دورية أكاديمية
Cardiovascular biomarkers and echocardiographic findings at rest and during graded hypovolemic stress in women with recurrent vasovagal syncope.
| العنوان: | Cardiovascular biomarkers and echocardiographic findings at rest and during graded hypovolemic stress in women with recurrent vasovagal syncope. |
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| المؤلفون: | Lindenberger M; Department of Cardiology, Linköping University Hospital, Linköping, Sweden.; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden., Fedorowski A; Department of Clinical Sciences, Lund University, Malmö, Sweden.; Department of Cardiology, Skåne University Hospital, Malmö, Sweden., Melander O; Department of Clinical Sciences, Lund University, Malmö, Sweden., Gallo W; Department of Clinical Sciences, Lund University, Malmö, Sweden., Engvall J; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden., Skoog J; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. |
| المصدر: | Journal of cardiovascular electrophysiology [J Cardiovasc Electrophysiol] 2019 Dec; Vol. 30 (12), pp. 2936-2943. Date of Electronic Publication: 2019 Oct 14. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Country of Publication: United States NLM ID: 9010756 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8167 (Electronic) Linking ISSN: 10453873 NLM ISO Abbreviation: J Cardiovasc Electrophysiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Malden, MA : Blackwell Original Publication: Mt. Kisco, N.Y. : Futura Pub., c1990- |
| مواضيع طبية MeSH: | Echocardiography, Three-Dimensional* , Hemodynamics* , Stress, Physiological*, Biomarkers/*blood , Hypovolemia/*physiopathology , Syncope, Vasovagal/*blood , Syncope, Vasovagal/*diagnostic imaging, Adolescent ; Adult ; Cardiac Output ; Case-Control Studies ; Endothelin-1/blood ; Female ; Glycopeptides/blood ; Humans ; Lower Body Negative Pressure ; Norepinephrine/blood ; Peptide Fragments/blood ; Predictive Value of Tests ; Recurrence ; Sex Factors ; Syncope, Vasovagal/physiopathology ; Time Factors ; Vasopressins/blood ; Young Adult |
| مستخلص: | Introduction: Vasovagal reflex is the most common type of syncope but its etiology is not fully elucidated. Venous return and cardiac output are key in hemodynamic control. The aim of the study was to assess cardiovascular biomarkers and echocardiographic measures at rest and during hypovolemia in women with and without a history of vasovagal syncope. Methods: Fourteen women (aged 18-30) suffering from recurrent vasovagal syncope and 15 age-matched healthy women were included. Graded lower body negative pressure (LBNP) was used to create central hypovolemic stress until signs of presyncope occurred. Echocardiography was applied at rest and throughout LBNP. Cardiovascular biomarkers: copeptin, mid-regional proadrenomedullin, mid-regional pro-ANP, C-terminal proendothelin-1, and plasma norepinephrine were measured both at rest and throughout graded hypovolemia to presyncope. Results: Women prone to vasovagal syncope presented with a narrower right ventricle (RV) (29 ± 1 vs 32 ± 1 mm, P < .05), smaller left atrium (36 ± 2 vs 47 ± 3 cm 3 , P < .01) and lower cardiac output at rest (3.1 ± 0.2 vs 3.7 ± 0.2 L/min, P < .05) and during graded hypovolemia (P < .05). Copeptin was elevated at rest (4.3 ± 0.8 vs 2.5 ± 0.2 pmol/L, P < .05) and increased more in women with vasovagal syncope during progression of LBNP (P < .01). At rest, lower C-terminal proendothelin-1 (35 ± 5 vs 46 ± 2 pmol/L, P < .05) and higher norepinephrine levels (1.1 ± 0.1 vs 0.8 ± 0.1 nmol/L, P < .01) were seen in women with vasovagal syncope. Conclusion: Women prone to vasovagal syncope demonstrate reduced cardiac preload, lower cardiac output, as well as increased release of vasopressin in rest and during hypovolemic challenge. The results emphasize the importance of venous return and cardiac output in the pathogenesis of vasovagal syncope. (© 2019 Wiley Periodicals, Inc.) |
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| معلومات مُعتمدة: | 160691 International Medical Research Council of Southeast Sweden Grant; LIO-391351 International County Council of Östergötland Grants; LIO-441081 International County Council of Östergötland Grants; LIO-541501 International County Council of Östergötland Grants; 20160519 International Swedish Heart and Lung Foundation |
| فهرسة مساهمة: | Keywords: adrenomedullin; biomarkers; cardiac output; copeptin; echocardiography; endothelin-1; vasovagal syncope; women |
| المشرفين على المادة: | 0 (Biomarkers) 0 (C-terminal proendothelin-1) 0 (Endothelin-1) 0 (Glycopeptides) 0 (Peptide Fragments) 0 (copeptins) 11000-17-2 (Vasopressins) X4W3ENH1CV (Norepinephrine) |
| تواريخ الأحداث: | Date Created: 20191004 Date Completed: 20201023 Latest Revision: 20201023 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1111/jce.14207 |
| PMID: | 31578800 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1540-8167 |
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| DOI: | 10.1111/jce.14207 |