دورية أكاديمية
Desonide nanoencapsulation with açai oil as oil core: Physicochemical characterization, photostability study and in vitro phototoxicity evaluation.
| العنوان: | Desonide nanoencapsulation with açai oil as oil core: Physicochemical characterization, photostability study and in vitro phototoxicity evaluation. |
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| المؤلفون: | Rosa P; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Santa Maria, Brazil., Friedrich ML; Departamento de Farmácia Industrial, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, Brazil., Dos Santos J; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Santa Maria, Brazil., Librelotto DRN; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Santa Maria, Brazil., Maurer LH; Programa de Pós-Graduação em Ciência e Tecnologia dos Alimentos, Universidade Federal de Santa Maria, Santa Maria, Brazil., Emanuelli T; Programa de Pós-Graduação em Ciência e Tecnologia dos Alimentos, Universidade Federal de Santa Maria, Santa Maria, Brazil., da Silva CB; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Santa Maria, Brazil; Departamento de Farmácia Industrial, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, Brazil., Adams AIH; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Santa Maria, Brazil; Departamento de Farmácia Industrial, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, Brazil. Electronic address: aadams@smail.ufsm.br. |
| المصدر: | Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2019 Oct; Vol. 199, pp. 111606. Date of Electronic Publication: 2019 Aug 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Switzerland NLM ID: 8804966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2682 (Electronic) Linking ISSN: 10111344 NLM ISO Abbreviation: J Photochem Photobiol B Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Elsevier Sequoia, 1987- |
| مواضيع طبية MeSH: | Anti-Inflammatory Agents/*chemistry , Desonide/*chemistry , Euterpe/*chemistry , Nanocapsules/*chemistry , Plant Oils/*chemistry , Polymethacrylic Acids/*chemistry, Animals ; Anti-Inflammatory Agents/pharmacology ; Cell Line ; Cell Survival/drug effects ; Desonide/pharmacology ; Drug Compounding/methods ; Drug Liberation ; Drug Stability ; Humans ; Light ; Mice ; Particle Size ; Photolysis ; Plant Oils/pharmacology ; Suspensions/chemistry ; Triglycerides/chemistry |
| مستخلص: | This study aimed to develop Eudragit® RL 100 nanocapsules loaded with desonide (DES) using açai oil (AO) or medium chain triglycerides (MCT) as oil core. Pre-formulation study showed that AO and MCT are suitable for nanocapsules preparation. The nanocapsules prepared with AO and MCT presented mean particle size around 165 and 131 nm, respectively; polydispersity index values <0.20, positive zeta potential values, drug content close to the theoretical value (0.25 mg mL -1 ), and DES encapsulation efficiency around 81%, regardless of the oil core (AO or MCT). Considering the photoinstability reported to DES, photodegradation studies were performed. The UV-A (365 nm) and UV-C (254 nm) photodegradation studies revealed less DES degradation when associated to the nanocapsules containing AO in comparison to those with MCT. The in vitro release study showed a biphasic release profile for both nanocapsule suspensions: an initial burst effect followed by a prolonged DES release. In addition, the formulations were considered non-phototoxic at 0.5 mg mL -1 when tested on 3 T3 murine fibroblasts and HaCaT human keratinocytes using the MTT and NRU viability assays. The irritant potential of the prepared nanocapsules and DES in free form were evaluated by HET-CAM method. All formulations were classified as slightly irritant, including the non-associate DES. In conclusion, the nanocapsule formulations developed in this study may be promising for therapeutic applications. (Copyright © 2019 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Irritant potential; Nanoparticles; Photostability; Phototoxic activity; açai oil |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 0 (Nanocapsules) 0 (Plant Oils) 0 (Polymethacrylic Acids) 0 (Suspensions) 0 (Triglycerides) 25086-15-1 (methylmethacrylate-methacrylic acid copolymer) J280872D1O (Desonide) |
| تواريخ الأحداث: | Date Created: 20190916 Date Completed: 20200113 Latest Revision: 20200113 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.jphotobiol.2019.111606 |
| PMID: | 31522112 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-2682 |
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| DOI: | 10.1016/j.jphotobiol.2019.111606 |