دورية أكاديمية
أعرض في EDS

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Prognostic Inflammatory Biomarkers in Human Immunodeficiency Virus (HIV), Hepatitis C Virus (HCV), and HIV/HCV Coinfection.

التفاصيل البيبلوغرافية
العنوان: Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Prognostic Inflammatory Biomarkers in Human Immunodeficiency Virus (HIV), Hepatitis C Virus (HCV), and HIV/HCV Coinfection.
المؤلفون: Hanberg JS; Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.; VA Connecticut Healthcare System, West Haven., Freiberg MS; Department of Medicine and Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee., Goetz MB; Division of Infectious Diseases, University of California, David Geffen School of Medicine, Los Angeles.; Greater Los Angeles VA Healthcare Center, California., Rodriguez-Barradas MC; Department of Medicine and Infectious Disease, Baylor College of Medicine, Houston, Texas.; Michael E. DeBakey VA Medical Center, Houston, Texas., Gibert C; Division of Infectious Diseases and Medicine, George Washington University, School of Medicine and Health Sciences, Washington, District of Columbia., Oursler KA; Department of Medicine, Virginia Tech Carilion School of Medicine, Salem.; University of Maryland School of Medicine, Baltimore., Justice AC; Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.; VA Connecticut Healthcare System, West Haven., Tate JP; Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.; VA Connecticut Healthcare System, West Haven.
مؤلفون مشاركون: VACS Project Team
المصدر: Open forum infectious diseases [Open Forum Infect Dis] 2019 Jul 26; Vol. 6 (10), pp. ofz347. Date of Electronic Publication: 2019 Jul 26 (Print Publication: 2019).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Published by Oxford University Press on behalf of the Infectious Diseases Society of America Country of Publication: United States NLM ID: 101637045 Publication Model: eCollection Cited Medium: Print ISSN: 2328-8957 (Print) Linking ISSN: 23288957 NLM ISO Abbreviation: Open Forum Infect Dis Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Cary, NC : Published by Oxford University Press on behalf of the Infectious Diseases Society of America, [2014]-
مستخلص: Background: Inflammation in human immunodeficiency virus (HIV)-infected patients is associated with poorer health outcomes. Whether inflammation as measured by the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) adds information to existing prognostic indices is not known.
Methods: We analyzed data from 2000 to 2012 in the Veterans Aging Cohort Study (VACS), overall and stratified by HIV/hepatitis C virus status (n = 89 786). We randomly selected a visit date at which all laboratory values of interest were available within 180 days; participants with HIV received at least 1 year of antiretroviral therapy. We followed patients for (1) mortality and (2) hepatic decompensation (HD) and analyzed associations using Cox regression, adjusted for a validated mortality risk index (VACS Index 2.0). In VACS Biomarker Cohort, we considered correlation with biomarkers of inflammation: interleukin-6, D-dimer, and soluble CD-14.
Results: Neutrophil-to-lymphocyte ratio and PLR demonstrated strong unadjusted associations with mortality ( P < .0001) and HD ( P < .0001) and were weakly correlated with other inflammatory biomarkers. Although NLR remained statistically independent for mortality, as did PLR for HD, the addition of NLR and PLR to the VACS Index 2.0 did not result in significant improvement in discrimination compared with VACS Index 2.0 alone for mortality (C-statistic 0.767 vs 0.758) or for HD (C-statistic 0.805 vs 0.801).
Conclusions: Neutrophil-to-lymphocyte ratio and PLR were strongly associated with mortality and HD and weakly correlated with inflammatory biomarkers. However, most of their association was explained by VACS Index 2.0. Addition of NLR and PLR to VACS 2.0 did not substantially improve discrimination for either outcome.
(Published by Oxford University Press on behalf of Infectious Diseases Society of America 2019.)
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معلومات مُعتمدة: T35 HL007649 United States HL NHLBI NIH HHS; U10 AA013566 United States AA NIAAA NIH HHS; UL1 TR001863 United States TR NCATS NIH HHS
فهرسة مساهمة: Keywords: HCV; NLR; PLR; hepatic decompensation; inflammation
تواريخ الأحداث: Date Created: 20191030 Latest Revision: 20240421
رمز التحديث: 20240421
مُعرف محوري في PubMed: PMC6786514
DOI: 10.1093/ofid/ofz347
PMID: 31660334
قاعدة البيانات: MEDLINE
الوصف
تدمد:2328-8957
DOI:10.1093/ofid/ofz347