دورية أكاديمية
أعرض في EDS

Preoperative vitamin D level as a post-total thyroidectomy hypocalcemia predictor: a prospective study.

التفاصيل البيبلوغرافية
العنوان: Preoperative vitamin D level as a post-total thyroidectomy hypocalcemia predictor: a prospective study.
المؤلفون: Soares CSP; Universidade Estadual Paulista (Unesp), Faculdade de Medicina de Botucatu, Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Botucatu, SP, Brazil., Tagliarini JV; Universidade Estadual Paulista (Unesp), Faculdade de Medicina de Botucatu, Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Botucatu, SP, Brazil., Mazeto GMFS; Universidade Estadual Paulista (Unesp), Faculdade de Medicina de Botucatu, Departamento de Medicina Interna, Botucatu, SP, Brazil. Electronic address: g.mazeto@unesp.br.
المصدر: Brazilian journal of otorhinolaryngology [Braz J Otorhinolaryngol] 2021 Jan-Feb; Vol. 87 (1), pp. 85-89. Date of Electronic Publication: 2019 Aug 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: E.N.T. Brazilian Society Country of Publication: Brazil NLM ID: 101207337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1808-8686 (Electronic) Linking ISSN: 18088686 NLM ISO Abbreviation: Braz J Otorhinolaryngol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: São Paulo, SP, Brasil : E.N.T. Brazilian Society
مواضيع طبية MeSH: Hypocalcemia*/diagnosis , Hypocalcemia*/etiology, Humans ; Parathyroid Hormone ; Postoperative Complications ; Prospective Studies ; Thyroidectomy/adverse effects ; Vitamin D
مستخلص: Introduction: Hypocalcemia is one of the most common complications after total thyroidectomy. Preoperative serum vitamin D concentration has been postulated as a risk factor for this complication. However, the subject is still controversial and the role of vitamin D in the occurrence of hypocalcemia remains uncertain.
Objective: To evaluate the capability of preoperative vitamin D concentrations in predicting post-total thyroidectomy hypocalcemia.
Methods: Forty-seven total thyroidectomy patients were prospectively evaluated for serum 25(OH) vitamin D, calcium and parathyroid hormone before surgery, Calcium every 6 hours, and parathyroid hormone 8 hours post-operatively. Patients were divided according to postoperative corrected calcium into groups without (corrected calcium ≥8.5 mg/dL) and with hypocalcemia (corrected calcium <8.5 mg/dL), who were then evaluated for preoperative 25(OH) vitamin D values.
Results: A total of 72.3% of cases presented altered 25(OH) vitamin D preoperative serum concentrations and 51% evolved with postoperative hypocalcemia. The with and without hypocalcemia groups did not differ for preoperative 25(OH) vitamin D (p = 0.62). Univariate analysis showed that age (p = 0.03), postoperative PTH concentration (p = 0.02), and anatomopathological diagnosis of malignancy (p = 0.002) were predictors of postoperative hypocalcemia. In multivariate analysis only parathyroid hormone in postoperative (p = 0.02) was associated with post-total thyroidectomy hypocalcemia.
Conclusion: Preoperative serum concentrations of 25(OH) vitamin D were not predictors for post-total thyroidectomy hypocalcemia, whereas postoperative parathyroid hormone influenced the occurrence of this complication.
(Copyright © 2019 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.)
References: Am J Surg. 2009 Apr;197(4):439-46. (PMID: 19324110)
Br J Surg. 2014 Mar;101(4):307-20. (PMID: 24402815)
Arq Bras Endocrinol Metabol. 2012 Apr;56(3):168-72. (PMID: 22666731)
Braz J Otorhinolaryngol. 2010 Jan-Feb;76(1):71-7. (PMID: 20339692)
Am J Surg. 2011 May;201(5):685-91. (PMID: 21545922)
World J Surg. 2011 Feb;35(2):324-30. (PMID: 21153820)
Braz J Otorhinolaryngol. 2012 Jun;78(3):63-9. (PMID: 22714849)
J Am Coll Surg. 2001 Apr;192(4):465-8. (PMID: 11294403)
Otolaryngol Head Neck Surg. 2015 Mar;152(3):424-31. (PMID: 25475499)
Head Neck. 2017 Jul;39(7):1378-1381. (PMID: 28370789)
Arq Bras Endocrinol Metabol. 2014 Jul;58(5):411-33. (PMID: 25166032)
JAMA Otolaryngol Head Neck Surg. 2014 Apr;140(4):346-51. (PMID: 24577495)
Endocr Pract. 2015 Apr;21(4):348-54. (PMID: 25536969)
Endocrinol Metab Clin North Am. 2017 Dec;46(4):871-884. (PMID: 29080640)
World J Surg. 2013 Jul;37(7):1592-8. (PMID: 23532602)
Surgery. 2006 Dec;140(6):1016-23; discussion 1023-5. (PMID: 17188152)
فهرسة مساهمة: Keywords: Parathyroid hormone; Thyroidectomy; Vitamin D
المشرفين على المادة: 0 (Parathyroid Hormone)
1406-16-2 (Vitamin D)
تواريخ الأحداث: Date Created: 20190908 Date Completed: 20210216 Latest Revision: 20220902
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9422554
DOI: 10.1016/j.bjorl.2019.07.001
PMID: 31492617
قاعدة البيانات: MEDLINE
الوصف
تدمد:1808-8686
DOI:10.1016/j.bjorl.2019.07.001