دورية أكاديمية
The Trypanosomal Transferrin Receptor of Trypanosoma Brucei-A Review.
| العنوان: | The Trypanosomal Transferrin Receptor of Trypanosoma Brucei-A Review. |
|---|---|
| المؤلفون: | Kariuki CK; Laboratory of Cellular and Molecular Interactions (CMIM), Vrije Universiteit Brussels, Brussels, 1050 Ixelles, Belgium. Christopher.kariuki@vub.be.; Department of Tropical and Infectious Diseases, Institute of Primate Research (IPR), Nairobi 00502, Kenya. Christopher.kariuki@vub.be., Stijlemans B; Laboratory of Cellular and Molecular Interactions (CMIM), Vrije Universiteit Brussels, Brussels, 1050 Ixelles, Belgium.; Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Gent 9052, Belgium., Magez S; Laboratory of Cellular and Molecular Interactions (CMIM), Vrije Universiteit Brussels, Brussels, 1050 Ixelles, Belgium. Stefan.magez@ghent.ac.kr.; Laboratory for Biomedical Research, Ghent University Global Campus, Yeonsu-Gu, Incheon 219220, Korea. Stefan.magez@ghent.ac.kr. |
| المصدر: | Tropical medicine and infectious disease [Trop Med Infect Dis] 2019 Oct 01; Vol. 4 (4). Date of Electronic Publication: 2019 Oct 01. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101709042 Publication Model: Electronic Cited Medium: Internet ISSN: 2414-6366 (Electronic) Linking ISSN: 24146366 NLM ISO Abbreviation: Trop Med Infect Dis Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, [2016]- |
| مستخلص: | Iron is an essential element for life. Its uptake and utility requires a careful balancing with its toxic capacity, with mammals evolving a safe and bio-viable means of its transport and storage. This transport and storage is also utilized as part of the iron-sequestration arsenal employed by the mammalian hosts' 'nutritional immunity' against parasites. Interestingly, a key element of iron transport, i.e., serum transferrin (Tf), is an essential growth factor for parasitic haemo-protozoans of the genus Trypanosoma . These are major mammalian parasites causing the diseases human African trypanosomosis (HAT) and animal trypanosomosis (AT). Using components of their well-characterized immune evasion system, bloodstream Trypanosoma brucei parasites adapt and scavenge for the mammalian host serum transferrin within their broad host range. The expression site associated genes (ESAG6 and 7) are utilized to construct a heterodimeric serum Tf binding complex which, within its niche in the flagellar pocket, and coupled to the trypanosomes' fast endocytic rate, allows receptor-mediated acquisition of essential iron from their environment. This review summarizes current knowledge of the trypanosomal transferrin receptor (TfR), with emphasis on the structure and function of the receptor, both in physiological conditions as well as in conditions where the iron supply to parasites is being limited. Potential applications using current knowledge of the parasite receptor are also briefly discussed, primarily focused on potential therapeutic interventions. Competing Interests: The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. |
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| معلومات مُعتمدة: | PAI-IAP N. P7/41 Inter-university Attraction Pole Program; FWOG015016N Fonds Wetenschappelijk Onderzoek |
| فهرسة مساهمة: | Keywords: flagellar pocket; iron; nutritional immunity; transferrin; transferrin receptor; trypanosomosis |
| تواريخ الأحداث: | Date Created: 20191005 Latest Revision: 20201001 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6958415 |
| DOI: | 10.3390/tropicalmed4040126 |
| PMID: | 31581506 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2414-6366 |
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| DOI: | 10.3390/tropicalmed4040126 |