دورية أكاديمية
Microenvironmental Heterogeneity in Brain Malignancies.
| العنوان: | Microenvironmental Heterogeneity in Brain Malignancies. |
|---|---|
| المؤلفون: | Perus LJM; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.; Department of Physiology, Faculty of Medicine, McGill University, Montreal, QC, Canada., Walsh LA; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.; Department of Human Genetics, Faculty of Medicine, McGill University, Montreal, QC, Canada. |
| المصدر: | Frontiers in immunology [Front Immunol] 2019 Oct 01; Vol. 10, pp. 2294. Date of Electronic Publication: 2019 Oct 01 (Print Publication: 2019). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Biological Variation, Population* , Tumor Microenvironment*, Brain Neoplasms/*diagnosis, Brain Neoplasms/etiology ; Brain Neoplasms/secondary ; Brain Neoplasms/therapy ; Combined Modality Therapy ; Disease Management ; Disease Susceptibility ; Humans ; Neovascularization, Pathologic ; Recurrence |
| مستخلص: | Brain tumors are among the deadliest malignancies. The brain tumor microenvironment (TME) hosts a unique collection of cells, soluble factors, and extracellular matrix components that regulate disease evolution of both primary and metastatic brain malignancies. It is established that macrophages and other myeloid cells are abundant in the brain TME and strongly correlate with aggressive phenotypes and distinct genetic signatures, while lymphoid cells are less frequent but are now known to have a pronounced effect on disease progression. Different types of brain tumors vary widely in their microenvironmental contexture, and the proportion of various stromal components impacts tumor biology. Indeed, emerging evidence suggests an intimate link between the molecular signature of tumor cells and the composition of the TME, shedding light on the mechanisms which underlie microenvironmental heterogeneity in brain cancer. In this review, we discuss the association between TME composition and the diverse molecular profiles of primary gliomas and brain metastases. We also discuss the implications of these associations on the efficacy of immunotherapy in brain malignancies. An appreciation for the causes and functional consequences of microenvironmental heterogeneity in brain cancer will be of crucial importance to the rational design of microenvironment-targeted therapies for these deadly diseases. (Copyright © 2019 Perus and Walsh.) |
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| فهرسة مساهمة: | Keywords: brain cancer; brain metastasis; glioblastoma; glioma; immunotherapy; tumor microenvironment |
| تواريخ الأحداث: | Date Created: 20191022 Date Completed: 20201030 Latest Revision: 20201030 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6779728 |
| DOI: | 10.3389/fimmu.2019.02294 |
| PMID: | 31632393 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2019.02294 |