دورية أكاديمية
LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor) Regulates Cardiac L-Type Calcium Channels by Modulating NEDD (Neural Precursor Cell Expressed Developmentally Downregulated Protein) 4-1 Ubiquitin Ligase.
| العنوان: | LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor) Regulates Cardiac L-Type Calcium Channels by Modulating NEDD (Neural Precursor Cell Expressed Developmentally Downregulated Protein) 4-1 Ubiquitin Ligase. |
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| المؤلفون: | Moshal KS; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence (K.S.M., K.R., A.Y.K., N.N.T., A.X., T.Y.K., Y.L., W.L., D.T., B.-R.C., G.K.)., Roder K; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence (K.S.M., K.R., A.Y.K., N.N.T., A.X., T.Y.K., Y.L., W.L., D.T., B.-R.C., G.K.)., Kabakov AY; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence (K.S.M., K.R., A.Y.K., N.N.T., A.X., T.Y.K., Y.L., W.L., D.T., B.-R.C., G.K.)., Werdich AA; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (A.A.W., D.Y.-E.C., C.A.M.)., Chiang DY; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (A.A.W., D.Y.-E.C., C.A.M.)., Turan NN; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence (K.S.M., K.R., A.Y.K., N.N.T., A.X., T.Y.K., Y.L., W.L., D.T., B.-R.C., G.K.)., Xie A; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence (K.S.M., K.R., A.Y.K., N.N.T., A.X., T.Y.K., Y.L., W.L., D.T., B.-R.C., G.K.)., Kim TY; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence (K.S.M., K.R., A.Y.K., N.N.T., A.X., T.Y.K., Y.L., W.L., D.T., B.-R.C., G.K.)., Cooper LL; Biology Department, Vassar College, Poughkeepsie, NY (L.L.C)., Lu Y; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence (K.S.M., K.R., A.Y.K., N.N.T., A.X., T.Y.K., Y.L., W.L., D.T., B.-R.C., G.K.)., Zhong M; Physics Department and Center for Interdisciplinary Research in Complex Systems, Northeastern University, Boston, MA (M.Z., A.K.)., Li W; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence (K.S.M., K.R., A.Y.K., N.N.T., A.X., T.Y.K., Y.L., W.L., D.T., B.-R.C., G.K.)., Terentyev D; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence (K.S.M., K.R., A.Y.K., N.N.T., A.X., T.Y.K., Y.L., W.L., D.T., B.-R.C., G.K.)., Choi BR; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence (K.S.M., K.R., A.Y.K., N.N.T., A.X., T.Y.K., Y.L., W.L., D.T., B.-R.C., G.K.)., Karma A; Physics Department and Center for Interdisciplinary Research in Complex Systems, Northeastern University, Boston, MA (M.Z., A.K.)., MacRae CA; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (A.A.W., D.Y.-E.C., C.A.M.)., Koren G; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence (K.S.M., K.R., A.Y.K., N.N.T., A.X., T.Y.K., Y.L., W.L., D.T., B.-R.C., G.K.). |
| المصدر: | Circulation. Genomic and precision medicine [Circ Genom Precis Med] 2019 Sep; Vol. 12 (9), pp. 407-420. Date of Electronic Publication: 2019 Aug 28. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101714113 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2574-8300 (Electronic) Linking ISSN: 25748300 NLM ISO Abbreviation: Circ Genom Precis Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Baltimore, MD] : Lippincott Williams & Wilkins, [2018]- |
| مواضيع طبية MeSH: | Calcium Channels, L-Type/*metabolism , DNA-Binding Proteins/*metabolism , Membrane Proteins/*metabolism , Nedd4 Ubiquitin Protein Ligases/*metabolism , Zebrafish/*metabolism , Zebrafish Proteins/*metabolism, Animals ; Calcium/metabolism ; Calcium Channels, L-Type/genetics ; DNA-Binding Proteins/genetics ; Heart/embryology ; Humans ; Membrane Proteins/genetics ; Myocytes, Cardiac/enzymology ; Nedd4 Ubiquitin Protein Ligases/genetics ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Rabbits ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Ubiquitination ; Zebrafish/genetics ; Zebrafish/growth & development ; Zebrafish Proteins/genetics |
| مستخلص: | Background: The turnover of cardiac ion channels underlying action potential duration is regulated by ubiquitination. Genome-wide association studies of QT interval identified several single-nucleotide polymorphisms located in or near genes involved in protein ubiquitination. A genetic variant upstream of LITAF (lipopolysaccharide-induced tumor necrosis factor) gene prompted us to determine its role in modulating cardiac excitation. Methods: Optical mapping was performed in zebrafish hearts to determine Ca 2+ transients. Live-cell confocal calcium imaging was performed on adult rabbit cardiomyocytes to determine intracellular Ca 2+ handling. L-type calcium channel (LTCC) current ( I Results: LITAF knockdown in zebrafish resulted in a robust increase in calcium transients. Overexpressed LITAF in 3-week-old rabbit cardiomyocytes resulted in a decrease in I Conclusions: LITAF acts as an adaptor protein promoting NEDD4-1-mediated ubiquitination and subsequent degradation of LTCC, thereby controlling LTCC membrane levels and function and thus cardiac excitation. |
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| معلومات مُعتمدة: | R01 HL096669 United States HL NHLBI NIH HHS; R01 HL121796 United States HL NHLBI NIH HHS; R00 HL112724 United States HL NHLBI NIH HHS; T32 HL094300 United States HL NHLBI NIH HHS; R01 HL134706 United States HL NHLBI NIH HHS; R01 HL110791 United States HL NHLBI NIH HHS; R01 HL142588 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: action potential; calcium; rabbit; tumor necrosis factor; ubiquitination |
| المشرفين على المادة: | 0 (Calcium Channels, L-Type) 0 (DNA-Binding Proteins) 0 (LITAF protein, human) 0 (Membrane Proteins) 0 (Nuclear Proteins) 0 (Transcription Factors) 0 (Zebrafish Proteins) 0 (litaf protein, zebrafish) EC 2.3.2.26 (Nedd4 Ubiquitin Protein Ligases) EC 2.3.2.26 (Nedd4 protein, human) EC 2.3.2.26 (nedd4a protein, zebrafish) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 20190830 Date Completed: 20200713 Latest Revision: 20240214 |
| رمز التحديث: | 20240214 |
| مُعرف محوري في PubMed: | PMC6750970 |
| DOI: | 10.1161/CIRCGEN.119.002641 |
| PMID: | 31462068 |
| قاعدة البيانات: | MEDLINE |
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