دورية أكاديمية
The cannabinoid agonist WIN-2 affects acquisition but not consolidation of a spatial information in training and retraining processes: Relation with transcriptional regulation of the endocannabinoid system?
| العنوان: | The cannabinoid agonist WIN-2 affects acquisition but not consolidation of a spatial information in training and retraining processes: Relation with transcriptional regulation of the endocannabinoid system? |
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| المؤلفون: | Alarcon TA; Laboratory of Molecular and Behavioral Neurobiology, Health Sciences Center, Federal University of Espírito Santo, Vitoria-ES, Brazil; Graduate Program in Biochemistry and Pharmacology, Health Sciences Center, Federal University of Espírito Santo, Vitoria-ES, Brazil., Areal LB; Laboratory of Molecular and Behavioral Neurobiology, Health Sciences Center, Federal University of Espírito Santo, Vitoria-ES, Brazil; Graduate Program in Neuroscience, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-MG, Brazil., Herlinger AL; Laboratory of Molecular and Behavioral Neurobiology, Health Sciences Center, Federal University of Espírito Santo, Vitoria-ES, Brazil; Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro-RJ, Brazil., Paiva KK; Department of Pharmaceutical Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitoria-ES, Brazil., Cicilini MA; Department of Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitoria-ES, Brazil., Martins-Silva C; Laboratory of Molecular and Behavioral Neurobiology, Health Sciences Center, Federal University of Espírito Santo, Vitoria-ES, Brazil; Graduate Program in Biochemistry and Pharmacology, Health Sciences Center, Federal University of Espírito Santo, Vitoria-ES, Brazil; Department of Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitoria-ES, Brazil., Pires RGW; Laboratory of Molecular and Behavioral Neurobiology, Health Sciences Center, Federal University of Espírito Santo, Vitoria-ES, Brazil; Graduate Program in Biochemistry and Pharmacology, Health Sciences Center, Federal University of Espírito Santo, Vitoria-ES, Brazil; Graduate Program in Neuroscience, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-MG, Brazil; Department of Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitoria-ES, Brazil. Electronic address: rita.pires@ufes.br. |
| المصدر: | Behavioural brain research [Behav Brain Res] 2020 Jan 13; Vol. 377, pp. 112231. Date of Electronic Publication: 2019 Sep 14. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8004872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7549 (Electronic) Linking ISSN: 01664328 NLM ISO Abbreviation: Behav Brain Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Benzoxazines/*pharmacology , Cannabinoid Receptor Agonists/*pharmacology , Cognitive Dysfunction/*chemically induced , Endocannabinoids/*metabolism , Gene Expression Regulation/*drug effects , Hippocampus/*drug effects , Memory Consolidation/*drug effects , Memory, Short-Term/*drug effects , Morpholines/*pharmacology , Naphthalenes/*pharmacology , Prefrontal Cortex/*drug effects , Spatial Learning/*drug effects , Transcription, Genetic/*drug effects, Animals ; Cognitive Dysfunction/metabolism ; Hippocampus/metabolism ; Male ; Mice ; Prefrontal Cortex/metabolism |
| مستخلص: | The endocannabinoid system is capable of modulating multiple physiological brain functions including learning and memory. Moreover, there is evidence that the processes of acquisition and consolidation have distinct biological basis. We used the cannabinoid agonist WIN 55,212-2 (WIN-2) to investigate whether chronic CB1 activation affects acquisition and consolidation differently by evaluating gene expression in the hippocampus (HIP) and prefrontal cortex (PFC). Swiss mice were treated with WIN-2 (2 mg/kg) and submitted to the Morris water maze to evaluate different aspects of memory. We observed short-term memory impairment in acquisition of the spatial task while consolidation remained unchanged. In the PFC, animals that received WIN-2 prior to the task exhibited increased expression of the 2-AG synthesis enzyme diacylglycerol lipase and decreased levels of the degradation enzyme monoacylglycerol lipase, while mice that were treated after the task for the evaluation of consolidation exhibited the opposite profile. With respect to genes related to AEA metabolism, no correlation between the molecular and behavioral data could be established. In this sense, the cognitive impairment in the acquisition promoted by WIN-2 treatment may be related to a possible increase in the concentration of 2-AG in the PFC. Overall, this study confirms the relevance of the endocannabinoid system in the modulation of cognitive processes. A better understanding of the mechanisms underlying endocannabinoids roles in cognition could provide guidance for the development of treatments to reduce the cognitive deficits caused by drug abuse. (Copyright © 2019 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Acquisition; Consolidation; Endocannabinoid system |
| المشرفين على المادة: | 0 (Benzoxazines) 0 (Cannabinoid Receptor Agonists) 0 (Endocannabinoids) 0 (Morpholines) 0 (Naphthalenes) 5H31GI9502 ((3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone) |
| تواريخ الأحداث: | Date Created: 20190919 Date Completed: 20210423 Latest Revision: 20210423 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.bbr.2019.112231 |
| PMID: | 31526770 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7549 |
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| DOI: | 10.1016/j.bbr.2019.112231 |