دورية أكاديمية
أعرض في EDS

Early glottic cancer in a veteran population: Impact of race on management and outcomes.

التفاصيل البيبلوغرافية
العنوان: Early glottic cancer in a veteran population: Impact of race on management and outcomes.
المؤلفون: Fullmer TM; Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, U.S.A., Shi J; Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, U.S.A., Skinner HD; Department of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Hernandez DJ; Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, U.S.A.; ENT Section, Operative Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, U.S.A., Huang AT; Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, U.S.A.; ENT Section, Operative Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, U.S.A., Mai W; Department of Radiation Oncology, Baylor College of Medicine, Houston, Texas, U.S.A., Parke RB; Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, U.S.A.; ENT Section, Operative Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, U.S.A., Donovan DT; Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, U.S.A.; ENT Section, Operative Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, U.S.A., Sandulache VC; Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, U.S.A.; ENT Section, Operative Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, U.S.A.
المصدر: The Laryngoscope [Laryngoscope] 2020 Jul; Vol. 130 (7), pp. 1733-1739. Date of Electronic Publication: 2019 Aug 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 8607378 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-4995 (Electronic) Linking ISSN: 0023852X NLM ISO Abbreviation: Laryngoscope Subsets: MEDLINE
أسماء مطبوعة: Publication: <2009- >: Philadelphia, PA : Wiley-Blackwell
Original Publication: St. Louis, Mo. : [s.n., 1896-
مواضيع طبية MeSH: Disease Management* , Neoplasm Staging*, Carcinoma, Squamous Cell/*diagnosis , Laryngeal Neoplasms/*diagnosis , Risk Assessment/*methods , Veterans/*statistics & numerical data, Aged ; Carcinoma, Squamous Cell/epidemiology ; Carcinoma, Squamous Cell/therapy ; Combined Modality Therapy/methods ; Disease-Free Survival ; Female ; Glottis ; Humans ; Laryngeal Neoplasms/epidemiology ; Laryngeal Neoplasms/therapy ; Male ; Middle Aged ; Morbidity/trends ; Prognosis ; Retrospective Studies ; Risk Factors ; Survival Rate/trends ; United States/epidemiology
مستخلص: Objectives: Multiple population studies have shown racial discrepancies in head and neck cancer treatment and outcomes. We sought to characterize the impact of race on clinical outcomes for patients with early glottic squamous cell carcinoma (SCC) in a tertiary institution which provides equivalent access to care.
Methods: We retrospectively reviewed all early glottic (T1-T2) squamous cell carcinoma at a single institution, the Michael E. DeBakey Veterans' Administration Medical Center (MEDVAMC). Data collected included demographic information, primary and adjuvant treatment modalities, time to diagnosis, time to treatment, recurrences, recurrence treatment modality, secondary malignancies, recurrence-free survival (RFS), and overall survival (OS).
Results: One hundred seventeen patients with a primary diagnosis of T1-T2 glottic squamous cell carcinoma were included. Black and white patients demonstrated equivalent rates of recurrence, RFS, and OS. There was no significant difference in treatment delivery by race for all recorded parameters. T1b tumors were associated with an increased risk of recurrence which did not translate into a statistically significant decrease in RFS or OS. Surgical treatment was associated with increased recurrence but similar RFS and OS compared to radiation-based treatment. Secondary malignancies were common; 12% of patients were diagnosed with a second primary lung cancer during the study period.
Conclusion: At our institution, race did not impact survival when access to care, treatment selection, and delivery are equivalent for early glottic SCC. Secondary lung cancer is a critical risk factor for mortality in this patient group and requires long-term surveillance and monitoring.
Level of Evidence: 4 Laryngoscope, 130:1733-1739, 2020.
(© 2019 The American Laryngological, Rhinological and Otological Society, Inc.)
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فهرسة مساهمة: Keywords: Glottic cancer; Veteran; radiation; smoking
تواريخ الأحداث: Date Created: 20190829 Date Completed: 20201020 Latest Revision: 20201020
رمز التحديث: 20221213
DOI: 10.1002/lary.28262
PMID: 31461171
قاعدة البيانات: MEDLINE
الوصف
تدمد:1531-4995
DOI:10.1002/lary.28262