دورية أكاديمية
أعرض في EDS

TDP-43 regulates transcription at protein-coding genes and Alu retrotransposons.

التفاصيل البيبلوغرافية
العنوان: TDP-43 regulates transcription at protein-coding genes and Alu retrotransposons.
المؤلفون: Morera AA; Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA; Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA., Ahmed NS; Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA; Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA., Schwartz JC; Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA. Electronic address: jcschwartz@email.arizona.edu.
المصدر: Biochimica et biophysica acta. Gene regulatory mechanisms [Biochim Biophys Acta Gene Regul Mech] 2019 Oct; Vol. 1862 (10), pp. 194434. Date of Electronic Publication: 2019 Oct 23.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731723 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-4320 (Electronic) Linking ISSN: 18749399 NLM ISO Abbreviation: Biochim Biophys Acta Gene Regul Mech Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier,
مواضيع طبية MeSH: Transcription, Genetic*, Alu Elements/*genetics , DNA-Binding Proteins/*genetics , Open Reading Frames/*genetics, Genome, Human/genetics ; Humans ; RNA Splicing/genetics ; RNA-Binding Proteins/genetics ; Retroelements/genetics ; Transcription Factors/genetics ; Transcriptional Activation/genetics
مستخلص: The 43-kDa transactive response DNA-binding protein (TDP-43) is an example of an RNA-binding protein that regulates RNA metabolism at multiple levels from transcription and splicing to translation. Its role in post-transcriptional RNA processing has been a primary focus of recent research, but its role in regulating transcription has been studied for only a few human genes. We characterized the effects of TDP-43 on transcription genome-wide and found that TDP-43 broadly affects transcription of protein-coding and noncoding RNA genes. Among protein-coding genes, the effects of TDP-43 were greatest for genes <30 thousand base pairs in length. Surprisingly, we found that the loss of TDP-43 resulted in increased evidence for transcription activity near repetitive Alu elements found within expressed genes. The highest densities of affected Alu elements were found in the shorter genes, whose transcription was most affected by TDP-43. Thus, in addition to its role in post-transcriptional RNA processing, TDP-43 plays a critical role in maintaining the transcriptional stability of protein-coding genes and transposable DNA elements.
(Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.)
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معلومات مُعتمدة: R00 NS082376 United States NS NINDS NIH HHS; S10 OD013237 United States OD NIH HHS; R21 CA238499 United States CA NCI NIH HHS; K22 CA184235 United States CA NCI NIH HHS; K99 NS082376 United States NS NINDS NIH HHS
فهرسة مساهمة: Keywords: Alu SINE; GRO-seq; Retrotransposon; TARDBP; TDP-43; Transcription
المشرفين على المادة: 0 (DNA-Binding Proteins)
0 (RNA-Binding Proteins)
0 (Retroelements)
0 (TARDBP protein, human)
0 (Transcription Factors)
تواريخ الأحداث: Date Created: 20191027 Date Completed: 20200130 Latest Revision: 20220716
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6899060
DOI: 10.1016/j.bbagrm.2019.194434
PMID: 31655156
قاعدة البيانات: MEDLINE
الوصف
تدمد:1876-4320
DOI:10.1016/j.bbagrm.2019.194434