble MA; School of Biological Sciences , The University of Auckland , 3A Symonds Street , Auckland 1010 , New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery , The University of Auckland , 3A Symonds Street , Auckland 1010 , New Zealand.; School of Chemical Sciences , The University of Auckland , 23 Symonds Street , Auckland 1010 , New Zealand., Garelja ML; School of Biological Sciences , The University of Auckland , 3A Symonds Street , Auckland 1010 , New Zealand., Watkins HA; School of Biological Sciences , The University of Auckland , 3A Symonds Street , Auckland 1010 , New Zealand., Harris PWR; School of Biological Sciences , The University of Auckland , 3A Symonds Street , Auckland 1010 , New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery , The University of Auckland , 3A Symonds Street , Auckland 1010 , New Zealand.; School of Chemical Sciences , The University of Auckland , 23 Symonds Street , Auckland 1010 , New Zealand., Hay DL; School of Biological Sciences , The University of Auckland , 3A Symonds Street , Auckland 1010 , New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery , The University of Auckland , 3A Symonds Street , Auckland 1010 , New Zealand. |
| المصدر: | Biochemistry [Biochemistry] 2019 Aug 13; Vol. 58 (32), pp. 3468-3474. Date of Electronic Publication: 2019 Jul 29. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Chemical Society. |
| مواضيع طبية MeSH: | Adrenomedullin/*chemistry , Adrenomedullin/*metabolism , Receptors, Cell Surface/*metabolism, Amino Acid Sequence ; Animals ; COS Cells ; Chlorocebus aethiops ; Cyclic AMP/biosynthesis ; Humans |
| مستخلص: | Adrenomedullin 2 (AM2) is a peptide hormone with potent effects in the cardiovascular system. The N-terminal disulfide loop of AM2 is thought to be important for interacting with its receptors to initiate a signaling response. However, the relative contribution of each amino acid within this region is currently unknown. Thus, the region was investigated using an alanine scanning approach. Two AM2 peptides (AM2-47 and AM2-40) were directly compared at the CGRP, AM |
| المشرفين على المادة: | 0 (Receptors, Cell Surface) 148498-78-6 (Adrenomedullin) E0399OZS9N (Cyclic AMP) |
| تواريخ الأحداث: | Date Created: 20190723 Date Completed: 20200605 Latest Revision: 20200605 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1021/acs.biochem.9b00571 |
| PMID: | 31328503 |
| قاعدة البيانات: | MEDLINE |
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