دورية أكاديمية
Acute treatment with Mangifera indica L. leaf extract attenuates liver inflammation in rats fed a cafeteria diet.
| العنوان: | Acute treatment with Mangifera indica L. leaf extract attenuates liver inflammation in rats fed a cafeteria diet. |
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| المؤلفون: | Toledo RCL; Departament of Nutrition and Health. Federal University of Viçosa, Av. Purdue, s/n, Campus Universitário, Viçosa, MG 36.570-900, Brazil. renatacelly@yahoo.com.br., Brito LF, Caetano MMM, Nakajima VM, da Silva BP, Soares FEF, Martino HSD, de Queiroz JH |
| المصدر: | Food & function [Food Funct] 2019 Aug 01; Vol. 10 (8), pp. 4861-4867. Date of Electronic Publication: 2019 Jul 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101549033 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2042-650X (Electronic) Linking ISSN: 20426496 NLM ISO Abbreviation: Food Funct Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Anti-Inflammatory Agents/*administration & dosage , Liver Diseases/*drug therapy , Mangifera/*chemistry , Plant Extracts/*administration & dosage, Animals ; Diet, High-Fat/adverse effects ; Humans ; Interleukin-10/genetics ; Interleukin-10/immunology ; Liver/drug effects ; Liver/immunology ; Liver Diseases/etiology ; Liver Diseases/genetics ; Liver Diseases/immunology ; Male ; Malondialdehyde/immunology ; PPAR alpha/genetics ; PPAR alpha/immunology ; Phytotherapy ; Plant Leaves/chemistry ; Rats |
| مستخلص: | This study investigates the acute anti-inflammatory activity of Mangifera indica L. leaf extract and mangiferin in the liver of rats fed a cafeteria diet. This study was a randomized longitudinal experimental study. The animals were divided into three groups - Control: cafeteria diet (CD); Extract: CD + leaf extract (250 mg kg -1 ); and Mangiferin: CD + mangiferin (40 mg kg -1 ). Body weight and food intake were measured every week. On day eight, mRNA and protein expression of inflammatory markers were evaluated in the liver. Also, liver weight, SOD activity and malondialdehyde concentration were measured. Treatment for only eight days with mango leaf extract and mangiferin increased SOD activity. Mangiferin intake increased the mRNA expression of PPAR-α and HSP72. The leaf extract treatment enhanced PPAR-α mRNA expression. Mangiferin and leaf extract consumption caused a lower concentration of NFκB (p65) in nuclear extracts, and greater IL-10 mRNA and protein levels. This study highlights the potential of acute treatment with mango leaf extract and mangiferin to prevent liver inflammation caused by fat-rich diets. These results indicate a new use for a product that has low cost, is found in great amounts, and is not routinely used. |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 0 (PPAR alpha) 0 (Plant Extracts) 130068-27-8 (Interleukin-10) 4Y8F71G49Q (Malondialdehyde) |
| تواريخ الأحداث: | Date Created: 20190724 Date Completed: 20200115 Latest Revision: 20200115 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1039/c9fo00651f |
| PMID: | 31334539 |
| قاعدة البيانات: | MEDLINE |
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