دورية أكاديمية
أعرض في EDS

Innate lymphoid cells link gut microbes with mucosal T cell immunity.

التفاصيل البيبلوغرافية
العنوان: Innate lymphoid cells link gut microbes with mucosal T cell immunity.
المؤلفون: Castellanos JG; Jill Roberts Institute for Research in IBD, Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, USA., Longman RS; Jill Roberts Institute for Research in IBD, Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, USA.
المصدر: Gut microbes [Gut Microbes] 2020; Vol. 11 (2), pp. 231-236. Date of Electronic Publication: 2019 Jul 26.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015- : Philadelphia, PA : Taylor & Francis
Original Publication: Austin, Tex. : Landes Bioscience
مواضيع طبية MeSH: Immunity, Mucosal*, Gastrointestinal Microbiome/*immunology , Intestinal Mucosa/*immunology , Intraepithelial Lymphocytes/*immunology, Animals ; Antimicrobial Cationic Peptides/metabolism ; Colitis/metabolism ; Colitis/microbiology ; Cytokines/metabolism ; Humans ; Immunity, Innate/immunology ; Inflammatory Bowel Diseases/metabolism ; Inflammatory Bowel Diseases/microbiology ; Intestinal Mucosa/cytology ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/microbiology ; OX40 Ligand/metabolism ; Tumor Necrosis Factor Ligand Superfamily Member 15/metabolism
مستخلص: Despite continuous exposure to trillions of microbes, the intestinal immune system protects the mucosa by balancing barrier protection, tolerance, and immunity. As both sentinel and effector, the mucosal innate immune system plays a central role in coordinating these responses. By integrating signals from the intestinal microbiota, mononuclear phagocytes (MNPs) serve as a critical link in regulating effector functions of group 3 innate lymphoid cells (ILC3s). Our recent work identified the role for MNP production of the IBD-linked protein TNF-like ligand 1A (TL1A) in modulating microbial regulation of ILC3 barrier immunity. These findings highlight a broader role for ILC3s in local control of T cell immunity and their potential role in the pathogenesis and treatment of inflammatory disease.
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معلومات مُعتمدة: R01 DK114252 United States DK NIDDK NIH HHS; R01 DK120985 United States DK NIDDK NIH HHS; R03 DK111852 United States DK NIDDK NIH HHS; T32 GM007739 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: Innate lymphoid cells; OX40L; TL1A; inflammatory bowel diseases
المشرفين على المادة: 0 (Antimicrobial Cationic Peptides)
0 (Cytokines)
0 (OX40 Ligand)
0 (TNFSF15 protein, human)
0 (Tumor Necrosis Factor Ligand Superfamily Member 15)
تواريخ الأحداث: Date Created: 20190727 Date Completed: 20200929 Latest Revision: 20210428
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7053954
DOI: 10.1080/19490976.2019.1638725
PMID: 31347946
قاعدة البيانات: MEDLINE
الوصف
تدمد:1949-0984
DOI:10.1080/19490976.2019.1638725