دورية أكاديمية
أعرض في EDS

The Tudor SND1 protein is an m 6 A RNA reader essential for replication of Kaposi's sarcoma-associated herpesvirus.

التفاصيل البيبلوغرافية
العنوان: The Tudor SND1 protein is an m 6 A RNA reader essential for replication of Kaposi's sarcoma-associated herpesvirus.
المؤلفون: Baquero-Perez B; School of Molecular and Cellular Biology, Faculty of Biological Sciences, Astbury Centre of Structural Molecular Biology, University of Leeds, Leeds, United Kingdom.; Astbury Centre of Structural Molecular Biology, University of Leeds, Leeds, United Kingdom., Antanaviciute A; Leeds Institute of Medical Research, School of Medicine, University of Leeds, St James's University Hospital, Leeds, United Kingdom., Yonchev ID; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom.; Sheffield Institute For Nucleic Acids, University of Sheffield, Sheffield, United Kingdom., Carr IM; Leeds Institute of Medical Research, School of Medicine, University of Leeds, St James's University Hospital, Leeds, United Kingdom., Wilson SA; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom.; Sheffield Institute For Nucleic Acids, University of Sheffield, Sheffield, United Kingdom., Whitehouse A; School of Molecular and Cellular Biology, Faculty of Biological Sciences, Astbury Centre of Structural Molecular Biology, University of Leeds, Leeds, United Kingdom.; Astbury Centre of Structural Molecular Biology, University of Leeds, Leeds, United Kingdom.; Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa.
المصدر: ELife [Elife] 2019 Oct 24; Vol. 8. Date of Electronic Publication: 2019 Oct 24.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Host-Pathogen Interactions* , Virus Replication*, Adenosine/*analogs & derivatives , Endonucleases/*metabolism , Herpesvirus 8, Human/*growth & development , RNA, Messenger/*metabolism , RNA, Viral/*metabolism, Adenosine/metabolism ; Computational Biology ; HEK293 Cells ; Humans ; Protein Binding ; Sequence Analysis, RNA
مستخلص: N 6 -methyladenosine (m 6 A) is the most abundant internal RNA modification of cellular mRNAs. m 6 A is recognised by YTH domain-containing proteins, which selectively bind to m 6 A-decorated RNAs regulating their turnover and translation. Using an m 6 A-modified hairpin present in the Kaposi's sarcoma associated herpesvirus (KSHV) ORF50 RNA, we identified seven members from the 'Royal family' as putative m 6 A readers, including SND1. RIP-seq and eCLIP analysis characterised the SND1 binding profile transcriptome-wide, revealing SND1 as an m 6 A reader. We further demonstrate that the m 6 A modification of the ORF50 RNA is critical for SND1 binding, which in turn stabilises the ORF50 transcript. Importantly, SND1 depletion leads to inhibition of KSHV early gene expression showing that SND1 is essential for KSHV lytic replication. This work demonstrates that members of the 'Royal family' have m 6 A-reading ability, greatly increasing their epigenetic functions beyond protein methylation.
Competing Interests: BB, AA, IY, IC, SW, AW No competing interests declared
(© 2019, Baquero-Perez et al.)
References: Cell Host Microbe. 2016 Nov 9;20(5):654-665. (PMID: 27773535)
PLoS Genet. 2012;8(5):e1002717. (PMID: 22615581)
J Biol Chem. 2015 Oct 9;290(41):24902-13. (PMID: 26318451)
Curr Protoc Mol Biol. 2006 Aug;Chapter 27:Unit 27.4. (PMID: 18265380)
Cell Res. 2017 Sep;27(9):1115-1127. (PMID: 28809393)
Nature. 2020 Jul;583(7818):711-719. (PMID: 32728246)
Trends Biochem Sci. 2014 Nov;39(11):536-47. (PMID: 25277115)
Nat Microbiol. 2016 Oct 31;2:16201. (PMID: 27798559)
Plant Cell. 2010 May;22(5):1575-91. (PMID: 20484005)
Mol Cell. 2016 Jul 21;63(2):306-317. (PMID: 27373337)
FEBS J. 2015 Mar;282(5):874-90. (PMID: 25559396)
Bioinformatics. 2014 Apr 1;30(7):923-30. (PMID: 24227677)
PLoS One. 2010 Nov 02;5(11):e13559. (PMID: 21072162)
Int J Oncol. 2015 Feb;46(2):465-73. (PMID: 25405367)
PLoS Pathog. 2018 Apr 16;14(4):e1006995. (PMID: 29659627)
Genomics Proteomics Bioinformatics. 2018 Apr;16(2):99-107. (PMID: 29715522)
Cell. 2015 Jun 4;161(6):1388-99. (PMID: 26046440)
Cell. 2016 Jan 28;164(3):487-98. (PMID: 26777405)
OMICS. 2012 May;16(5):284-7. (PMID: 22455463)
Genome Biol. 2014;15(12):550. (PMID: 25516281)
Nat Chem Biol. 2014 Nov;10(11):927-9. (PMID: 25242552)
Cell. 2017 May 18;169(5):824-835.e14. (PMID: 28525753)
Virology. 1998 Dec 20;252(2):304-12. (PMID: 9878608)
Elife. 2016 Jul 02;5:. (PMID: 27371828)
Nat Commun. 2016 Aug 25;7:12626. (PMID: 27558897)
Cell Host Microbe. 2017 Sep 13;22(3):377-386.e5. (PMID: 28910636)
Nat Microbiol. 2018 Jan;3(1):108-120. (PMID: 29109479)
PLoS Pathog. 2015 Nov 20;11(11):e1005274. (PMID: 26587836)
Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20336-41. (PMID: 19918066)
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D493-6. (PMID: 14681465)
Nat Struct Mol Biol. 2017 Oct;24(10):870-878. (PMID: 28869609)
Mol Cell. 2018 Sep 20;71(6):986-1000.e11. (PMID: 30197299)
Mol Cell. 2016 Feb 18;61(4):507-519. (PMID: 26876937)
FEBS Lett. 2010 Aug 20;584(16):3525-32. (PMID: 20643132)
Nucleic Acids Res. 2017 Jun 2;45(10):6051-6063. (PMID: 28334903)
J Am Chem Soc. 2017 Dec 6;139(48):17249-17252. (PMID: 29140688)
Front Microbiol. 2012 Feb 14;3:30. (PMID: 22347875)
RNA. 2017 Oct;23(10):1493-1501. (PMID: 28724534)
Trends Biochem Sci. 2003 Feb;28(2):69-74. (PMID: 12575993)
Nucleic Acids Res. 2003 Jul 1;31(13):3406-15. (PMID: 12824337)
Brief Bioinform. 2018 Sep 28;19(5):905-917. (PMID: 28387786)
Cell Host Microbe. 2016 May 11;19(5):675-85. (PMID: 27117054)
Bioinformatics. 2016 Oct 1;32(19):3047-8. (PMID: 27312411)
Nat Chem Biol. 2014 Feb;10(2):93-5. (PMID: 24316715)
Cell Host Microbe. 2016 Nov 9;20(5):666-673. (PMID: 27773536)
FEBS Lett. 2013 Aug 2;587(15):2405-11. (PMID: 23770094)
J Gen Virol. 1999 May;80 ( Pt 5):1305-1310. (PMID: 10355777)
Cell Res. 2014 Dec;24(12):1490-2. (PMID: 25412658)
Cell. 2014 May 8;157(4):869-81. (PMID: 24813610)
PLoS Pathog. 2015 Mar 20;11(3):e1004771. (PMID: 25794275)
Adv Virus Res. 2014;88:111-59. (PMID: 24373311)
Nat Microbiol. 2016 Feb 22;1:16011. (PMID: 27572442)
Genome Res. 2002 Jun;12(6):996-1006. (PMID: 12045153)
Nat Chem Biol. 2011 Oct 16;7(12):885-7. (PMID: 22002720)
Bioinformatics. 2013 Jan 1;29(1):15-21. (PMID: 23104886)
Cell Res. 2017 Mar;27(3):315-328. (PMID: 28106072)
Nature. 2012 Apr 29;485(7397):201-6. (PMID: 22575960)
Nat Med. 1996 Mar;2(3):342-6. (PMID: 8612236)
Nature. 2017 Mar 23;543(7646):573-576. (PMID: 28297716)
Virology. 2009 Apr 10;386(2):290-302. (PMID: 19233445)
PLoS Pathog. 2018 Feb 15;14(2):e1006919. (PMID: 29447282)
Mol Cell. 2013 Jan 10;49(1):18-29. (PMID: 23177736)
J Virol. 2003 Apr;77(7):4205-20. (PMID: 12634378)
Cell. 2012 Jun 22;149(7):1635-46. (PMID: 22608085)
Nat Biotechnol. 2011 Jan;29(1):24-6. (PMID: 21221095)
Virology. 2009 Sep 1;391(2):304-14. (PMID: 19580983)
Genome Res. 2012 Oct;22(10):2008-17. (PMID: 22722343)
Nucleic Acids Res. 2016 Jan 4;44(D1):D259-65. (PMID: 26464443)
Nat Cell Biol. 2018 Mar;20(3):285-295. (PMID: 29476152)
Adv Appl Microbiol. 2009;68:241-61. (PMID: 19426857)
J Gen Virol. 2011 Apr;92(Pt 4):796-806. (PMID: 21148275)
Nucleic Acids Res. 2008 Jun;36(11):3579-89. (PMID: 18453631)
Cell Rep. 2019 Jul 23;28(4):845-854.e5. (PMID: 31340148)
Bioinformatics. 2016 Jun 15;32(12):1840-7. (PMID: 26873928)
Bioinformatics. 2009 Aug 15;25(16):2078-9. (PMID: 19505943)
PLoS Pathog. 2014 Jan;10(1):e1003847. (PMID: 24453964)
Nature. 2015 Mar 26;519(7544):482-5. (PMID: 25799998)
Biochemistry. 2016 Mar 22;55(11):1570-83. (PMID: 26650180)
Hum Mol Genet. 2015 Mar 15;24(6):1733-40. (PMID: 25416280)
Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13834-9. (PMID: 25201973)
J Virol. 2017 Jul 27;91(16):. (PMID: 28592530)
J Virol. 2012 Sep;86(17):9454-64. (PMID: 22740398)
Nucleic Acids Res. 2007;35(13):4485-94. (PMID: 17576664)
Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18398-403. (PMID: 20937909)
Nature. 2015 Feb 26;518(7540):560-4. (PMID: 25719671)
Nature. 2014 Jan 2;505(7481):117-20. (PMID: 24284625)
Nucleic Acids Res. 2009 Jul;37(Web Server issue):W202-8. (PMID: 19458158)
Nature. 2016 Sep 15;537(7620):369-373. (PMID: 27602518)
Nat Rev Mol Cell Biol. 2011 Sep 14;12(10):629-42. (PMID: 21915143)
معلومات مُعتمدة: BB/M006557/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; MR/M009084/1 United Kingdom MRC_ Medical Research Council; MR/R010145/1 United Kingdom MRC_ Medical Research Council
فهرسة مساهمة: Keywords: RNA modification; infectious disease; m6A; microbiology; virus; virus infection
سلسلة جزيئية: GEO GSE119026; GSE63591; GSM1197605
المشرفين على المادة: 0 (RNA, Messenger)
0 (RNA, Viral)
CLE6G00625 (N-methyladenosine)
EC 3.1.- (Endonucleases)
EC 3.1.- (SND1 protein, human)
K72T3FS567 (Adenosine)
تواريخ الأحداث: Date Created: 20191025 Date Completed: 20200330 Latest Revision: 20240306
رمز التحديث: 20240306
مُعرف محوري في PubMed: PMC6812964
DOI: 10.7554/eLife.47261
PMID: 31647415
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.47261