دورية أكاديمية
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New insights on cytostatic drug risk assessment in aquatic environments based on measured concentrations in surface waters.

التفاصيل البيبلوغرافية
العنوان: New insights on cytostatic drug risk assessment in aquatic environments based on measured concentrations in surface waters.
المؤلفون: Gouveia TIA; LEPABE - Laboratory for Process, Environmental, Biotechnology and Energy Engineering, Faculty of Engineering, University of Porto, R. Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal., Alves A; LEPABE - Laboratory for Process, Environmental, Biotechnology and Energy Engineering, Faculty of Engineering, University of Porto, R. Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal., Santos MSF; LEPABE - Laboratory for Process, Environmental, Biotechnology and Energy Engineering, Faculty of Engineering, University of Porto, R. Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal. Electronic address: mssantos@fe.up.pt.
المصدر: Environment international [Environ Int] 2019 Dec; Vol. 133 (Pt B), pp. 105236. Date of Electronic Publication: 2019 Oct 29.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7807270 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6750 (Electronic) Linking ISSN: 01604120 NLM ISO Abbreviation: Environ Int Subsets: MEDLINE
أسماء مطبوعة: Publication: : Amsterdam : Elsevier Science
Original Publication: Oxford; Elmsford, N. Y., Pergamon Press.
مواضيع طبية MeSH: Cytostatic Agents*/analysis , Cytostatic Agents*/toxicity , Water Pollutants, Chemical*/analysis , Water Pollutants, Chemical*/toxicity, Fresh Water/*chemistry , Risk Assessment/*methods, Aquatic Organisms/drug effects ; Environmental Monitoring/methods ; Wastewater/chemistry
مستخلص: Cytostatic drugs are compounds used to treat cancer, one of the deadliest diseases worldwide with a rising yearly incidence. However, the occurrence and concentrations of a large number of cytostatics in waters and wastewaters are unknown. Thus, this study sought to analyze the concentrations of these compounds in different aquatic environments worldwide to assess the risk that these compounds pose to aquatic organisms. The top five most monitored cytostatics in aquatic environments are fluorouracil, methotrexate, tamoxifen, ifosfamide, and cyclophosphamide. Risk quotients (RQs) based on maximum reported measured concentrations revealed that mycophenolic acid and tamoxifen pose a high risk to aquatic organisms (RQ max  ≥ 1) at concentrations observed in surface waters. Moreover, methotrexate and tegafur were categorized as moderate risk compounds, and bicalutamide was found to pose a low risk. Importantly, the available analytical methodologies for the quantification of some cytostatics (e.g., cisplatin, fluorouracil, daunorubicin, imatinib, and mycophenolic acid) in water could not rule out potential risk to aquatic biota, since estimated risks for these compounds using the lowest method detection limits reported in the literature (RQ MDL) were all ≥0.01 (i.e., low risk or higher). Moreover, risks based on predicted concentrations (RQ PEC) were consistently lower than those based on measured concentrations, highlighting the importance of risk assessment based on measured values. Thus, accurate and sensitive analytical methods are crucial to identify and quantify cytostatic exposure in aquatic ecosystems in order to preserve biodiversity and ensure a safer environment.
(Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)
فهرسة مساهمة: Keywords: Aquatic environment; Cancer; Cytostatics; Measured environmental concentrations; Risk assessment
المشرفين على المادة: 0 (Cytostatic Agents)
0 (Waste Water)
0 (Water Pollutants, Chemical)
تواريخ الأحداث: Date Created: 20191102 Date Completed: 20200226 Latest Revision: 20221207
رمز التحديث: 20240628
DOI: 10.1016/j.envint.2019.105236
PMID: 31675568
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-6750
DOI:10.1016/j.envint.2019.105236