دورية أكاديمية
أعرض في EDS

Probabilistic Information Modulates the Timed Response Inhibition Deficit in Aging Mice.

التفاصيل البيبلوغرافية
العنوان: Probabilistic Information Modulates the Timed Response Inhibition Deficit in Aging Mice.
المؤلفون: Gür E; Timing and Decision Making Laboratory, Koç University, Istanbul, Turkey.; Koç University Research Center for Translational Medicine, Istanbul, Turkey., Duyan YA; Timing and Decision Making Laboratory, Koç University, Istanbul, Turkey.; Koç University Research Center for Translational Medicine, Istanbul, Turkey., Balcı F; Timing and Decision Making Laboratory, Koç University, Istanbul, Turkey.; Koç University Research Center for Translational Medicine, Istanbul, Turkey.
المصدر: Frontiers in behavioral neuroscience [Front Behav Neurosci] 2019 Sep 03; Vol. 13, pp. 196. Date of Electronic Publication: 2019 Sep 03 (Print Publication: 2019).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477952 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5153 (Print) Linking ISSN: 16625153 NLM ISO Abbreviation: Front Behav Neurosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Research Foundation, 2007-
مستخلص: How interval timing is affected by aging constitutes one of the contemporary research questions. There is however a limited number of studies that investigate this research question in animal models of aging. The current study investigated how temporal decision-making is affected by aging. Initially, we trained young (2-3 month-old) and old C57BL/6J male mice (18-19 month-old) independently with short (3 s) and long (9 s) intervals by signaling, in each trial, the hopper associated with the interval that is in effect in that trial. The probability of short and long trials was manipulated (0.25 or 0.75) for different animals in each age group. During testing, both hoppers were illuminated, and thus active trial type was not differentiated. We expected mice to spontaneously combine the independently acquired time interval-location-probability information to adaptively guide their timing behavior in test trials. This adaptive ability and the resultant timing behavior were analyzed and compared between the age groups. Both young and old mice indeed adjusted their timing behavior in an abrupt fashion based on the independently acquired temporal-spatial-probabilistic information. The core timing ability of old mice was also intact. However, old mice had difficulty in terminating an ongoing timed response when the probability for the short trial was higher and this difference disappeared in the group that was exposed to a lower probability of short trials. These results suggest an inhibition problem in old mice as reflected through the threshold modulation process in timed decisions, which is cognitively penetrable to the probabilistic information.
References: Exp Aging Res. 2001 Jan-Mar;27(1):83-102. (PMID: 11205531)
Clin Neurophysiol. 2002 Jul;113(7):1172-82. (PMID: 12088714)
Psychol Aging. 2005 Mar;20(1):165-81. (PMID: 15769222)
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2008 Mar;15(2):232-55. (PMID: 17851981)
Clin Neuropsychol. 2008 Mar;22(2):262-72. (PMID: 17853147)
Psychopharmacology (Berl). 2008 Nov;201(1):67-80. (PMID: 18648777)
J Exp Psychol Learn Mem Cogn. 2008 Sep;34(5):1139-57. (PMID: 18763897)
Behav Processes. 2009 Jan;80(1):67-75. (PMID: 18950695)
Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2459-63. (PMID: 19188592)
Behav Neurosci. 2009 Dec;123(6):1353-8. (PMID: 20001119)
Psychol Aging. 2010 Jun;25(2):377-90. (PMID: 20545422)
J Gerontol B Psychol Sci Soc Sci. 2011 Jan;66(1):32-8. (PMID: 20974705)
Front Psychol. 2011 Dec 15;2:357. (PMID: 22180746)
Front Integr Neurosci. 2012 Mar 14;6:10. (PMID: 22435054)
Proc Natl Acad Sci U S A. 2012 May 29;109(22):8776-9. (PMID: 22592792)
J Neurosci. 2012 Jun 13;32(24):8401-12. (PMID: 22699920)
Psychol Aging. 2012 Dec;27(4):1152-63. (PMID: 23066805)
Neuropsychologia. 2013 Sep;51(11):2130-41. (PMID: 23856043)
Behav Neurosci. 2014 Aug;128(4):523-36. (PMID: 24841744)
Q J Exp Psychol (Hove). 2015;68(2):381-401. (PMID: 25026179)
Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):787-92. (PMID: 26733674)
Front Aging Neurosci. 2016 May 18;8:102. (PMID: 27242513)
Acta Psychol (Amst). 2016 Oct;170:74-83. (PMID: 27380621)
Psychon Bull Rev. 2018 Oct;25(5):1695-1716. (PMID: 29019064)
Anim Cogn. 2018 Jan;21(1):3-19. (PMID: 29027025)
Neurobiol Aging. 1987 Sep-Oct;8(5):393-402. (PMID: 3683720)
J Clin Exp Neuropsychol. 1986 Dec;8(6):710-26. (PMID: 3782451)
Psychol Aging. 1994 Dec;9(4):491-512. (PMID: 7893421)
J Exp Psychol Anim Behav Process. 1994 Apr;20(2):135-55. (PMID: 8189184)
Psychol Rev. 1996 Jul;103(3):403-28. (PMID: 8759042)
Eur J Clin Invest. 1998 Nov;28(11):944-9. (PMID: 9824440)
فهرسة مساهمة: Keywords: cognitive aging; interval timing; probabilistic reasoning; response inhibition; temporal discrimination; temporal processing
تواريخ الأحداث: Date Created: 20190926 Latest Revision: 20200930
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6734164
DOI: 10.3389/fnbeh.2019.00196
PMID: 31551727
قاعدة البيانات: MEDLINE
الوصف
تدمد:1662-5153
DOI:10.3389/fnbeh.2019.00196