تقرير
Mycophenolate Mofetil-induced Oral Ulcerations in a Kidney Transplant Recipient.
| العنوان: | Mycophenolate Mofetil-induced Oral Ulcerations in a Kidney Transplant Recipient. |
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| المؤلفون: | Gaied H; Department of Nephrology, Mongi Slim Hospital, La Marsa, Tunisia.; Faculty of Medicine, University Tunis El Manar, Tunis, Tunisia., Bacha MM; Faculty of Medicine, University Tunis El Manar, Tunis, Tunisia.; Department of Internal Medicine A, Charles Nicolle Hospital, Tunis, Tunisia., Mesbahi T; Department of Internal Medicine A, Charles Nicolle Hospital, Tunis, Tunisia., Ounissi M; Faculty of Medicine, University Tunis El Manar, Tunis, Tunisia.; Department of Internal Medicine A, Charles Nicolle Hospital, Tunis, Tunisia., Aoudia R; Faculty of Medicine, University Tunis El Manar, Tunis, Tunisia.; Department of Internal Medicine A, Charles Nicolle Hospital, Tunis, Tunisia., Jerbi M; Department of Nephrology, Mongi Slim Hospital, La Marsa, Tunisia.; Faculty of Medicine, University Tunis El Manar, Tunis, Tunisia., Jones M; Faculty of Medicine, University Tunis El Manar, Tunis, Tunisia.; Department of Dermatology, Charles Nicolle Hospital, Tunis, Tunisia., Ksantini M; Faculty of Medicine, University Tunis El Manar, Tunis, Tunisia.; Laboratory of Histopathology, Charles Nicolle Hospital, Tunis, Tunisia., Rammeh S; Faculty of Medicine, University Tunis El Manar, Tunis, Tunisia.; Laboratory of Histopathology, Charles Nicolle Hospital, Tunis, Tunisia., Hedri H; Faculty of Medicine, University Tunis El Manar, Tunis, Tunisia.; Department of Internal Medicine A, Charles Nicolle Hospital, Tunis, Tunisia., Goucha R; Department of Nephrology, Mongi Slim Hospital, La Marsa, Tunisia.; Faculty of Medicine, University Tunis El Manar, Tunis, Tunisia., Abdallah TB; Faculty of Medicine, University Tunis El Manar, Tunis, Tunisia.; Department of Internal Medicine A, Charles Nicolle Hospital, Tunis, Tunisia. |
| المصدر: | Current drug safety [Curr Drug Saf] 2020; Vol. 15 (1), pp. 73-76. |
| نوع المنشور: | Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: Saif Zone, Sharjah, U.A.E. Country of Publication: United Arab Emirates NLM ID: 101270895 Publication Model: Print Cited Medium: Internet ISSN: 2212-3911 (Electronic) Linking ISSN: 15748863 NLM ISO Abbreviation: Curr Drug Saf Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Francisco, CA : Saif Zone, Sharjah, U.A.E. : Bentham Science Publishers, c2006- |
| مواضيع طبية MeSH: | Kidney Transplantation*, Immunosuppressive Agents/*adverse effects , Mycophenolic Acid/*adverse effects , Mycophenolic Acid/*therapeutic use , Oral Ulcer/*chemically induced, Adult ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Male ; Steroids/therapeutic use ; Tacrolimus/therapeutic use ; Transplant Recipients |
| مستخلص: | Introduction: Mycophenolate Mofetil (MMF) is an immunosuppressive drug usually used in kidney transplants to prevent rejection. It has various adverse effects such as leucopenia, anemia, diarrhea but Mouth ulcers are rarely reported. Method: We present a case report of MMF-induced mouth ulcers in an African patient. Case Report: A 41-year-old African-male patient has painful oral ulcers which developed 5 months after kidney transplantation. The immunosuppressive maintenance regimen comprised Steroids, Tacrolimus and MMF. Result: These ulcers were firstly related to a fungic or viral infection so the patient was prescribed Fluconazole and Aciclovir without any improvement. Then, Tacrolimus blood level was checked and it was in a therapeutic range. Finally, we decide to stop MMF and the ulcers healed quickly. Discussion: Oral ulcers are frequently seen complications in immunosuppressant patient but are rarely described with MMF. These ulcers can become large and very painful and degrade patient's life quality. So when infections causes are excluded, we have to keep in mind that these ulcers can be a drug adverse effect. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: Mycophenolate mofetil; anemia; drug adverse effect; fluconazole; leucopenia; tacrolimus; ulcers. |
| المشرفين على المادة: | 0 (Immunosuppressive Agents) 0 (Steroids) HU9DX48N0T (Mycophenolic Acid) WM0HAQ4WNM (Tacrolimus) |
| تواريخ الأحداث: | Date Created: 20191030 Date Completed: 20201026 Latest Revision: 20201026 |
| رمز التحديث: | 20240829 |
| DOI: | 10.2174/1574886314666191011153609 |
| PMID: | 31660841 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2212-3911 |
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| DOI: | 10.2174/1574886314666191011153609 |