دورية أكاديمية
أعرض في EDS

Effects of levothyroxine therapy on bone mineral density and bone turnover markers in premenopausal women with thyroid cancer after thyroidectomy.

التفاصيل البيبلوغرافية
العنوان: Effects of levothyroxine therapy on bone mineral density and bone turnover markers in premenopausal women with thyroid cancer after thyroidectomy.
المؤلفون: Bin-Hong D; Department of endocrinology, Heilongjiang Provincial Hospital, Harbin Heilongjiang Province, China., Fu-Man D; Department of endocrinology, Heilongjiang Provincial Hospital, Harbin Heilongjiang Province, China. physiciandu@outlook.com., Yu L; Department of endocrinology, Heilongjiang Provincial Hospital, Harbin Heilongjiang Province, China., Xu-Ping W; Department of endocrinology, Heilongjiang Provincial Hospital, Harbin Heilongjiang Province, China., Bing-Feng B; Department of endocrinology, Heilongjiang Provincial Hospital, Harbin Heilongjiang Province, China.
المصدر: Endokrynologia Polska [Endokrynol Pol] 2020; Vol. 71 (1), pp. 15-20. Date of Electronic Publication: 2019 Nov 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Via Medica Country of Publication: Poland NLM ID: 0370674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2299-8306 (Electronic) Linking ISSN: 0423104X NLM ISO Abbreviation: Endokrynol Pol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005- > : Gdańsk : Via Medica
Original Publication: Warszawa : Wydawnictwo Viamedica SPZOO
مواضيع طبية MeSH: Bone Density/*drug effects , Bone Remodeling/*drug effects , Premenopause/*metabolism , Thyroxine/*adverse effects, Adult ; Case-Control Studies ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Thyroid Neoplasms/surgery ; Time Factors
مستخلص: Introduction: We investigated the impact of long-term levothyroxine (LT4) treatment on bone mineral density (BMD) and bone turnover markers (BTMs) in premenopausal women with differentiated thyroid cancer (DTC) after thyroidectomy.
Material and Methods: Sixty-five premenopausal women who received LT4 therapy at least one year (range, 1.5-9.0 years) after thyroidectomy for DTC and 50 premenopausal women without thyroid diseases were enrolled in this study. We measured the Z-scores of lumbar and hip BMD, serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), intact parathyroid hormone (iPTH), N-terminal propeptide of type 1 N procollagen (P1NP), C terminal telopeptide of type 1 collagen (CTX-1), calcium (Ca), phosphorus (P), vitamin D3, and alkaline phosphatase (ALP) in all participants.
Results: In DTC subjects, serum TSH levels were lower, and serum FT4, P1NP, CTX-1, and ALP levels were higher compared with controls. The prevalence of low BMD was higher in DTC subjects than in controls. Multivariate logistic regression analysis showed that serum TSH levels were negatively associated with CTX-1 and ALP.
Conclusions: We found a high prevalence of low BMD among premenopausal women who received long-term LT4 therapy for DTC after thyroidectomy. Long-term TSH suppression therapy was a significant risk factor for decreased bone strength, mainly by increasing bone turnover.
فهرسة مساهمة: Keywords: bone mineral density; bone turnover markers; levothyroxine; thyroid cancer; thyroidectomy; women
المشرفين على المادة: Q51BO43MG4 (Thyroxine)
تواريخ الأحداث: Date Created: 20191105 Date Completed: 20201130 Latest Revision: 20201130
رمز التحديث: 20231215
DOI: 10.5603/EP.a2019.0049
PMID: 31681976
قاعدة البيانات: MEDLINE
الوصف
تدمد:2299-8306
DOI:10.5603/EP.a2019.0049