دورية أكاديمية
أعرض في EDS

Development of experimental silicosis in inbred and outbred mice depends on instillation volume.

التفاصيل البيبلوغرافية
العنوان: Development of experimental silicosis in inbred and outbred mice depends on instillation volume.
المؤلفون: Mayeux JM; Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA., Kono DH; Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA., Pollard KM; Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. mpollard@scripps.edu.
المصدر: Scientific reports [Sci Rep] 2019 Oct 02; Vol. 9 (1), pp. 14190. Date of Electronic Publication: 2019 Oct 02.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Lung/*drug effects , Silicon Dioxide/*pharmacology , Silicosis/*metabolism, Animals ; Bronchoalveolar Lavage Fluid ; Disease Models, Animal ; Humans ; Inflammation/chemically induced ; Inflammation/genetics ; Inflammation/pathology ; Lung/pathology ; Mice ; Silicon Dioxide/toxicity ; Silicosis/genetics ; Silicosis/pathology
مستخلص: There is considerable variation in methods to induce experimental silicosis with the effects of dose and route of exposure being well documented. However, to what extent the volume of silica suspension alters the dispersion and severity of silicosis has not been adequately investigated. In this study, the optimal volume of a crystalline silica suspension required to obtain uniform distribution and greatest incidence and severity of silicosis was determined in inbred and outbred mice. Silica dispersal, detected by co-inspiration with India ink and polarized light microscopy, was highly dependent upon volume. Furthermore, although peribronchitis, perivasculitis, and increases in bronchoalveolar lavage fluid cell numbers were detected a lower doses and volumes, significant alveolitis required exposure to 5 mg of silica in 50 μl. This dose and volume of transoral instillation led to a greater penetrance of silicosis in the genetically heterogeneous Diversity Outbred strain as well as greater alveolar inflammation typical of the silicosis in human disease. These findings underscore the critical importance of instillation volume on the induction, severity, and type of inflammatory pathology in experimental silicosis.
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معلومات مُعتمدة: R01 ES029581 United States ES NIEHS NIH HHS; T32 AI007244 United States AI NIAID NIH HHS
المشرفين على المادة: 7631-86-9 (Silicon Dioxide)
تواريخ الأحداث: Date Created: 20191004 Date Completed: 20201102 Latest Revision: 20210110
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6775097
DOI: 10.1038/s41598-019-50725-9
PMID: 31578388
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-019-50725-9