دورية أكاديمية

Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer.

التفاصيل البيبلوغرافية
العنوان: Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer.
المؤلفون: Lin W; Genentech, South San Francisco, CA, United States., Xu D; Genentech, South San Francisco, CA, United States., Austin CD; Genentech, South San Francisco, CA, United States., Caplazi P; Genentech, South San Francisco, CA, United States., Senger K; Genentech, South San Francisco, CA, United States., Sun Y; Genentech, South San Francisco, CA, United States., Jeet S; Genentech, South San Francisco, CA, United States., Young J; Genentech, South San Francisco, CA, United States., Delarosa D; Genentech, South San Francisco, CA, United States., Suto E; Genentech, South San Francisco, CA, United States., Huang Z; Genentech, South San Francisco, CA, United States., Zhang J; Genentech, South San Francisco, CA, United States., Yan D; Genentech, South San Francisco, CA, United States., Corzo C; Genentech, South San Francisco, CA, United States., Barck K; Genentech, South San Francisco, CA, United States., Rajan S; Genentech, South San Francisco, CA, United States., Looney C; Genentech, South San Francisco, CA, United States., Gandham V; Genentech, South San Francisco, CA, United States., Lesch J; Genentech, South San Francisco, CA, United States., Liang WC; Genentech, South San Francisco, CA, United States., Mai E; Genentech, South San Francisco, CA, United States., Ngu H; Genentech, South San Francisco, CA, United States., Ratti N; Genentech, South San Francisco, CA, United States., Chen Y; Genentech, South San Francisco, CA, United States., Misner D; Genentech, South San Francisco, CA, United States., Lin T; Genentech, South San Francisco, CA, United States., Danilenko D; Genentech, South San Francisco, CA, United States., Katavolos P; Genentech, South San Francisco, CA, United States., Doudemont E; Genentech, South San Francisco, CA, United States., Uppal H; Genentech, South San Francisco, CA, United States., Eastham J; Genentech, South San Francisco, CA, United States., Mak J; Genentech, South San Francisco, CA, United States., de Almeida PE; Genentech, South San Francisco, CA, United States., Bao K; Genentech, South San Francisco, CA, United States., Hadadianpour A; Genentech, South San Francisco, CA, United States., Keir M; Genentech, South San Francisco, CA, United States., Carano RAD; Genentech, South San Francisco, CA, United States., Diehl L; Genentech, South San Francisco, CA, United States., Xu M; Genentech, South San Francisco, CA, United States., Wu Y; Genentech, South San Francisco, CA, United States., Weimer RM; Genentech, South San Francisco, CA, United States., DeVoss J; Genentech, South San Francisco, CA, United States., Lee WP; Genentech, South San Francisco, CA, United States., Balazs M; Genentech, South San Francisco, CA, United States., Walsh K; Genentech, South San Francisco, CA, United States., Alatsis KR; Genentech, South San Francisco, CA, United States., Martin F; Genentech, South San Francisco, CA, United States., Zarrin AA; Genentech, South San Francisco, CA, United States.
المصدر: Frontiers in immunology [Front Immunol] 2019 Sep 04; Vol. 10, pp. 2019. Date of Electronic Publication: 2019 Sep 04 (Print Publication: 2019).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: Homeostasis/*immunology , Inflammation/*immunology , Interleukins/*immunology , Macrophage Colony-Stimulating Factor/*immunology , Macrophages/*immunology , Neoplasms/*immunology, Animals ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Disease Models, Animal ; Homeostasis/genetics ; Humans ; Inflammation/genetics ; Inflammation/metabolism ; Interleukins/genetics ; Interleukins/metabolism ; Macrophage Colony-Stimulating Factor/genetics ; Macrophage Colony-Stimulating Factor/metabolism ; Macrophages/metabolism ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Mice, Inbred NZB ; Mice, Knockout ; Myeloid Cells/immunology ; Myeloid Cells/metabolism ; Neoplasms/genetics ; Neoplasms/metabolism
مستخلص: Colony-stimulating factor 1 (CSF1) and interleukin 34 (IL34) signal via the CSF1 receptor to regulate macrophage differentiation. Studies in IL34- or CSF1-deficient mice have revealed that IL34 function is limited to the central nervous system and skin during development. However, the roles of IL34 and CSF1 at homeostasis or in the context of inflammatory diseases or cancer in wild-type mice have not been clarified in vivo . By neutralizing CSF1 and/or IL34 in adult mice, we identified that they play important roles in macrophage differentiation, specifically in steady-state microglia, Langerhans cells, and kidney macrophages. In several inflammatory models, neutralization of both CSF1 and IL34 contributed to maximal disease protection. However, in a myeloid cell-rich tumor model, CSF1 but not IL34 was required for tumor-associated macrophage accumulation and immune homeostasis. Analysis of human inflammatory conditions reveals IL34 upregulation that may account for the protection requirement of IL34 blockade. Furthermore, evaluation of IL34 and CSF1 blockade treatment during Listeria infection reveals no substantial safety concerns. Thus, IL34 and CSF1 play non-redundant roles in macrophage differentiation, and therapeutic intervention targeting IL34 and/or CSF1 may provide an effective treatment in macrophage-driven immune-pathologies.
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فهرسة مساهمة: Keywords: CSF1 and Il34 inhibition; CSF1R; Langerhans cells; cancer; inflammation; macrophage; microglia; monocyte
المشرفين على المادة: 0 (Interleukins)
0 (interleukin-34, mouse)
81627-83-0 (Macrophage Colony-Stimulating Factor)
تواريخ الأحداث: Date Created: 20190926 Date Completed: 20201019 Latest Revision: 20201019
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6736990
DOI: 10.3389/fimmu.2019.02019
PMID: 31552020
قاعدة البيانات: MEDLINE