دورية أكاديمية
An in silico study examining the role of airway smooth muscle dynamics and airway compliance on the rate of airway re-narrowing after deep inspiration.
| العنوان: | An in silico study examining the role of airway smooth muscle dynamics and airway compliance on the rate of airway re-narrowing after deep inspiration. |
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| المؤلفون: | Rampadarath AK; Department of Mathematics, University of Auckland, New Zealand; Auckland Bioengineering Institute, University of Auckland, New Zealand., Donovan GM; Department of Mathematics, University of Auckland, New Zealand. |
| المصدر: | Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2020 Jan; Vol. 271, pp. 103257. Date of Electronic Publication: 2019 Sep 19. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 101140022 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1519 (Electronic) Linking ISSN: 15699048 NLM ISO Abbreviation: Respir Physiol Neurobiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier Science, c2002- |
| مواضيع طبية MeSH: | Computer Simulation* , Models, Biological*, Bronchoconstriction/*physiology , Inhalation/*physiology , Muscle, Smooth/*physiology, Asthma/physiopathology ; Humans |
| مستخلص: | Deep inspirations are a widely studied topic due to their varied effectiveness as a bronchodilator in asthmatic and non-asthmatic patients. Specifically, they are known to be effective at reversing bronchoconstriction in non-asthmatic patients but may fail to prevent bronchoconstriction in asthmatic patients. Inspired by a recent study on the effect of deep inspirations on the rate of re-narrowing of an isolated airway, we investigate whether the latch-bridge dynamics of smooth muscle cross-bridge theory, coupled with non-linear compliance of the airway wall, can account for the reported results: namely that only the rate of renarrowing after DI is sensitive to the interval between deep inspirations, while other measures are unaffected. We develop and present length- and pressure-controlled protocols which mimic both the experiments performed in the study, as well as simulate in vivo conditions respectively. Both protocols are simulated and show qualitative agreement with the results reported by the experiments, suggesting that latch-bridge dynamics coupled with airway wall non-compliance may be sufficient to explain these results. Moreover pressure- and length-controlled protocols show important differences which should be considered when designing in vitro experiments to mimic in vivo conditions. (Copyright © 2019 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Airway hyper-responsiveness; Asthma; Bronchoconstriction; Cross-bridge |
| تواريخ الأحداث: | Date Created: 20190923 Date Completed: 20200605 Latest Revision: 20200605 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.resp.2019.103257 |
| PMID: | 31542658 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1878-1519 |
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| DOI: | 10.1016/j.resp.2019.103257 |