دورية أكاديمية
أعرض في EDS

Diagnostic performance of multiparametric MRI in the evaluation of treatment response in glioma patients at 3T.

التفاصيل البيبلوغرافية
العنوان: Diagnostic performance of multiparametric MRI in the evaluation of treatment response in glioma patients at 3T.
المؤلفون: Liu J; Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China., Li C; Department of Neurosurgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China., Chen Y; Department of Neurosurgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China., Lv X; Department of Medical Imaging, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China., Lv Y; Department of Medical Imaging, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China., Zhou J; Department of Medical Imaging, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China., Xi S; Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China., Dou W; GE Healthcare, Beijing, China., Qian L; GE Healthcare, Beijing, China., Zheng H; Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China., Wu Y; Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China., Chen Z; Department of Neurosurgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China.
المصدر: Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2020 Apr; Vol. 51 (4), pp. 1154-1161. Date of Electronic Publication: 2019 Aug 20.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 9105850 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-2586 (Electronic) Linking ISSN: 10531807 NLM ISO Abbreviation: J Magn Reson Imaging Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005-> : Hoboken , N.J. : Wiley-Liss
Original Publication: Chicago, IL : Society for Magnetic Resonance Imaging, c1991-
مواضيع طبية MeSH: Brain Neoplasms*/diagnostic imaging , Brain Neoplasms*/therapy , Glioma*/diagnostic imaging , Glioma*/therapy , Multiparametric Magnetic Resonance Imaging*, Diffusion Magnetic Resonance Imaging ; Humans ; Magnetic Resonance Imaging ; Neoplasm Recurrence, Local ; Prospective Studies
مستخلص: Background: MRI is one of the most important techniques to assess the treatment response of gliomas. However, differentiating tumor recurrence (TuR) from treatment effects (TrE) remains challenging.
Purpose: To compare the diagnostic performance of MR diffusion-weighted imaging (DWI), arterial spin labeling (ASL), proton MR spectroscopy (MRS), and amide proton transfer (APT) imaging in differentiating between TuR and TrE in posttreatment glioma patients.
Study Type: Prospective.
Population: Thirty patients with suspected tumor progression.
Field Strength/sequence: DWI, ASL, proton MRS, and APT imaging were performed at 3T MR.
Assessment: MR indices, including ADC, relative cerebral blood flow (rCBF), ratios of Cho/Cr, Cho/NAA, and NAA/Cr and APT-weighted (APTw) effect were obtained from DWI, ASL, proton MRS, and APT imaging, respectively. Indices were measured in the contralateral normal-appearing white matter and lesions defined on the Gd-enhanced T 1 w image. TuR or TrE was either determined histologically or clinically from longitudinal MRI follow-up for at least 6 months.
Statistical Tests: The diagnostic performance of the indices was evaluated using Student's t-test, receiver operating characteristic (ROC) curve, and multivariate logistic regression analyses.
Results: Among the 30 patients, 16 were diagnosed as having TuR and the rest having TrE. The recurrent tumors showed a significantly higher APTw effect (1.56 ± 1.14%) and rCBF (1.44 ± 0.61) compared with lesions representing treatment effects (-0.44 ± 1.34% and 0.72 ± 0.25, respectively, with P < 0.001). The areas under the curve (AUCs) were 0.87 and 0.90 for APTw and rCBF, respectively, in differentiating between TuR and TrE. Combining APTw and rCBF achieved a higher AUC of 0.93. MRS index ratios of Cho/Cr (P = 0.25), Cho/NAA (P = 0.16), and NAA/Cr (P = 0.86) and ADC (P = 0.37) showed no significant differences between TuR and TrE lesions, with AUCs lower than 0.70.
Data Conclusion: Compared with DWI and MRS, ASL and APT imaging techniques showed better diagnostic capability in distinguishing TuR from TrE.
Level of Evidence: 1 Technical Efficacy: Stage 4 J. Magn. Reson. Imaging 2020;51:1154-1161.
(© 2019 International Society for Magnetic Resonance in Medicine.)
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فهرسة مساهمة: Keywords: amide proton transfer imaging; diagnostic performance; glioma; magnetic resonance imaging; treatment effects; tumor recurrence
تواريخ الأحداث: Date Created: 20190821 Date Completed: 20210519 Latest Revision: 20210519
رمز التحديث: 20231215
DOI: 10.1002/jmri.26900
PMID: 31430008
قاعدة البيانات: MEDLINE
الوصف
تدمد:1522-2586
DOI:10.1002/jmri.26900