دورية أكاديمية
أعرض في EDS

Multiple primary central nervous system lymphoma in the elderly: A case report.

التفاصيل البيبلوغرافية
العنوان: Multiple primary central nervous system lymphoma in the elderly: A case report.
المؤلفون: Chen G; Department of Neurosurgery., Xu M; Department of Rheumatology., Wang X; Department of Pathology., Gao Y; Department of Neurosurgery., He C; Department of Clinical Testing, China-Japan Union Hospital of Jilin University., Chang M; Department of Neurology, Changchun Central Hospital, Chang Chun, Ji Lin, China., Zhang J; Department of Neurosurgery.
المصدر: Medicine [Medicine (Baltimore)] 2019 Aug; Vol. 98 (35), pp. e16841.
نوع المنشور: Case Reports; Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins
مواضيع طبية MeSH: Brain Neoplasms/*diagnostic imaging , Lymphoma, Non-Hodgkin/*diagnostic imaging , Multimodal Imaging/*methods , Neoplasms, Multiple Primary/*diagnostic imaging, Brain Neoplasms/pathology ; Cerebellum/diagnostic imaging ; Cerebellum/pathology ; Diffusion Magnetic Resonance Imaging ; Fatal Outcome ; Frontal Lobe/diagnostic imaging ; Frontal Lobe/pathology ; Hippocampus/diagnostic imaging ; Hippocampus/pathology ; Humans ; Lymphoma, Non-Hodgkin/pathology ; Male ; Middle Aged ; Neoplasms, Multiple Primary/pathology ; Occipital Lobe/diagnostic imaging ; Occipital Lobe/pathology ; Positron Emission Tomography Computed Tomography
مستخلص: Rationale: Multiple primary central nervous system lymphoma (MPCNSL) is a rare disease with differential diagnosis and treatment. As the underlying pathogenesis is not yet clarified, the early-stage clinical manifestations are occult and atypical. Also, the imaging manifestations are not specific, which is challenging for the clinical diagnosis and treatment. Therefore, additional clinical research is essential to understand the etiology of the disease.
Patient Concerns: A 63-year-old male patient suffered from MPCNSLs but without typical clinical manifestations. The findings of the imaging examination were as follows. Magnetic resonance imaging (MRI) showed long T1 and T2 signal shadows in the right frontal lobe, right hippocampus, right cerebellar hemisphere, and the left occipital lobe. In addition, patchy T1-enhanced signal shadows were observed in the right frontal lobe and around the midline. Frontal lesions were detected in the magnetic resonance spectroscopy (MRS), Cho peak increased, and N-acetylaspartate (NAA) peak decreased. On the other hand, in the diffusion weighted imaging (DWI), apparent dispersion coefficient (ADC) showed low-value changes and high signal changes. The positron emission tomography-computed tomography (PET-CT) displayed radioactive accumulation in the right frontal lobe.
Diagnosis: Multiple primary central nervous system lymphoma.
Interventions: The patient received some conservative medical treatment, but his condition continued to worsen. Finally, he received a pathological biopsy, and refused further treatment after the result was reported.
Outcomes: The patient died 1 week after biopsy, and the course of disease was about 100 days.
Lessons: PCNSL is a primary intracranial malignancy with low incidence and a high degree of malignancy and specificity in clinical manifestations. To facilitate early clinical treatment and improve the long-term survival of patients, it is necessary to master the imaging diagnostic methods and its features. The comprehensive application of multiple imaging examinations, such as CT, MRI, PET/CT, and PET/MRI, as well as, cerebrospinal fluid cytology can greatly improve the diagnosis of PCNSL.
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تواريخ الأحداث: Date Created: 20190830 Date Completed: 20190925 Latest Revision: 20221005
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6736474
DOI: 10.1097/MD.0000000000016841
PMID: 31464910
قاعدة البيانات: MEDLINE
الوصف
تدمد:1536-5964
DOI:10.1097/MD.0000000000016841