دورية أكاديمية
أعرض في EDS

The Role of Vitamin A in Wound Healing.

التفاصيل البيبلوغرافية
العنوان: The Role of Vitamin A in Wound Healing.
المؤلفون: Polcz ME; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Barbul A; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; The Tennessee Valley Nashville VA Medical Center, Nashville, Tennessee, USA.
المصدر: Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition [Nutr Clin Pract] 2019 Oct; Vol. 34 (5), pp. 695-700. Date of Electronic Publication: 2019 Aug 07.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 8606733 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-2452 (Electronic) Linking ISSN: 08845336 NLM ISO Abbreviation: Nutr Clin Pract Subsets: MEDLINE
أسماء مطبوعة: Publication: 2018- : [Hoboken, NJ] : Wiley
Original Publication: [Baltimore, Md. : Williams & Wilkins, c1986-
مواضيع طبية MeSH: Retinoids/*pharmacology , Vitamin A/*pharmacology , Wound Healing/*drug effects, Humans ; Receptors, Retinoic Acid/metabolism ; Retinol-Binding Proteins/metabolism
مستخلص: Vitamin A is an essential micronutrient that comes in multiple forms, including retinols, retinals, and retinoic acids. Dietary vitamin A is absorbed as retinol from preformed retinoids or as pro-vitamin A carotenoids that are converted into retinol in the enterocyte. These are then delivered to the liver for storage via chylomicrons and later released into the circulation and to its biologically active tissues bound to retinol-binding protein. Vitamin A is a crucial component of many important and diverse biological functions, including reproduction, embryological development, cellular differentiation, growth, immunity, and vision. Vitamin A functions mostly through nuclear retinoic acid receptors, retinoid X receptors, and peroxisome proliferator-activated receptors. Retinoids regulate the growth and differentiation of many cell types within skin, and its deficiency leads to abnormal epithelial keratinization. In wounded tissue, vitamin A stimulates epidermal turnover, increases the rate of re-epithelialization, and restores epithelial structure. Retinoids have the unique ability to reverse the inhibitory effects of anti-inflammatory steroids on wound healing. In addition to its role in the inflammatory phase of wound healing, retinoic acid has been demonstrated to enhance production of extracellular matrix components such as collagen type I and fibronectin, increase proliferation of keratinocytes and fibroblasts, and decrease levels of degrading matrix metalloproteinases.
(© 2019 American Society for Parenteral and Enteral Nutrition.)
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فهرسة مساهمة: Keywords: inflammation; retinoids; skin; vitamin A; wound healing
المشرفين على المادة: 0 (Receptors, Retinoic Acid)
0 (Retinoids)
0 (Retinol-Binding Proteins)
11103-57-4 (Vitamin A)
تواريخ الأحداث: Date Created: 20190808 Date Completed: 20200303 Latest Revision: 20200303
رمز التحديث: 20231215
DOI: 10.1002/ncp.10376
PMID: 31389093
قاعدة البيانات: MEDLINE
الوصف
تدمد:1941-2452
DOI:10.1002/ncp.10376