دورية أكاديمية
أعرض في EDS

LDL aggregation susceptibility is higher in healthy South Asian compared with white Caucasian men.

التفاصيل البيبلوغرافية
العنوان: LDL aggregation susceptibility is higher in healthy South Asian compared with white Caucasian men.
المؤلفون: Ruuth M; Atherosclerosis Research Laboratory, Wihuri Research Institute, Helsinki, Finland; Research Program Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Janssen LGM; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands., Äikäs L; Atherosclerosis Research Laboratory, Wihuri Research Institute, Helsinki, Finland; Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland., Tigistu-Sahle F; Atherosclerosis Research Laboratory, Wihuri Research Institute, Helsinki, Finland; Health Biotechnology Directorate, Ethiopian Biotechnology Institute, Addis Ababa, Ethiopia., Nahon KJ; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands., Ritvos O; Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Ruhanen H; Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland; Helsinki University Lipidomics Unit (HiLIPID), Helsinki Institute for Life Sciences (HiLIFE), University of Helsinki, Helsinki, Finland., Käkelä R; Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland; Helsinki University Lipidomics Unit (HiLIPID), Helsinki Institute for Life Sciences (HiLIFE), University of Helsinki, Helsinki, Finland., Boon MR; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands., Öörni K; Atherosclerosis Research Laboratory, Wihuri Research Institute, Helsinki, Finland; Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland. Electronic address: kati.oorni@wri.fi., Rensen PCN; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.
المصدر: Journal of clinical lipidology [J Clin Lipidol] 2019 Nov - Dec; Vol. 13 (6), pp. 910-919.e2. Date of Electronic Publication: 2019 Sep 30.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101300157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-2874 (Print) Linking ISSN: 18764789 NLM ISO Abbreviation: J Clin Lipidol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Elsevier
مواضيع طبية MeSH: Arteriosclerosis/*blood , Lipoproteins, LDL/*blood , Lipoproteins, LDL/*metabolism , Triglycerides/*blood, Adolescent ; Adult ; Animals ; Arteriosclerosis/metabolism ; Asian People ; CHO Cells ; Cricetulus ; Cross-Sectional Studies ; Humans ; Male ; Mass Spectrometry ; Sphingomyelin Phosphodiesterase/therapeutic use ; Triglycerides/metabolism ; White People ; Young Adult
مستخلص: Background: South Asians are more prone to develop atherosclerotic cardiovascular disease (ASCVD) compared with white Caucasians, which is not fully explained by classical risk factors. We recently reported that the presence of aggregation-prone low-density lipoprotein (LDL) in the circulation is associated with increased ASCVD mortality.
Objective: We hypothesized that LDL of South Asians is more prone to aggregate, which may be explained by differences in their LDL lipid composition.
Methods: In this cross-sectional hypothesis-generating study, LDL was isolated from plasma of healthy South Asians (n = 12) and age- and BMI-matched white Caucasians (n = 12), and its aggregation susceptibility and lipid composition were analyzed.
Results: LDL from South Asians was markedly more prone to aggregate compared with white Caucasians. Among all measured lipids, sphingomyelin 24:0 and triacylglycerol 56:8 showed the highest positive correlation with LDL aggregation. In addition, LDL from South Asians was enriched in arachidonic acid containing phosphatidylcholine 38:4 and had less phosphatidylcholines and cholesteryl esters containing monounsaturated fatty acids. Interestingly, body fat percentage, which was higher in South Asians (+26%), positively correlated with LDL aggregation and highly positively correlated with triacylglycerol 56:8, sphingomyelin 24:0, and total sphingomyelin.
Conclusions: LDL aggregation susceptibility is higher in healthy young South Asians compared with white Caucasians. This may be partly explained by the higher body fat percentage of South Asians, leading to sphingomyelin enrichment of LDL. We anticipate that the presence of sphingomyelin-rich, aggregation-prone LDL particles in young South Asians may increase LDL accumulation in the arterial wall and thereby contribute to their increased risk of developing ASCVD later in life.
(Copyright © 2019 National Lipid Association. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Atherosclerosis; Ethnicity; LDL; LDL aggregation; Lipidomics; South Asians; Sphingomyelin
المشرفين على المادة: 0 (Lipoproteins, LDL)
0 (Triglycerides)
EC 3.1.4.12 (Sphingomyelin Phosphodiesterase)
تواريخ الأحداث: Date Created: 20191123 Date Completed: 20200720 Latest Revision: 20221207
رمز التحديث: 20231215
DOI: 10.1016/j.jacl.2019.09.011
PMID: 31753722
قاعدة البيانات: MEDLINE
الوصف
تدمد:1933-2874
DOI:10.1016/j.jacl.2019.09.011