دورية أكاديمية
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Experimental and Clinical Pharmacokinetics of Fluoxetine and Amitriptyline: Comparative Analysis and Possible Methods of Extrapolation.

التفاصيل البيبلوغرافية
العنوان: Experimental and Clinical Pharmacokinetics of Fluoxetine and Amitriptyline: Comparative Analysis and Possible Methods of Extrapolation.
المؤلفون: Kondratenko SN; Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, Moskva, Russia. snko@mail.ru., Savelyeva MI; Department of Clinical Pharmacology and Therapy, Russian Medical Academy for Continuous Professional Education, Ministry of Health of the Russian Federation, Moscow, Russia., Kukes VG; Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, Moskva, Russia., Shikh EV; Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, Moskva, Russia., Gneushev ET; Laboratory of Drug Toxicology, National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
المصدر: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2019 Jul; Vol. 167 (3), pp. 356-362. Date of Electronic Publication: 2019 Jul 26.
نوع المنشور: Comparative Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Springer
Original Publication: New York, Consultants Bureau.
مواضيع طبية MeSH: Amitriptyline/*pharmacokinetics , Fluoxetine/*pharmacokinetics , Nortriptyline/*blood, Administration, Oral ; Amitriptyline/administration & dosage ; Amitriptyline/blood ; Animals ; Biological Availability ; Dogs ; Female ; Fluoxetine/administration & dosage ; Fluoxetine/blood ; Humans ; Male
مستخلص: The pharmacokinetics of two fluoxetine capsulated dosage forms and two amitriptyline tablet forms after a single oral intake was studied in dogs and healthy volunteers. High significant correlations were detected between plasma concentrations of fluoxetine (r=0.96, p<0.00001, n=11) and amitriptyline (r=0.78, p<0.0224, n=8) in dogs and volunteers. A correlation of medium strength (though insignificant) was detected between nortriptyline concentrations in the plasma of dogs and volunteers (r=0.69, p<0.199, n=5). The bioavailability parameters of the test drugs in dogs and volunteers did not differ. Similar trends of fluoxetine and amitriptyline pharmacokinetic parameters were revealed in volunteers and animals. Methods for extrapolation of experimental pharmacokinetics parameters of fluoxetine and amitriptyline obtained on dogs for humans are proposed and validated.
فهرسة مساهمة: Keywords: amitriptyline; extrapolation; fluoxetine; nortriptyline; pharmacokinetics
المشرفين على المادة: 01K63SUP8D (Fluoxetine)
1806D8D52K (Amitriptyline)
BL03SY4LXB (Nortriptyline)
تواريخ الأحداث: Date Created: 20190727 Date Completed: 20200101 Latest Revision: 20200101
رمز التحديث: 20231215
DOI: 10.1007/s10517-019-04526-9
PMID: 31346879
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-8221
DOI:10.1007/s10517-019-04526-9