دورية أكاديمية
New insights into human beta cell biology using human pluripotent stem cells.
| العنوان: | New insights into human beta cell biology using human pluripotent stem cells. |
|---|---|
| المؤلفون: | Amirruddin NS; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), A*STAR, Proteos, Singapore, 138673, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Low BSJ; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), A*STAR, Proteos, Singapore, 138673, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Lee KO; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Tai ES; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore. Electronic address: mdctes@nus.edu.sg., Teo AKK; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), A*STAR, Proteos, Singapore, 138673, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore. Electronic address: ateo@imcb.a-star.edu.sg. |
| المصدر: | Seminars in cell & developmental biology [Semin Cell Dev Biol] 2020 Jul; Vol. 103, pp. 31-40. Date of Electronic Publication: 2019 Nov 19. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: England NLM ID: 9607332 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-3634 (Electronic) Linking ISSN: 10849521 NLM ISO Abbreviation: Semin Cell Dev Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Academic Press Original Publication: London, UK : Academic Press, c1996- |
| مواضيع طبية MeSH: | Cell Biology/*standards , Diabetes Mellitus/*metabolism , Induced Pluripotent Stem Cells/*metabolism, Cell Differentiation ; Humans |
| مستخلص: | Pancreatic β-cells are responsible for maintaining glucose homeostasis. Therefore, their dysregulation leads to diabetes. Pancreas or islet transplants can be used to treat diabetes but these human tissues remain in short supply. Significant progress has now been made in differentiating human pluripotent stem cells (hPSCs) such as human embryonic stem cells (hESCs) or human induced pluripotent stem cells (hiPSCs) into pancreatic β-like cells for potential cell replacement therapy. Additionally, these hPSC-derived β-like cells represent a new invaluable model for studying diabetes disease mechanisms. Here, we review the use of hPSC-derived β-like cells as a platform to model various types of defects in human β-cells in diabetes, comparing them against existing animal models, ex vivo human islets and human β-cell line. We also discuss how hPSC-derived β-like cells are being used as a platform for screening novel therapeutic compounds. Last but not least, we evaluate the strengths and limitations of this human cell-based platform as an avenue to study and reveal new insights into human β-cell biology. (Copyright © 2019 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Beta cell; Diabetes; Disease modelling; Human; Pancreas; Pluripotent stem cell; iPS |
| تواريخ الأحداث: | Date Created: 20191124 Date Completed: 20210624 Latest Revision: 20210624 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.semcdb.2019.11.004 |
| PMID: | 31757584 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-3634 |
|---|---|
| DOI: | 10.1016/j.semcdb.2019.11.004 |