دورية أكاديمية
Post-exercise Hypotension Produced by Supramaximal Interval Exercise is Potentiated by Angiotensin Receptor Blockers.
| العنوان: | Post-exercise Hypotension Produced by Supramaximal Interval Exercise is Potentiated by Angiotensin Receptor Blockers. |
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| المؤلفون: | Ramirez-Jimenez M; Exercise Physiology Lab, Universidad de Castilla-La Mancha, Toledo, Spain., Morales-Palomo F; Exercise Physiology Lab, Universidad de Castilla-La Mancha, Toledo, Spain., Ortega JF; Exercise Physiology Lab, Universidad de Castilla-La Mancha, Toledo, Spain., Mora-Rodriguez R; Exercise Physiology Lab, Universidad de Castilla-La Mancha, Toledo, Spain. |
| المصدر: | International journal of sports medicine [Int J Sports Med] 2019 Nov; Vol. 40 (12), pp. 756-761. Date of Electronic Publication: 2019 Sep 02. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Thieme Country of Publication: Germany NLM ID: 8008349 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-3964 (Electronic) Linking ISSN: 01724622 NLM ISO Abbreviation: Int J Sports Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Stuttgart : Thieme Original Publication: Stuttgart, New York, Thieme. |
| مواضيع طبية MeSH: | High-Intensity Interval Training*, Antihypertensive Agents/*therapeutic use , Hypertension/*drug therapy , Hypertension/*physiopathology , Post-Exercise Hypotension/*physiopathology, Actigraphy/methods ; Aged ; Blood Pressure/physiology ; Cross-Over Studies ; Double-Blind Method ; Female ; Fitness Trackers ; Heart Rate/physiology ; Humans ; Male ; Middle Aged ; Posture/physiology ; Time and Motion Studies |
| مستخلص: | We studied the effects of supramaximal interval exercise (SIE) with or without antihypertensive medication (AHM) on 21-hr blood pressure (BP) response. Twelve hypertensive patients chronically medicated with AHM, underwent three trials in a randomized order: a) control trial without exercise and substituting their AHM with a placebo (PLAC); b) placebo medicine and a morning bout of SIE (PLAC+SIE), and c) combining AHM and exercise (AHM+SIE). Acute and ambulatory blood pressure responses were measured for 21-hr after treatment. 20 min after treatment, systolic blood pressure (SBP) readings were reduced, similar to readings after PLAC+SIE (-9.7±6.0 mmHg, P<0.001) and AHM+SIE (-10.4±7.9 mmHg, P=0.001). 21 h after treatment, SBP remained reduced after PLAC+SIE (125±12 mmHg, P=0.022) and AHM+SIE (122±12 mmHg, P=0.013) compared to PLAC (132±16 mmHg). The BP reduction in PLAC+SIE faded out at 4 a.m., while in AHM+SIE it continued overnight. At night, BP reduction was larger in AHM+SIE than PLAC+SIE (-5.6±4.0 mmHg, P=0.006). Our data shows that a bout of supramaximal aerobic interval exercise in combination with ARB medication in the morning elicits a sustained blood pressure reduction lasting at least 21-h. Thus, the combination of exercise and angiotensin receptor blocker medication seems superior to exercise alone for acutely decreasing blood pressure. Competing Interests: All authors declare they have no conflicts of interest. (© Georg Thieme Verlag KG Stuttgart · New York.) |
| المشرفين على المادة: | 0 (Antihypertensive Agents) |
| تواريخ الأحداث: | Date Created: 20190903 Date Completed: 20191118 Latest Revision: 20191118 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1055/a-0927-6957 |
| PMID: | 31476782 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1439-3964 |
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| DOI: | 10.1055/a-0927-6957 |