دورية أكاديمية
Coumarin-based Scaffold as α-glucosidase Inhibitory Activity: Implication for the Development of Potent Antidiabetic Agents.
| العنوان: | Coumarin-based Scaffold as α-glucosidase Inhibitory Activity: Implication for the Development of Potent Antidiabetic Agents. |
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| المؤلفون: | Tafesse TB; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences-International Campus (IC-TUMS), Tehran, Iran.; Department of Medicinal Chemistry, Faculty of Pharmacy, Drug Design and Development Research Center and The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.; School of Pharmacy, College of Health & Medical Sciences, Haramaya University, Harar, Ethiopia., Bule MH; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences-International Campus (IC-TUMS), Tehran, Iran.; Department of Medicinal Chemistry, Faculty of Pharmacy, Drug Design and Development Research Center and The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.; Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia., Khoobi M; Department of Pharmaceutical Biomaterials, Medical Biomaterials Research Center and The Institute of Pharmaceutical Sciences (TIPS), Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran., Faramarzi MA; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran., Abdollahi M; Department of Pharmacology and Toxicology, Faculty of Pharmacy and The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran., Amini M; Department of Medicinal Chemistry, Faculty of Pharmacy, Drug Design and Development Research Center and The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran. |
| المصدر: | Mini reviews in medicinal chemistry [Mini Rev Med Chem] 2020; Vol. 20 (2), pp. 134-151. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 101094212 Publication Model: Print Cited Medium: Internet ISSN: 1875-5607 (Electronic) Linking ISSN: 13895575 NLM ISO Abbreviation: Mini Rev Med Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hilversum, The Netherlands; Boca Raton, FL : Bentham Science Publishers, c2001- |
| مواضيع طبية MeSH: | Coumarins/*pharmacology , Diabetes Mellitus, Type 2/*drug therapy , Glycoside Hydrolase Inhibitors/*pharmacology , Hypoglycemic Agents/*pharmacology , alpha-Glucosidases/*metabolism, Animals ; Coumarins/chemistry ; Glycoside Hydrolase Inhibitors/chemistry ; Humans ; Hypoglycemic Agents/chemistry ; Molecular Structure ; Structure-Activity Relationship |
| مستخلص: | Background: Delaying the absorption of glucose through α-glucosidase enzyme inhibition is one of the therapeutic approaches in the management of Type 2 diabetes, which can reduce the incidence of postprandial hyperglycemia. The existence of chronic postprandial hyperglycemia impaired the endogenous antioxidant defense by inducing oxidative stress-induced pancreatic β-cell destruction through uncontrolled generation of free radicals such as ROS, which in turn, leads to various macrovascular and microvascular complications. The currently available α -glucosidase inhibitors, for instance, acarbose, have some side effects such as hypoglycemia at higher doses, liver problems, meteorism, diarrhea, and lactic acidosis. Therefore, there is an urgent need to discover and develop potential α-glucosidase inhibitors. Objective: Based on suchmotifs, researchers are intrigued to search for the best scaffold that displays various biological activities. Among them, coumarin scaffold has attracted great attention. The compound and its derivatives can be isolated from various natural products and/or synthesized for the development of novel α-glucosidase inhibitors. Results: This study focused on coumarin and its derivatives as well as on their application as potent antidiabetic agents and has also concentrated on the structure-activity relationship. Conclusion: This review describes the applications of coumarin-containing derivatives as α - glucosidase inhibitors based on published reports which will be useful for innovative approaches in the search for novel coumarin-based antidiabetic drugs with less toxicity and more potency. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: Coumarin derivatives; SAR; antidiabetic drugs; natural products; type 2 diabetes; α-glucosidase. |
| المشرفين على المادة: | 0 (Coumarins) 0 (Glycoside Hydrolase Inhibitors) 0 (Hypoglycemic Agents) EC 3.2.1.20 (alpha-Glucosidases) |
| تواريخ الأحداث: | Date Created: 20190926 Date Completed: 20201013 Latest Revision: 20201013 |
| رمز التحديث: | 20231215 |
| DOI: | 10.2174/1389557519666190925162536 |
| PMID: | 31553294 |
| قاعدة البيانات: | MEDLINE |
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