دورية أكاديمية
Puma genomes from North and South America provide insights into the genomic consequences of inbreeding.
العنوان: | Puma genomes from North and South America provide insights into the genomic consequences of inbreeding. |
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المؤلفون: | Saremi NF; Department of Biomolecular Engineering, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA, 95064, USA., Supple MA; Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA, 95064, USA., Byrne A; Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA, 95064, USA., Cahill JA; Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA, 95064, USA.; Laboratory of Neurogenetics of Language, Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA., Coutinho LL; Laboratório de Biotecnologia Animal, Departamento de Zootecnia, ESALQ, Universidade de São Paulo, Caixa Postal 09, Piracicaba, SP, 13418-900, Brazil., Dalén L; Department of Bioinformatics and Genetics, Swedish Museum of Natural History, P.O. Box 50007, Stockholm, 10405, Sweden., Figueiró HV; Escola de Ciências, Pontifical Catholic University of Rio Grande do Sul, Avenida Ipiranga, 6681-Partenon, Porto Alegre-RS, 90619-900, Brazil., Johnson WE; Smithsonian Conservation Biology Institute, Smithsonian Institution, 600 Maryland Avenue SW, Washington, DC, 20002, USA.; Walter Reed Biosystematics Unit, Smithsonian Institution, 4210 Silver Hill Road, Suitland, MD, 20746, USA., Milne HJ; Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA, 95064, USA., O'Brien SJ; Theodosius Dobzhansky Center for Genome Bioinformatics, Saint Petersburg State University, 41 Sredniy Prospekt, Saint Petersburg, 199004, Russia., O'Connell B; Department of Biomolecular Engineering, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA, 95064, USA.; Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR, 97239-3098, USA., Onorato DP; Fish and Wildlife Research Institute, Florida Fish and Wildlife Conservation Commission, 298 Sabal Palm Road, Naples, FL, 34114, USA., Riley SPD; Santa Monica Mountains National Recreation Area, 401 West Hillcrest Drive, Thousand Oaks, CA, 91360, USA.; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, 610 Charles E. Young Drive South, Los Angeles, CA, 90095-1601, USA., Sikich JA; Santa Monica Mountains National Recreation Area, 401 West Hillcrest Drive, Thousand Oaks, CA, 91360, USA., Stahler DR; Yellowstone Center for Resources, P.O. Box 168, Yellowstone National Park, WY, 82190, USA., Villela PMS; EcoMol Consultoria e Projetos, Avenida Limeira, 1131- Areiao, Piracicaba-SP, Brazil., Vollmers C; Department of Biomolecular Engineering, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA, 95064, USA., Wayne RK; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, 610 Charles E. Young Drive South, Los Angeles, CA, 90095-1601, USA., Eizirik E; Escola de Ciências, Pontifical Catholic University of Rio Grande do Sul, Avenida Ipiranga, 6681-Partenon, Porto Alegre-RS, 90619-900, Brazil., Corbett-Detig RB; Department of Biomolecular Engineering, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA, 95064, USA., Green RE; Department of Biomolecular Engineering, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA, 95064, USA., Wilmers CC; Environmental Studies Department, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA, 95064, USA., Shapiro B; Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA, 95064, USA. beth.shapiro@gmail.com.; Howard Hughes Medical Institute, 400 Jones Bridge Road, Chevy Chase, MD, 20815, USA. beth.shapiro@gmail.com. |
المصدر: | Nature communications [Nat Commun] 2019 Oct 18; Vol. 10 (1), pp. 4769. Date of Electronic Publication: 2019 Oct 18. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
مواضيع طبية MeSH: | Genome-Wide Association Study/*methods , Genomics/*methods , Inbreeding/*methods , Puma/*genetics, Animals ; Gene Flow ; Genetic Variation ; Genetics, Population ; Geography ; North America ; Phylogeny ; Puma/classification ; South America |
مستخلص: | Pumas are the most widely distributed felid in the Western Hemisphere. Increasingly, however, human persecution and habitat loss are isolating puma populations. To explore the genomic consequences of this isolation, we assemble a draft puma genome and a geographically broad panel of resequenced individuals. We estimate that the lineage leading to present-day North American pumas diverged from South American lineages 300-100 thousand years ago. We find signatures of close inbreeding in geographically isolated North American populations, but also that tracts of homozygosity are rarely shared among these populations, suggesting that assisted gene flow would restore local genetic diversity. The genome of a Florida panther descended from translocated Central American individuals has long tracts of homozygosity despite recent outbreeding. This suggests that while translocations may introduce diversity, sustaining diversity in small and isolated populations will require either repeated translocations or restoration of landscape connectivity. Our approach provides a framework for genome-wide analyses that can be applied to the management of similarly small and isolated populations. |
التعليقات: | Erratum in: Nat Commun. 2019 Nov 21;10(1):5276. (PMID: 31754100) |
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معلومات مُعتمدة: | R35 GM128932 United States GM NIGMS NIH HHS; T32 HG008345 United States HG NHGRI NIH HHS |
تواريخ الأحداث: | Date Created: 20191020 Date Completed: 20200124 Latest Revision: 20220421 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC6800433 |
DOI: | 10.1038/s41467-019-12741-1 |
PMID: | 31628318 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2041-1723 |
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DOI: | 10.1038/s41467-019-12741-1 |