دورية أكاديمية
أعرض في EDS

Effectiveness of Combined External Ventricular Drainage with Intraventricular Fibrinolysis for the Treatment of Intraventricular Haemorrhage with Acute Obstructive Hydrocephalus.

التفاصيل البيبلوغرافية
العنوان: Effectiveness of Combined External Ventricular Drainage with Intraventricular Fibrinolysis for the Treatment of Intraventricular Haemorrhage with Acute Obstructive Hydrocephalus.
المؤلفون: Luong CQ; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam, chinhlq@bachmai.edu.vn.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam, chinhlq@bachmai.edu.vn., Nguyen AD; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam., Nguyen CV; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam., Mai TD; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam., Nguyen TA; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam., Do SN; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam., Dao PV; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam., Pham HTM; Epidemiology Department, Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam., Pham DT; Department of Science Management, Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam., Ngo HM; Department of Neurosurgery II, Viet Duc Hospital, Hanoi, Vietnam., Nguyen QH; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam., Nguyen DT; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam., Tran TH; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam., Le KV; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam., Do NT; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam., Ngo ND; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam., Nguyen VD; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam., Ngo HD; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam., Hoang HB; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam.; Emergency and Critical Care Department, Hanoi Medical University Hospital, Hanoi, Vietnam., Vu HV; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam.; Emergency and Critical Care Department, Hanoi Medical University Hospital, Hanoi, Vietnam., Vu LT; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam., Ngo BT; Undergraduate Training and Management Department, Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam., Nguyen BX; Department of Postgraduate Management, Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam., Khuong DQ; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam., Nguyen DT; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam., Vuong TX; Emergency Department, Bach Mai Hospital, Hanoi, Vietnam., Be TH; Poison Control Centre, Bach Mai Hospital, Hanoi, Vietnam., Gaberel T; Department of Neurosurgery, Caen University Hospital, Caen, France.; Department of Neurosurgery, University of Caen Normandy, Caen, France., Nguyen LV; Department of Neurology, Bach Mai Hospital, Hanoi, Vietnam.; Department of Neurology, Hanoi Medical University, Hanoi, Vietnam.
المصدر: Cerebrovascular diseases extra [Cerebrovasc Dis Extra] 2019; Vol. 9 (2), pp. 77-89. Date of Electronic Publication: 2019 Aug 13.
نوع المنشور: Journal Article; Observational Study
اللغة: English
بيانات الدورية: Publisher: Karger Country of Publication: Switzerland NLM ID: 101577885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1664-5456 (Electronic) Linking ISSN: 16645456 NLM ISO Abbreviation: Cerebrovasc Dis Extra Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : Karger, 2011-
مواضيع طبية MeSH: Cerebral Intraventricular Hemorrhage/*therapy , Drainage/*methods , Fibrinolytic Agents/*administration & dosage , Hydrocephalus/*therapy , Thrombolytic Therapy/*methods , Tissue Plasminogen Activator/*administration & dosage, Acute Disease ; Adult ; Aged ; Cerebral Intraventricular Hemorrhage/diagnostic imaging ; Cerebral Intraventricular Hemorrhage/mortality ; Cerebral Intraventricular Hemorrhage/physiopathology ; Combined Modality Therapy ; Drainage/adverse effects ; Drainage/mortality ; Female ; Fibrinolytic Agents/adverse effects ; Humans ; Hydrocephalus/diagnostic imaging ; Hydrocephalus/mortality ; Hydrocephalus/physiopathology ; Male ; Middle Aged ; Prospective Studies ; Recovery of Function ; Risk Assessment ; Risk Factors ; Thrombolytic Therapy/adverse effects ; Thrombolytic Therapy/mortality ; Time Factors ; Tissue Plasminogen Activator/adverse effects ; Treatment Outcome
مستخلص: Background: Intraventricular haemorrhage (IVH) patients with acute obstructive hydrocephalus (AOH) who require external ventricular drainage (EVD) are at high risk for poor outcomes. Intraventricular fibrinolysis (IVF) with low-dose recombinant tissue plasminogen activator (rtPA) can be used to improve patient outcomes. Here, we evaluated the impact of IVF on the risk of death and the functional outcomes in IVH patients with AOH.
Methods: This prospective cohort study included IVH patients with hypertensive intracranial haemorrhage complicated by AOH who required EVD. We evaluated the risk of death and the functional outcomes at 1 and 3 months, with a specific focus on the impact of combined EVD with IVF by low-dose rtPA.
Results: Between November 30, 2011 and December 30, 2014, 80 patients were included. Forty-five patients were treated with EVD alone (EVD group) and 35 received IVF (EVD+IVF group). The 30- and 90-day mortality rates were lower in the EVD+IVF group than in the EVD group (42.2 vs. 11.4%, p = 0.003, and 62.2 vs. 20%, p < 0.001, respectively). The Graeb scores were significantly lower in the EVD+IVF group than in the EVD group (p ≤ 0.001) during the first 3 days and on day 7 after assignment. The 30-day good functional outcome (modified Rankin Scale [mRS] score 0-3) was also higher in the EVD+IVF group than in the EVD group (6.7 vs. 28.6%, p = 0.008). However, the 90-day good functional outcome (mRS score 0-3) did not significantly increase in the EVD+IVF group (30.8% in the EVD group vs. 51.6% in the EVD+IVF group, p = 0.112).
Conclusions: In our prospective observational study, EVD+IVF was associated with a lower risk of death in IVH patients. EVD+IVF improved the chance of having a good functional outcome at 1 month; however, this result was no longer observed at 3 months.
(© 2019 The Author(s) Published by S. Karger AG, Basel.)
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فهرسة مساهمة: Keywords: Acute obstructive hydrocephalus; External ventricular drainage; Intracerebral haemorrhage; Intraventricular fibrinolysis; Intraventricular haemorrhage; Recombinant tissue plasminogen activator
المشرفين على المادة: 0 (Fibrinolytic Agents)
EC 3.4.21.68 (Tissue Plasminogen Activator)
تواريخ الأحداث: Date Created: 20190814 Date Completed: 20200211 Latest Revision: 20200309
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6751468
DOI: 10.1159/000501530
PMID: 31408859
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-5456
DOI:10.1159/000501530