دورية أكاديمية
أعرض في EDS

Higher vitamin D levels in Nigerian albinos compared with pigmented controls.

التفاصيل البيبلوغرافية
العنوان: Higher vitamin D levels in Nigerian albinos compared with pigmented controls.
المؤلفون: Enechukwu N; Department of Internal Medicine, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Cockburn M; Department of Epidemiology, University of Colorado School of Public Health, Aurora, CO, USA., Ogun G; Department of Pathology, University College Hospital, Ibadan, Oyo State, Nigeria., Ezejiofor OI; Department of Internal Medicine, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., George A; Department of Medicine, University College Hospital, Ibadan, Oyo State, Nigeria., Ogunbiyi A; Department of Medicine, University College Hospital, Ibadan, Oyo State, Nigeria.
المصدر: International journal of dermatology [Int J Dermatol] 2019 Oct; Vol. 58 (10), pp. 1148-1152. Date of Electronic Publication: 2019 Aug 16.
نوع المنشور: Comparative Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Science Country of Publication: England NLM ID: 0243704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-4632 (Electronic) Linking ISSN: 00119059 NLM ISO Abbreviation: Int J Dermatol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Blackwell Science
Original Publication: Philadelphia, Lippincott.
مواضيع طبية MeSH: Skin Pigmentation*, Albinism/*blood , Skin/*metabolism , Vitamin D/*blood, Adult ; Cross-Sectional Studies ; Female ; Humans ; Male ; Nigeria ; Protective Clothing ; Skin/radiation effects ; Sunlight/adverse effects ; Sunscreening Agents/administration & dosage ; Tropical Climate ; Vitamin D/metabolism ; Young Adult
مستخلص: Background: Several studies have suggested that the lower vitamin D levels in blacks is attributable to the effect of increased pigmentation in blocking cutaneous ultraviolet (UV)-mediated production of vitamin D. Albinos are devoid of melanin and should invariably have higher vitamin D levels when compared with their pigmented counterparts. However, strict photoprotection required in their medical management has been shown to reduce UV-dependent vitamin D production. Associations between low vitamin D and several diseases suggest that the pattern of vitamin D in the black African albino be investigated.
Objective: To compare the vitamin D levels between albinos and normal pigmented controls in Anambra State, Nigeria, and thus highlight the impact of skin pigmentation and sun protection practices on vitamin D levels.
Methodology: This was a cross-sectional study of a consecutive series of albinos from the Albino Foundation, Anambra State. The vitamin D levels of 61 albinos and 58 matched pigmented controls were analyzed. The sun exposures of the participants were calculated using validated sun exposure questionnaires.
Results: The albinos had significantly higher vitamin D levels (median 95.9 [50.1-177.4] ng/ml) than the controls (78.2 [12.1-250] ng/ml). None of the albinos had low vitamin D levels. None of the sun protection practices had significant effects on vitamin D levels.
Conclusion: This study contests the claim that black Africans including albinos have low vitamin D levels. Albinos living in South East Nigeria have significantly higher vitamin D levels than their pigmented counterparts.
(© 2019 The International Society of Dermatology.)
References: Deluca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 2004; 80: 1689S-1696S.
Chun RF, Liu PT, Modlin RL, et al. Impact of vitamin D on immune function: lessons learned from genome-wide analysis. Front Physiol 2014; 5: 97.
Wӧbke TK, SorgBL, Steinhilber D. Vitamin D in inflammatory diseases. Front Physiol 2014; 5: 138. Available from: doi: https://doi.org/10.3389/fphys.2014.00244.
Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol 2009; 19: 73-78.
Kaidbey KH, Agin PP, Sayre RM, et al. Photoprotection by melanin: a comparison of Black and Caucasian skin. J Am Acad Dermatol 1979; 1: 249-260.
Matsoka LY, Wortsman J, Chen TC, et al. Compensation for the interracial variance in the cutaneous synthesis of vitamin D. J Lab Clin Med 1995; 126: 452-457.
Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357: 266-281.
Humayun Q, Iqbal R, Azam I, et al. Development and validation of sunlight exposure measurement questionnaire (SEM-Q) for use in adult population residing in Pakistan. BMC Public Health 2012; 12: 1.
Davis S, Capjack L, Kerr N, et al. Clothing as protection from ultraviolet radiation: which fabric is effective? Int J Dermatol 1997; 36: 374-379.
Fitzpatrick Skin Type. Australian Radiation Protection and Nuclear Safety Agency. Available at: http://www.arpansa.gov.au/pubs/RadiationProtection/FitzpatrickSkinType.pdf. [Accessed 20th September 2016].
Taylor C, Lamparello B, Kruczek K, et al. Validation of a food frequency questionnaire for determining Calcium and vitamin D intake by adolescent girls with Anorexia Nervosa. J Am Diet Assoc 2009; 109: 479-85.
Cornish DA, Maluleke V, Mhlanga T. An investigation into a possible relationship between vitamin D, Parathyroid hormone, Calcium and Magnesium in a normally pigmented and an albino rural Black population in the Northern Province of South Africa. BioFactors 2000; 11: 35-38.
Van der Walt JE, Sinclair W. Vitamin D levels in patients with Albinism compared with those in normally pigmented Black patients attending dermatology clinics in the Free State province, South Africa. Int J Dermatol 2016; 55: 1014-1019.
Bogaczewicz J, Karczmarewicz E, Pludowski P, et al. Requirement for vitamin D supplementation in patients using photoprotection: variations in vitamin D levels and bone formation markers. Int J Dermatol 2016; 55: e176-e183.
Looker AC, Pfeiffer CM, Lacher DA, et al. Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004. Am J Clin Nutr 2008; 88: 1519-1527.
Mallah EM, Hamad MF, ElManaseer MA, et al. Plasma concentrations of 25-hydroxyvitamin D among Jordanians: effect of biological and habitual factors on vitamin D status. BMC Clin Pathol 2011; 11: 1.
Lagunova Z, Porojnicu AC, Lindberg F, et al. The dependency of vitamin D status on body mass index, Gender, Age and Season. Anticancer Res 2009; 29: 3713-3720.
المشرفين على المادة: 0 (Sunscreening Agents)
1406-16-2 (Vitamin D)
تواريخ الأحداث: Date Created: 20190817 Date Completed: 20200203 Latest Revision: 20200203
رمز التحديث: 20231215
DOI: 10.1111/ijd.14611
PMID: 31418463
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-4632
DOI:10.1111/ijd.14611