دورية أكاديمية

Approaches for measuring the dynamics of RNA-protein interactions.

التفاصيل البيبلوغرافية
العنوان: Approaches for measuring the dynamics of RNA-protein interactions.
المؤلفون: Licatalosi DD; Center for RNA Science and Therapeutics, School of Medicine, Case Western Reserve University, Cleveland, Ohio., Ye X; Center for RNA Science and Therapeutics, School of Medicine, Case Western Reserve University, Cleveland, Ohio., Jankowsky E; Center for RNA Science and Therapeutics, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
المصدر: Wiley interdisciplinary reviews. RNA [Wiley Interdiscip Rev RNA] 2020 Jan; Vol. 11 (1), pp. e1565. Date of Electronic Publication: 2019 Aug 20.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101536955 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-7012 (Electronic) Linking ISSN: 17577004 NLM ISO Abbreviation: Wiley Interdiscip Rev RNA Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hoboken, NJ : Wiley, 2010-
مواضيع طبية MeSH: RNA/*metabolism , RNA-Binding Proteins/*metabolism, Animals ; Humans ; Kinetics ; RNA/genetics ; RNA-Binding Proteins/genetics
مستخلص: RNA-protein interactions are pivotal for the regulation of gene expression from bacteria to human. RNA-protein interactions are dynamic; they change over biologically relevant timescales. Understanding the regulation of gene expression at the RNA level therefore requires knowledge of the dynamics of RNA-protein interactions. Here, we discuss the main experimental approaches to measure dynamic aspects of RNA-protein interactions. We cover techniques that assess dynamics of cellular RNA-protein interactions that accompany biological processes over timescales of hours or longer and techniques measuring the kinetic dynamics of RNA-protein interactions in vitro. This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications RNA Interactions with Proteins and Other Molecules > Protein-RNA Recognition RNA Interactions with Proteins and Other Molecules > RNA-Protein Complexes RNA Evolution and Genomics > Ribonomics.
(© 2019 Wiley Periodicals, Inc.)
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معلومات مُعتمدة: R01 GM107331 United States GM NIGMS NIH HHS; R35 GM118088 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: CLIP; FRET; RNA binding protein; enzyme; kinetics
المشرفين على المادة: 0 (RNA-Binding Proteins)
63231-63-0 (RNA)
تواريخ الأحداث: Date Created: 20190821 Date Completed: 20210101 Latest Revision: 20240328
رمز التحديث: 20240329
مُعرف محوري في PubMed: PMC7006490
DOI: 10.1002/wrna.1565
PMID: 31429211
قاعدة البيانات: MEDLINE
الوصف
تدمد:1757-7012
DOI:10.1002/wrna.1565